ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 15/166 80/7206 2.62564794804e-10 ko04911 Insulin secretion 17/166 117/7206 1.04083800649e-09 ko04727 GABAergic synapse 16/166 110/7206 3.26497571257e-09 ko04725 Cholinergic synapse 18/166 160/7206 2.153043367e-08 ko04724 Glutamatergic synapse 17/166 152/7206 5.94054926175e-08 ko05032 Morphine addiction 14/166 110/7206 1.84796880645e-07 ko04728 Dopaminergic synapse 18/166 185/7206 2.05180587029e-07 ko04713 Circadian entrainment 15/166 136/7206 4.47284594548e-07 ko04966 Collecting duct acid secretion 7/166 26/7206 1.37988952594e-06 ko04080 Neuroactive ligand-receptor interaction 26/166 423/7206 3.5288893743e-06 ko05110 Vibrio cholerae infection 9/166 63/7206 1.19759863718e-05 ko04723 Retrograde endocannabinoid signaling 14/166 175/7206 4.66401084687e-05 ko04726 Serotonergic synapse 12/166 137/7206 6.88913605854e-05 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/166 92/7206 0.000248361538825 ko05033 Nicotine addiction 7/166 56/7206 0.000272053126671 ko04961 Endocrine and other factor-regulated calcium reabsorption 7/166 59/7206 0.000377680445848 ko04964 Proximal tubule bicarbonate reclamation 5/166 29/7206 0.000463335434944 ko04925 Aldosterone synthesis and secretion 9/166 105/7206 0.000665598879479 ko04924 Renin secretion 8/166 86/7206 0.000772279364674 ko04261 Adrenergic signaling in cardiomyocytes 13/166 205/7206 0.000855717999053 ko05323 Rheumatoid arthritis 8/166 89/7206 0.000969678994537 ko05031 Amphetamine addiction 8/166 91/7206 0.00112237557088 ko04145 Phagosome 11/166 162/7206 0.00123428981195 ko04971 Gastric acid secretion 8/166 98/7206 0.0018141412233 ko04024 cAMP signaling pathway 15/166 279/7206 0.00186998086187 ko04072 Phospholipase D signaling pathway 12/166 197/7206 0.00190538397256 ko04371 Apelin signaling pathway 11/166 177/7206 0.00250445613576 ko00190 Oxidative phosphorylation 9/166 127/7206 0.00255194649074 ko04921 Oxytocin signaling pathway 12/166 209/7206 0.00311528057717 ko04972 Pancreatic secretion 8/166 111/7206 0.00395683552327 ko04020 Calcium signaling pathway 14/166 265/7206 0.00495087648979 ko04940 Type I diabetes mellitus 4/166 32/7206 0.00590543604376 ko04970 Salivary secretion 7/166 95/7206 0.00613084472538 ko04014 Ras signaling pathway 14/166 279/7206 0.0062300236453 ko04720 Long-term potentiation 7/166 99/7206 0.00765300356598 ko04976 Bile secretion 6/166 80/7206 0.0100678413778 ko04745 Phototransduction - fly 4/166 38/7206 0.0108962885152 ko04070 Phosphatidylinositol signaling system 7/166 112/7206 0.0145446503653 ko04022 cGMP-PKG signaling pathway 11/166 216/7206 0.0170305480808 ko04750 Inflammatory mediator regulation of TRP channels 7/166 122/7206 0.0222526671034 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/166 1/7206 0.02303635859 ko05030 Cocaine addiction 5/166 73/7206 0.02609291695 ko04062 Chemokine signaling pathway 10/166 201/7206 0.0261060927973 ko05014 Amyotrophic lateral sclerosis (ALS) 5/166 74/7206 0.0274803863448 ko04540 Gap junction 7/166 128/7206 0.0280391579256 ko04015 Rap1 signaling pathway 12/166 278/7206 0.0370974355089 ko00430 Taurine and hypotaurine metabolism 2/166 14/7206 0.0400331447291 ko05167 Kaposi's sarcoma-associated herpesvirus infection 9/166 191/7206 0.0430046847897 ko02024 Quorum sensing 2/166 15/7206 0.0455066881879 ko04918 Thyroid hormone synthesis 5/166 86/7206 0.0478271001343