ko pathway ratio_in_study ratio_in_pop p_value ko04911 Insulin secretion 24/260 117/7206 2.28716218947e-12 ko04721 Synaptic vesicle cycle 19/260 80/7206 3.24536065357e-11 ko04724 Glutamatergic synapse 24/260 152/7206 7.3130305233e-10 ko04713 Circadian entrainment 22/260 136/7206 2.42171587231e-09 ko04966 Collecting duct acid secretion 10/260 26/7206 1.00437523241e-08 ko04725 Cholinergic synapse 23/260 160/7206 1.08988651297e-08 ko04080 Neuroactive ligand-receptor interaction 40/260 423/7206 1.27945467907e-08 ko05110 Vibrio cholerae infection 14/260 63/7206 3.43106552021e-08 ko04728 Dopaminergic synapse 24/260 185/7206 4.01166973909e-08 ko05031 Amphetamine addiction 16/260 91/7206 1.19500978189e-07 ko04024 cAMP signaling pathway 29/260 279/7206 2.14198637145e-07 ko04720 Long-term potentiation 16/260 99/7206 4.00078367532e-07 ko04727 GABAergic synapse 16/260 110/7206 1.72895669268e-06 ko04261 Adrenergic signaling in cardiomyocytes 22/260 205/7206 4.02140473157e-06 ko05120 Epithelial cell signaling in Helicobacter pylori infection 14/260 92/7206 4.52305644942e-06 ko04971 Gastric acid secretion 14/260 98/7206 9.64782697303e-06 ko04925 Aldosterone synthesis and secretion 14/260 105/7206 2.16388479558e-05 ko04020 Calcium signaling pathway 24/260 265/7206 2.70353224649e-05 ko04726 Serotonergic synapse 16/260 137/7206 3.05468090634e-05 ko05032 Morphine addiction 14/260 110/7206 3.68683902606e-05 ko04921 Oxytocin signaling pathway 20/260 209/7206 5.98533099202e-05 ko04114 Oocyte meiosis 15/260 139/7206 0.000134816859295 ko04723 Retrograde endocannabinoid signaling 17/260 175/7206 0.000179605062814 ko05014 Amyotrophic lateral sclerosis (ALS) 10/260 74/7206 0.000294303680263 ko05323 Rheumatoid arthritis 11/260 89/7206 0.000328397154667 ko04626 Plant-pathogen interaction 5/260 18/7206 0.000342575993014 ko04745 Phototransduction - fly 7/260 38/7206 0.000354852715196 ko04970 Salivary secretion 11/260 95/7206 0.000580066867181 ko04145 Phagosome 15/260 162/7206 0.000715647214366 ko05033 Nicotine addiction 8/260 56/7206 0.000814794922917 ko04022 cGMP-PKG signaling pathway 18/260 216/7206 0.00108286843084 ko04961 Endocrine and other factor-regulated calcium reabsorption 8/260 59/7206 0.00115869541648 ko05030 Cocaine addiction 9/260 73/7206 0.00116001171978 ko04912 GnRH signaling pathway 12/260 122/7206 0.00143471533093 ko04360 Axon guidance 18/260 233/7206 0.00199264694094 ko00190 Oxidative phosphorylation 12/260 127/7206 0.00202656713666 ko04972 Pancreatic secretion 11/260 111/7206 0.00211519967272 ko04922 Glucagon signaling pathway 12/260 128/7206 0.00216612304024 ko04540 Gap junction 12/260 128/7206 0.00216612304024 ko04514 Cell adhesion molecules (CAMs) 12/260 130/7206 0.00246886692543 ko04014 Ras signaling pathway 20/260 279/7206 0.00287459598897 ko04964 Proximal tubule bicarbonate reclamation 5/260 29/7206 0.00343186557056 ko04924 Renin secretion 9/260 86/7206 0.00365909988787 ko04918 Thyroid hormone synthesis 9/260 86/7206 0.00365909988787 ko04750 Inflammatory mediator regulation of TRP channels 11/260 122/7206 0.00442828494051 ko04916 Melanogenesis 12/260 142/7206 0.00509043801792 ko00680 Methane metabolism 5/260 34/7206 0.00694538105989 ko04070 Phosphatidylinositol signaling system 10/260 112/7206 0.0069987830094 ko04015 Rap1 signaling pathway 19/260 278/7206 0.00751193292118 ko04976 Bile secretion 8/260 80/7206 0.00791311655199 ko04740 Olfactory transduction 8/260 80/7206 0.00791311655199 ko04371 Apelin signaling pathway 13/260 177/7206 0.012841584156 ko00010 Glycolysis / Gluconeogenesis 7/260 74/7206 0.0168654345253 ko04062 Chemokine signaling pathway 14/260 201/7206 0.0185920670812 ko05034 Alcoholism 16/260 238/7206 0.0191816160277 ko04730 Long-term depression 7/260 78/7206 0.0219464780728 ko04742 Taste transduction 6/260 61/7206 0.0220104227461 ko04260 Cardiac muscle contraction 8/260 98/7206 0.0247562166582 ko00030 Pentose phosphate pathway 4/260 32/7206 0.0269204347693 ko04915 Estrogen signaling pathway 10/260 131/7206 0.0274681087854 ko04072 Phospholipase D signaling pathway 13/260 197/7206 0.0312079443732 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/260 1/7206 0.0360810435749 ko04310 Wnt signaling pathway 12/260 181/7206 0.0398003055643 ko04066 HIF-1 signaling pathway 9/260 123/7206 0.0437773609523 ko05322 Systemic lupus erythematosus 1/260 151/7206 0.0451906937625 ko05152 Tuberculosis 12/260 187/7206 0.0454137046425 ko04621 NOD-like receptor signaling pathway 1/260 157/7206 0.0467886888684 ko04722 Neurotrophin signaling pathway 11/260 160/7206 0.0482989269538