ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 59/522 191/7206 4.31584893654e-23 ko04380 Osteoclast differentiation 44/522 134/7206 1.3785634121e-18 ko04621 NOD-like receptor signaling pathway 45/522 157/7206 2.04294189816e-16 ko05164 Influenza A 42/522 167/7206 3.1144615814e-13 ko04064 NF-kappa B signaling pathway 31/522 96/7206 3.29336213948e-13 ko05140 Leishmaniasis 26/522 75/7206 4.39612490164e-12 ko05145 Toxoplasmosis 34/522 126/7206 7.32768783591e-12 ko05340 Primary immunodeficiency 16/522 30/7206 2.58413441477e-11 ko05162 Measles 32/522 120/7206 4.35235844781e-11 ko05321 Inflammatory bowel disease (IBD) 21/522 56/7206 9.50440782565e-11 ko04650 Natural killer cell mediated cytotoxicity 28/522 97/7206 9.64666556561e-11 ko05168 Herpes simplex infection 40/522 182/7206 1.11295087654e-10 ko04659 Th17 cell differentiation 29/522 106/7206 1.8569634914e-10 ko04217 Necroptosis 39/522 178/7206 2.12060475868e-10 ko05150 Staphylococcus aureus infection 16/522 36/7206 8.61581884538e-10 ko04620 Toll-like receptor signaling pathway 27/522 100/7206 1.1024652883e-09 ko05330 Allograft rejection 13/522 24/7206 1.55580840398e-09 ko05152 Tuberculosis 38/522 187/7206 3.53705484097e-09 ko04660 T cell receptor signaling pathway 29/522 124/7206 9.91644694032e-09 ko04658 Th1 and Th2 cell differentiation 25/522 96/7206 1.03627241614e-08 ko04672 Intestinal immune network for IgA production 15/522 37/7206 1.37103932033e-08 ko05320 Autoimmune thyroid disease 13/522 29/7206 3.01464511416e-08 ko05332 Graft-versus-host disease 10/522 18/7206 9.41728850776e-08 ko04612 Antigen processing and presentation 20/522 77/7206 3.28976282784e-07 ko04640 Hematopoietic cell lineage 18/522 64/7206 3.51743999536e-07 ko04610 Complement and coagulation cascades 20/522 79/7206 5.16458455202e-07 ko04630 Jak-STAT signaling pathway 27/522 132/7206 6.01862440656e-07 ko05133 Pertussis 21/522 87/7206 6.35239022189e-07 ko05167 Kaposi's sarcoma-associated herpesvirus infection 34/522 191/7206 6.87702937819e-07 ko05323 Rheumatoid arthritis 21/522 89/7206 9.51943270766e-07 ko04622 RIG-I-like receptor signaling pathway 17/522 62/7206 1.10754343168e-06 ko05142 Chagas disease (American trypanosomiasis) 26/522 130/7206 1.53000651186e-06 ko05144 Malaria 14/522 45/7206 1.88811900355e-06 ko04210 Apoptosis 31/522 180/7206 5.52895141671e-06 ko05310 Asthma 8/522 17/7206 9.73514430184e-06 ko04668 TNF signaling pathway 23/522 120/7206 1.29199919595e-05 ko05161 Hepatitis B 29/522 173/7206 1.73504892376e-05 ko04623 Cytosolic DNA-sensing pathway 12/522 41/7206 2.07762597233e-05 ko00120 Primary bile acid biosynthesis 8/522 20/7206 4.15013015904e-05 ko04662 B cell receptor signaling pathway 18/522 88/7206 4.588681081e-05 ko04940 Type I diabetes mellitus 10/522 32/7206 5.48222086686e-05 ko03013 RNA transport 1/522 166/7206 9.90603273003e-05 ko04062 Chemokine signaling pathway 30/522 201/7206 0.000138121908791 ko05034 Alcoholism 4/522 238/7206 0.000176557645643 ko04611 Platelet activation 25/522 163/7206 0.000314579452998 ko05160 Hepatitis C 24/522 153/7206 0.000357588821817 ko03040 Spliceosome 1/522 145/7206 0.000478987939033 ko05418 Fluid shear stress and atherosclerosis 25/522 173/7206 0.000854949135779 ko04310 Wnt signaling pathway 3/522 181/7206 0.00119099918879 ko04657 IL-17 signaling pathway 15/522 87/7206 0.00130690439729 ko03010 Ribosome 1/522 129/7206 0.0015363409018 ko05143 African trypanosomiasis 8/522 32/7206 0.00159584437128 ko05132 Salmonella infection 16/522 98/7206 0.00225904743464 ko05134 Legionellosis 13/522 74/7206 0.00226558186821 ko05146 Amoebiasis 16/522 99/7206 0.00240636503541 ko05166 HTLV-I infection 35/522 292/7206 0.0026131319357 ko04916 Melanogenesis 2/522 142/7206 0.0028373876519 ko04728 Dopaminergic synapse 4/522 185/7206 0.00367608123878 ko04390 Hippo signaling pathway 4/522 188/7206 0.00380420506134 ko04727 GABAergic synapse 1/522 110/7206 0.00455460135657 ko05032 Morphine addiction 1/522 110/7206 0.00455460135657 ko04145 Phagosome 22/522 162/7206 0.00499349519057 ko04723 Retrograde endocannabinoid signaling 4/522 175/7206 0.00713018876295 ko05131 Shigellosis 13/522 82/7206 0.00770460270132 ko04137 Mitophagy - animal 13/522 82/7206 0.00770460270132 ko01200 Carbon metabolism 2/522 128/7206 0.0085628615562 ko05169 Epstein-Barr virus infection 25/522 206/7206 0.00925377538525 ko04360 Axon guidance 7/522 233/7206 0.00944906013922 ko00592 alpha-Linolenic acid metabolism 5/522 19/7206 0.00970641174535 ko04933 AGE-RAGE signaling pathway in diabetic complications 18/522 135/7206 0.0107735423756 ko00590 Arachidonic acid metabolism 9/522 52/7206 0.011421810822 ko03015 mRNA surveillance pathway 1/522 93/7206 0.0140182755656 ko03050 Proteasome 9/522 54/7206 0.014524519841 ko04666 Fc gamma R-mediated phagocytosis 16/522 122/7206 0.0199424221968 ko04068 FoxO signaling pathway 20/522 167/7206 0.0228162667221 ko04664 Fc epsilon RI signaling pathway 11/522 77/7206 0.025012502244 ko00140 Steroid hormone biosynthesis 7/522 41/7206 0.0262159521468 ko00051 Fructose and mannose metabolism 7/522 42/7206 0.0295686422792 ko04110 Cell cycle 4/522 145/7206 0.0338249562618 ko00010 Glycolysis / Gluconeogenesis 1/522 74/7206 0.0422126980345 ko04114 Oocyte meiosis 4/522 139/7206 0.045674484844 ko04911 Insulin secretion 3/522 117/7206 0.0468418913508 ko00982 Drug metabolism - cytochrome P450 6/522 37/7206 0.0478517886844