ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 9/122 56/7206 3.29634302746e-07 ko04721 Synaptic vesicle cycle 10/122 80/7206 8.09434494309e-07 ko04514 Cell adhesion molecules (CAMs) 11/122 130/7206 1.10517386232e-05 ko04723 Retrograde endocannabinoid signaling 12/122 175/7206 3.67214266616e-05 ko04080 Neuroactive ligand-receptor interaction 17/122 423/7206 0.000716520713424 ko04724 Glutamatergic synapse 9/122 152/7206 0.00104594486677 ko04728 Dopaminergic synapse 10/122 185/7206 0.00111523935433 ko04725 Cholinergic synapse 9/122 160/7206 0.0015005777133 ko04713 Circadian entrainment 8/122 136/7206 0.00207316621035 ko05032 Morphine addiction 7/122 110/7206 0.00252897403224 ko04970 Salivary secretion 6/122 95/7206 0.00530884690302 ko04024 cAMP signaling pathway 11/122 279/7206 0.00745423743001 ko04921 Oxytocin signaling pathway 9/122 209/7206 0.00879874003931 ko04730 Long-term depression 5/122 78/7206 0.0101156204657 ko04727 GABAergic synapse 6/122 110/7206 0.0106669674317 ko04972 Pancreatic secretion 6/122 111/7206 0.0111243936996 ko04010 MAPK signaling pathway 12/122 321/7206 0.0115950937546 ko04911 Insulin secretion 6/122 117/7206 0.0141647931893 ko04962 Vasopressin-regulated water reabsorption 4/122 58/7206 0.0164272092128 ko04961 Endocrine and other factor-regulated calcium reabsorption 4/122 59/7206 0.0173970431171 ko04742 Taste transduction 4/122 61/7206 0.0194423045034 ko05110 Vibrio cholerae infection 4/122 63/7206 0.0216305089545 ko00604 Glycosphingolipid biosynthesis - ganglio series 2/122 14/7206 0.0226507893829 ko04261 Adrenergic signaling in cardiomyocytes 8/122 205/7206 0.0226790116811 ko04915 Estrogen signaling pathway 6/122 131/7206 0.0234214156183 ko04022 cGMP-PKG signaling pathway 8/122 216/7206 0.0297975420121 ko00513 Various types of N-glycan biosynthesis 3/122 42/7206 0.033671064304 ko04923 Regulation of lipolysis in adipocytes 4/122 77/7206 0.0411036895047 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 4/122 79/7206 0.0444919139005 ko05160 Hepatitis C 6/122 153/7206 0.0449763862431