ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	189/1051	423/7206	4.39695691309e-54
ko04724	Glutamatergic synapse	89/1051	152/7206	6.61618995083e-37
ko05033	Nicotine addiction	48/1051	56/7206	1.26407455721e-32
ko05032	Morphine addiction	68/1051	110/7206	2.05888688093e-30
ko04727	GABAergic synapse	66/1051	110/7206	1.92806755922e-28
ko04713	Circadian entrainment	73/1051	136/7206	4.34441953206e-27
ko04728	Dopaminergic synapse	85/1051	185/7206	3.44049582381e-25
ko04725	Cholinergic synapse	75/1051	160/7206	5.40250756254e-23
ko04721	Synaptic vesicle cycle	49/1051	80/7206	5.96367592417e-22
ko04723	Retrograde endocannabinoid signaling	76/1051	175/7206	9.08733659359e-21
ko04024	cAMP signaling pathway	101/1051	279/7206	4.02736710915e-20
ko04911	Insulin secretion	58/1051	117/7206	1.67361149588e-19
ko04020	Calcium signaling pathway	90/1051	265/7206	8.99276218314e-16
ko04742	Taste transduction	36/1051	61/7206	1.0245678081e-15
ko04726	Serotonergic synapse	57/1051	137/7206	7.63026403454e-15
ko04921	Oxytocin signaling pathway	75/1051	209/7206	9.01165249445e-15
ko05031	Amphetamine addiction	42/1051	91/7206	4.18977029037e-13
ko04261	Adrenergic signaling in cardiomyocytes	70/1051	205/7206	1.04730337498e-12
ko04744	Phototransduction	24/1051	36/7206	1.45916011105e-12
ko04720	Long-term potentiation	43/1051	99/7206	2.87555982056e-12
ko04971	Gastric acid secretion	39/1051	98/7206	7.11953067036e-10
ko04970	Salivary secretion	38/1051	95/7206	9.90884718111e-10
ko05030	Cocaine addiction	32/1051	73/7206	1.37022267136e-09
ko04925	Aldosterone synthesis and secretion	40/1051	105/7206	1.99309045736e-09
ko03040	Spliceosome	1/1051	145/7206	3.56836183378e-09
ko04010	MAPK signaling pathway	85/1051	321/7206	1.43815693686e-08
ko05203	Viral carcinogenesis	13/1051	277/7206	1.27659460923e-07
ko04060	Cytokine-cytokine receptor interaction	6/1051	191/7206	2.08505184509e-07
ko04972	Pancreatic secretion	37/1051	111/7206	4.71371449047e-07
ko05168	Herpes simplex infection	6/1051	182/7206	6.36761887933e-07
ko04360	Axon guidance	62/1051	233/7206	1.06572783109e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1051	74/7206	2.28120647528e-06
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1051	59/7206	3.47268083904e-06
ko04740	Olfactory transduction	28/1051	80/7206	3.83891742111e-06
ko04022	cGMP-PKG signaling pathway	57/1051	216/7206	4.83398843306e-06
ko04070	Phosphatidylinositol signaling system	35/1051	112/7206	5.29897378998e-06
ko05322	Systemic lupus erythematosus	5/1051	151/7206	6.84075109976e-06
ko04141	Protein processing in endoplasmic reticulum	8/1051	184/7206	1.06383435631e-05
ko04072	Phospholipase D signaling pathway	52/1051	197/7206	1.26951662825e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1051	79/7206	1.311501578e-05
ko04730	Long-term depression	26/1051	78/7206	2.71730061203e-05
ko03013	RNA transport	7/1051	166/7206	2.83734725883e-05
ko04260	Cardiac muscle contraction	30/1051	98/7206	3.90966861055e-05
ko05414	Dilated cardiomyopathy	33/1051	112/7206	3.93804823063e-05
ko04540	Gap junction	36/1051	128/7206	6.48602882907e-05
ko04915	Estrogen signaling pathway	36/1051	131/7206	0.000134632674567
ko04621	NOD-like receptor signaling pathway	8/1051	157/7206	0.000218238768993
ko04514	Cell adhesion molecules (CAMs)	35/1051	130/7206	0.000219321179619
ko05164	Influenza A	9/1051	167/7206	0.000221761752656
ko00240	Pyrimidine metabolism	4/1051	110/7206	0.00031925253041
ko04750	Inflammatory mediator regulation of TRP channels	33/1051	122/7206	0.000379870069918
ko05110	Vibrio cholerae infection	20/1051	63/7206	0.000459455670357
ko04966	Collecting duct acid secretion	11/1051	26/7206	0.000565940916471
ko04745	Phototransduction - fly	14/1051	38/7206	0.000567214542686
ko05169	Epstein-Barr virus infection	14/1051	206/7206	0.000623806261228
ko03008	Ribosome biogenesis in eukaryotes	2/1051	79/7206	0.00062839716879
ko04110	Cell cycle	8/1051	145/7206	0.000791409404843
ko04612	Antigen processing and presentation	2/1051	77/7206	0.000931511565444
ko04924	Renin secretion	24/1051	86/7206	0.00110260759829
ko04976	Bile secretion	23/1051	80/7206	0.00110890758132
ko04932	Non-alcoholic fatty liver disease (NAFLD)	12/1051	182/7206	0.0012808289226
ko04014	Ras signaling pathway	60/1051	279/7206	0.00133739153213
ko05205	Proteoglycans in cancer	22/1051	271/7206	0.0014968056557
ko04912	GnRH signaling pathway	31/1051	122/7206	0.00164751515335
ko03018	RNA degradation	3/1051	84/7206	0.0016591378102
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1051	14/7206	0.00184491386478
ko04015	Rap1 signaling pathway	59/1051	278/7206	0.00231170775938
ko04918	Thyroid hormone synthesis	23/1051	86/7206	0.00301471757766
ko04923	Regulation of lipolysis in adipocytes	21/1051	77/7206	0.00314760430157
ko00480	Glutathione metabolism	1/1051	55/7206	0.00326568133413
ko04371	Apelin signaling pathway	40/1051	177/7206	0.00348864213711
ko04146	Peroxisome	4/1051	89/7206	0.00373904215221
ko04062	Chemokine signaling pathway	44/1051	201/7206	0.00439938867897
ko05140	Leishmaniasis	3/1051	75/7206	0.00490073960337
ko04916	Melanogenesis	33/1051	142/7206	0.00539076376813
ko04064	NF-kappa B signaling pathway	5/1051	96/7206	0.00540447952968
ko04964	Proximal tubule bicarbonate reclamation	10/1051	29/7206	0.00597023804825
ko04640	Hematopoietic cell lineage	2/1051	64/7206	0.00646859026116
ko00310	Lysine degradation	3/1051	73/7206	0.00700116829669
ko00260	Glycine, serine and threonine metabolism	1/1051	48/7206	0.00718689116948
ko04350	TGF-beta signaling pathway	6/1051	103/7206	0.00738531684246
ko00330	Arginine and proline metabolism	2/1051	61/7206	0.00932347173457
ko04217	Necroptosis	14/1051	178/7206	0.00940570498483
ko00562	Inositol phosphate metabolism	22/1051	89/7206	0.00979077481708
ko04120	Ubiquitin mediated proteolysis	10/1051	138/7206	0.0103956483066
ko00620	Pyruvate metabolism	1/1051	46/7206	0.0107084181195
ko03420	Nucleotide excision repair	1/1051	46/7206	0.0107084181195
ko05161	Hepatitis B	14/1051	173/7206	0.0119164966434
ko05162	Measles	8/1051	120/7206	0.0124115640053
ko05321	Inflammatory bowel disease (IBD)	2/1051	56/7206	0.0129612898699
ko05016	Huntington's disease	19/1051	215/7206	0.0138877031783
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1051	100/7206	0.0142023008738
ko05145	Toxoplasmosis	9/1051	126/7206	0.014955846754
ko04973	Carbohydrate digestion and absorption	12/1051	42/7206	0.0154790284051
ko03022	Basal transcription factors	1/1051	44/7206	0.0162183933626
ko05144	Malaria	1/1051	45/7206	0.0169691351356
ko00071	Fatty acid degradation	1/1051	45/7206	0.0169691351356
ko04630	Jak-STAT signaling pathway	10/1051	132/7206	0.0178750599674
ko05034	Alcoholism	48/1051	238/7206	0.0190628603389
ko04270	Vascular smooth muscle contraction	33/1051	154/7206	0.0203649100083
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1051	40/7206	0.0235517980578
ko04071	Sphingolipid signaling pathway	34/1051	162/7206	0.0240110401828
ko04140	Autophagy - animal	14/1051	164/7206	0.0248356871815
ko04214	Apoptosis - fly	4/1051	72/7206	0.0277998915975
ko04622	RIG-I-like receptor signaling pathway	3/1051	62/7206	0.0282945616185
ko05418	Fluid shear stress and atherosclerosis	15/1051	173/7206	0.0284013085327
ko04930	Type II diabetes mellitus	14/1051	54/7206	0.0303045088952
ko01200	Carbon metabolism	10/1051	128/7206	0.0306461207282
ko00982	Drug metabolism - cytochrome P450	1/1051	37/7206	0.0348532257932
ko00630	Glyoxylate and dicarboxylate metabolism	1/1051	38/7206	0.0352686617935
ko00270	Cysteine and methionine metabolism	2/1051	47/7206	0.0386436558338
ko04114	Oocyte meiosis	29/1051	139/7206	0.0389879355048
ko04658	Th1 and Th2 cell differentiation	7/1051	96/7206	0.040943948809
ko04960	Aldosterone-regulated sodium reabsorption	11/1051	41/7206	0.0414912881163
ko04657	IL-17 signaling pathway	6/1051	87/7206	0.0453257683623
ko05133	Pertussis	6/1051	87/7206	0.0453257683623
ko05231	Choline metabolism in cancer	28/1051	134/7206	0.0469331816175
ko01524	Platinum drug resistance	5/1051	76/7206	0.0487673272497
ko04144	Endocytosis	63/1051	342/7206	0.0492509497651