ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1251	423/7206	2.10184713836e-53
ko04724	Glutamatergic synapse	93/1251	152/7206	2.57596657255e-34
ko05033	Nicotine addiction	50/1251	56/7206	4.61420776621e-32
ko05032	Morphine addiction	69/1251	110/7206	1.2734570109e-26
ko04713	Circadian entrainment	78/1251	136/7206	2.8855867138e-26
ko04727	GABAergic synapse	68/1251	110/7206	1.0514344203e-25
ko04721	Synaptic vesicle cycle	55/1251	80/7206	2.25343656443e-24
ko04728	Dopaminergic synapse	85/1251	185/7206	6.22077333352e-20
ko04725	Cholinergic synapse	77/1251	160/7206	1.19477050107e-19
ko04723	Retrograde endocannabinoid signaling	79/1251	175/7206	4.95044085534e-18
ko04020	Calcium signaling pathway	104/1251	265/7206	7.68607746606e-18
ko04024	cAMP signaling pathway	105/1251	279/7206	1.62745300653e-16
ko04742	Taste transduction	39/1251	61/7206	5.64060953355e-16
ko04911	Insulin secretion	58/1251	117/7206	7.84695949516e-16
ko04744	Phototransduction	28/1251	36/7206	2.85136141379e-15
ko04921	Oxytocin signaling pathway	83/1251	209/7206	1.01883830042e-14
ko04726	Serotonergic synapse	62/1251	137/7206	1.82887412436e-14
ko04720	Long-term potentiation	49/1251	99/7206	1.5452304742e-13
ko04740	Olfactory transduction	42/1251	80/7206	6.70316173534e-13
ko05031	Amphetamine addiction	44/1251	91/7206	7.61532920622e-12
ko04970	Salivary secretion	45/1251	95/7206	1.07985122657e-11
ko03040	Spliceosome	1/1251	145/7206	4.324116219e-11
ko04261	Adrenergic signaling in cardiomyocytes	74/1251	205/7206	6.41114069999e-11
ko05168	Herpes simplex infection	5/1251	182/7206	9.41269097735e-10
ko05203	Viral carcinogenesis	15/1251	277/7206	3.15103168544e-09
ko04925	Aldosterone synthesis and secretion	43/1251	105/7206	1.04739793784e-08
ko04971	Gastric acid secretion	40/1251	98/7206	3.90412038535e-08
ko04360	Axon guidance	73/1251	233/7206	1.35013417662e-07
ko04540	Gap junction	47/1251	128/7206	1.78666829527e-07
ko04022	cGMP-PKG signaling pathway	68/1251	216/7206	2.32183121004e-07
ko03013	RNA transport	7/1251	166/7206	3.80205338705e-07
ko05030	Cocaine addiction	31/1251	73/7206	4.01121874738e-07
ko04966	Collecting duct acid secretion	16/1251	26/7206	5.75454256017e-07
ko04924	Renin secretion	34/1251	86/7206	9.17268498468e-07
ko04120	Ubiquitin mediated proteolysis	5/1251	138/7206	1.10347822099e-06
ko05164	Influenza A	8/1251	167/7206	1.32306194206e-06
ko04060	Cytokine-cytokine receptor interaction	11/1251	191/7206	2.4442745075e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1251	74/7206	2.69839653402e-06
ko05169	Epstein-Barr virus infection	13/1251	206/7206	3.65008401788e-06
ko04260	Cardiac muscle contraction	35/1251	98/7206	1.06226171309e-05
ko05322	Systemic lupus erythematosus	8/1251	151/7206	1.65982671289e-05
ko04745	Phototransduction - fly	18/1251	38/7206	1.8248890221e-05
ko04972	Pancreatic secretion	38/1251	111/7206	1.98357887525e-05
ko04730	Long-term depression	29/1251	78/7206	2.74815966656e-05
ko04514	Cell adhesion molecules (CAMs)	42/1251	130/7206	3.09594693442e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1251	79/7206	3.36070771496e-05
ko04976	Bile secretion	29/1251	80/7206	4.18833693107e-05
ko04010	MAPK signaling pathway	84/1251	321/7206	5.77055805612e-05
ko04141	Protein processing in endoplasmic reticulum	13/1251	184/7206	6.67418154003e-05
ko04621	NOD-like receptor signaling pathway	10/1251	157/7206	6.77337936992e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1251	79/7206	7.01634116578e-05
ko05110	Vibrio cholerae infection	24/1251	63/7206	7.59199810389e-05
ko05205	Proteoglycans in cancer	24/1251	271/7206	7.7243540003e-05
ko05162	Measles	6/1251	120/7206	7.80943498356e-05
ko05414	Dilated cardiomyopathy	36/1251	112/7206	0.000124160828491
ko04070	Phosphatidylinositol signaling system	36/1251	112/7206	0.000124160828491
ko04110	Cell cycle	9/1251	145/7206	0.000134290148366
ko05140	Leishmaniasis	2/1251	75/7206	0.000160847555067
ko04064	NF-kappa B signaling pathway	4/1251	96/7206	0.00018513700077
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1251	59/7206	0.000213217435503
ko04626	Plant-pathogen interaction	10/1251	18/7206	0.000272067837366
ko04146	Peroxisome	4/1251	89/7206	0.000372356263901
ko04750	Inflammatory mediator regulation of TRP channels	37/1251	122/7206	0.000395395520484
ko04610	Complement and coagulation cascades	3/1251	79/7206	0.000459204475625
ko00480	Glutathione metabolism	1/1251	55/7206	0.000527482945891
ko04964	Proximal tubule bicarbonate reclamation	13/1251	29/7206	0.000528402305483
ko05166	HTLV-I infection	30/1251	292/7206	0.000670740819331
ko04612	Antigen processing and presentation	3/1251	77/7206	0.000682120878004
ko05161	Hepatitis B	14/1251	173/7206	0.000715681900039
ko04014	Ras signaling pathway	70/1251	279/7206	0.000899512362796
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1251	14/7206	0.000900342460013
ko04072	Phospholipase D signaling pathway	52/1251	197/7206	0.00114470415939
ko00590	Arachidonic acid metabolism	1/1251	52/7206	0.00129268007082
ko04915	Estrogen signaling pathway	37/1251	131/7206	0.00159770875431
ko04371	Apelin signaling pathway	47/1251	177/7206	0.001769345592
ko03420	Nucleotide excision repair	1/1251	46/7206	0.0027870305755
ko05145	Toxoplasmosis	10/1251	126/7206	0.00292801584616
ko00240	Pyrimidine metabolism	8/1251	110/7206	0.00325418889041
ko01524	Platinum drug resistance	4/1251	76/7206	0.0033120761228
ko03022	Basal transcription factors	1/1251	44/7206	0.00425139519021
ko05144	Malaria	1/1251	45/7206	0.00449679139244
ko00071	Fatty acid degradation	1/1251	45/7206	0.00449679139244
ko04214	Apoptosis - fly	4/1251	72/7206	0.00460607794776
ko00310	Lysine degradation	4/1251	73/7206	0.00463789660219
ko05418	Fluid shear stress and atherosclerosis	17/1251	173/7206	0.00602126872423
ko04622	RIG-I-like receptor signaling pathway	3/1251	62/7206	0.00623700441268
ko04668	TNF signaling pathway	10/1251	120/7206	0.00706025824755
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1251	100/7206	0.00739999683079
ko04912	GnRH signaling pathway	33/1251	122/7206	0.00749264903423
ko03018	RNA degradation	6/1251	84/7206	0.00899935101848
ko00630	Glyoxylate and dicarboxylate metabolism	1/1251	38/7206	0.00954066206622
ko03410	Base excision repair	1/1251	38/7206	0.00954066206622
ko04630	Jak-STAT signaling pathway	12/1251	132/7206	0.0102430133914
ko04620	Toll-like receptor signaling pathway	8/1251	100/7206	0.0109529278663
ko05131	Shigellosis	6/1251	82/7206	0.0123010791157
ko05321	Inflammatory bowel disease (IBD)	3/1251	56/7206	0.0126333534757
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1251	182/7206	0.0127689479052
ko04115	p53 signaling pathway	5/1251	74/7206	0.0128159791832
ko04916	Melanogenesis	36/1251	142/7206	0.0137726421231
ko04923	Regulation of lipolysis in adipocytes	22/1251	77/7206	0.0144612293305
ko05222	Small cell lung cancer	7/1251	89/7206	0.0158599492228
ko04350	TGF-beta signaling pathway	9/1251	103/7206	0.0178542072117
ko04330	Notch signaling pathway	4/1251	62/7206	0.0181351667126
ko00600	Sphingolipid metabolism	4/1251	63/7206	0.0182303670801
ko04658	Th1 and Th2 cell differentiation	8/1251	96/7206	0.0200259288203
ko04657	IL-17 signaling pathway	7/1251	87/7206	0.0215586521442
ko05133	Pertussis	7/1251	87/7206	0.0215586521442
ko00562	Inositol phosphate metabolism	24/1251	89/7206	0.0231659050993
ko04270	Vascular smooth muscle contraction	38/1251	154/7206	0.0232201880809
ko04015	Rap1 signaling pathway	63/1251	278/7206	0.0233810674804
ko05217	Basal cell carcinoma	5/1251	68/7206	0.024276931991
ko05212	Pancreatic cancer	7/1251	83/7206	0.0284133274119
ko05132	Salmonella infection	9/1251	98/7206	0.0310046419179
ko05206	MicroRNAs in cancer	20/1251	177/7206	0.0342092336368
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1251	40/7206	0.0355776553186
ko05215	Prostate cancer	11/1251	111/7206	0.0421628315656
ko04922	Glucagon signaling pathway	31/1251	128/7206	0.0448973968242
ko05034	Alcoholism	53/1251	238/7206	0.0453575634997
ko04640	Hematopoietic cell lineage	5/1251	64/7206	0.0453842437678
ko04210	Apoptosis	21/1251	180/7206	0.0455905973819
ko05010	Alzheimer's disease	46/1251	202/7206	0.0472930439793
ko04140	Autophagy - animal	19/1251	164/7206	0.0476142508759
ko05320	Autoimmune thyroid disease	1/1251	29/7206	0.0478856482573
ko04930	Type II diabetes mellitus	15/1251	54/7206	0.0479276416716