ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	198/1203	423/7206	1.11221106156e-50
ko04724	Glutamatergic synapse	90/1203	152/7206	4.96939996218e-33
ko05033	Nicotine addiction	46/1203	56/7206	5.32141539711e-27
ko05032	Morphine addiction	68/1203	110/7206	9.49864183043e-27
ko04713	Circadian entrainment	77/1203	136/7206	1.37125069036e-26
ko04727	GABAergic synapse	65/1203	110/7206	4.91057843395e-24
ko04721	Synaptic vesicle cycle	51/1203	80/7206	3.25215218927e-21
ko04728	Dopaminergic synapse	85/1203	185/7206	4.39566723484e-21
ko04725	Cholinergic synapse	77/1203	160/7206	1.02904470317e-20
ko04020	Calcium signaling pathway	104/1203	265/7206	3.47259813891e-19
ko04723	Retrograde endocannabinoid signaling	78/1203	175/7206	1.87386805183e-18
ko04024	cAMP signaling pathway	104/1203	279/7206	3.79393970444e-17
ko04911	Insulin secretion	58/1203	117/7206	1.22210714904e-16
ko04742	Taste transduction	39/1203	61/7206	1.42056649961e-16
ko04921	Oxytocin signaling pathway	84/1203	209/7206	2.12971679483e-16
ko04726	Serotonergic synapse	62/1203	137/7206	2.74341841976e-15
ko04970	Salivary secretion	46/1203	95/7206	5.55183161715e-13
ko04261	Adrenergic signaling in cardiomyocytes	75/1203	205/7206	3.02970172379e-12
ko04720	Long-term potentiation	45/1203	99/7206	1.58538954161e-11
ko05031	Amphetamine addiction	42/1203	91/7206	4.12969378989e-11
ko03040	Spliceosome	1/1203	145/7206	1.17212530847e-10
ko04022	cGMP-PKG signaling pathway	72/1203	216/7206	1.28589410938e-09
ko04744	Phototransduction	22/1203	36/7206	2.33120367678e-09
ko04925	Aldosterone synthesis and secretion	43/1203	105/7206	2.55977702124e-09
ko04360	Axon guidance	74/1203	233/7206	9.5660455124e-09
ko04971	Gastric acid secretion	40/1203	98/7206	1.03455291098e-08
ko04740	Olfactory transduction	33/1203	80/7206	1.49639799083e-07
ko05164	Influenza A	6/1203	167/7206	1.5549355756e-07
ko05203	Viral carcinogenesis	17/1203	277/7206	1.56438255798e-07
ko04540	Gap junction	45/1203	128/7206	4.42028276234e-07
ko04924	Renin secretion	34/1203	86/7206	4.64880777467e-07
ko03013	RNA transport	7/1203	166/7206	8.59553321447e-07
ko05168	Herpes simplex infection	9/1203	182/7206	1.60873880182e-06
ko04060	Cytokine-cytokine receptor interaction	10/1203	191/7206	1.7585454341e-06
ko04972	Pancreatic secretion	39/1203	111/7206	2.01406796857e-06
ko05322	Systemic lupus erythematosus	6/1203	151/7206	2.25282371833e-06
ko04966	Collecting duct acid secretion	15/1203	26/7206	2.47557412786e-06
ko04010	MAPK signaling pathway	86/1203	321/7206	3.55083697255e-06
ko05030	Cocaine addiction	29/1203	73/7206	3.64392867473e-06
ko04514	Cell adhesion molecules (CAMs)	43/1203	130/7206	3.97965237155e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1203	74/7206	4.21645432926e-06
ko04976	Bile secretion	30/1203	80/7206	6.22566692696e-06
ko04070	Phosphatidylinositol signaling system	38/1203	112/7206	8.26270563249e-06
ko04120	Ubiquitin mediated proteolysis	6/1203	138/7206	1.39550420645e-05
ko04730	Long-term depression	28/1203	78/7206	4.04467619166e-05
ko04621	NOD-like receptor signaling pathway	9/1203	157/7206	5.05217997536e-05
ko04141	Protein processing in endoplasmic reticulum	12/1203	184/7206	5.20113829788e-05
ko04110	Cell cycle	8/1203	145/7206	6.76873188116e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1203	122/7206	6.7996655272e-05
ko05169	Epstein-Barr virus infection	15/1203	206/7206	8.80947034386e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1203	79/7206	0.000111138728879
ko05110	Vibrio cholerae infection	23/1203	63/7206	0.000123414020594
ko05414	Dilated cardiomyopathy	35/1203	112/7206	0.000160809911157
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1203	79/7206	0.000182751299486
ko04745	Phototransduction - fly	16/1203	38/7206	0.000186036911345
ko04371	Apelin signaling pathway	49/1203	177/7206	0.000205973130009
ko04014	Ras signaling pathway	70/1203	279/7206	0.00028836438662
ko04260	Cardiac muscle contraction	31/1203	98/7206	0.000296401609606
ko04072	Phospholipase D signaling pathway	53/1203	197/7206	0.000296698372925
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1203	59/7206	0.000355434932387
ko04964	Proximal tubule bicarbonate reclamation	13/1203	29/7206	0.000355706407585
ko05205	Proteoglycans in cancer	25/1203	271/7206	0.000456435027372
ko05162	Measles	7/1203	120/7206	0.000492368901398
ko04610	Complement and coagulation cascades	3/1203	79/7206	0.000694720797543
ko04915	Estrogen signaling pathway	37/1203	131/7206	0.000820281503059
ko04146	Peroxisome	4/1203	89/7206	0.000821517287595
ko04612	Antigen processing and presentation	3/1203	77/7206	0.00102112232056
ko04626	Plant-pathogen interaction	9/1203	18/7206	0.00112684246201
ko05161	Hepatitis B	14/1203	173/7206	0.00128517299793
ko04064	NF-kappa B signaling pathway	5/1203	96/7206	0.00129092043033
ko05140	Leishmaniasis	3/1203	75/7206	0.00150928159595
ko04923	Regulation of lipolysis in adipocytes	24/1203	77/7206	0.00173302318173
ko00330	Arginine and proline metabolism	2/1203	61/7206	0.00272440452048
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1203	14/7206	0.00411035309892
ko00071	Fatty acid degradation	1/1203	45/7206	0.00433780037626
ko03420	Nucleotide excision repair	1/1203	46/7206	0.0044470020598
ko05145	Toxoplasmosis	10/1203	126/7206	0.00541787988993
ko00480	Glutathione metabolism	2/1203	55/7206	0.00564029112466
ko05321	Inflammatory bowel disease (IBD)	2/1203	56/7206	0.0058659937361
ko04270	Vascular smooth muscle contraction	39/1203	154/7206	0.00599050813621
ko00240	Pyrimidine metabolism	8/1203	110/7206	0.00629558476106
ko04630	Jak-STAT signaling pathway	11/1203	132/7206	0.00664769777657
ko00310	Lysine degradation	4/1203	73/7206	0.00674263850147
ko04912	GnRH signaling pathway	32/1203	122/7206	0.00674870625821
ko03022	Basal transcription factors	1/1203	44/7206	0.00685156073957
ko04217	Necroptosis	17/1203	178/7206	0.00793527461663
ko00590	Arachidonic acid metabolism	2/1203	52/7206	0.00818540681886
ko04918	Thyroid hormone synthesis	24/1203	86/7206	0.00824356901598
ko04622	RIG-I-like receptor signaling pathway	3/1203	62/7206	0.00924061774296
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1203	100/7206	0.0095438925799
ko05166	HTLV-I infection	33/1203	292/7206	0.0102566608132
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1203	182/7206	0.0115094284805
ko04710	Circadian rhythm	14/1203	43/7206	0.0116007914146
ko00380	Tryptophan metabolism	2/1203	50/7206	0.012044054022
ko04657	IL-17 signaling pathway	6/1203	87/7206	0.0129468571234
ko05133	Pertussis	6/1203	87/7206	0.0129468571234
ko01524	Platinum drug resistance	5/1203	76/7206	0.0131225550108
ko04015	Rap1 signaling pathway	62/1203	278/7206	0.0136320698737
ko00562	Inositol phosphate metabolism	24/1203	89/7206	0.0141157924329
ko04210	Apoptosis	18/1203	180/7206	0.0146616680329
ko03410	Base excision repair	1/1203	38/7206	0.0147595185366
ko04620	Toll-like receptor signaling pathway	8/1203	100/7206	0.0150076983142
ko04930	Type II diabetes mellitus	16/1203	54/7206	0.0161299274033
ko04916	Melanogenesis	35/1203	142/7206	0.0163077664069
ko03018	RNA degradation	6/1203	84/7206	0.017462444413
ko04115	p53 signaling pathway	5/1203	74/7206	0.0180843245882
ko05222	Small cell lung cancer	7/1203	89/7206	0.0216935843805
ko05131	Shigellosis	6/1203	82/7206	0.0240484159794
ko04214	Apoptosis - fly	5/1203	72/7206	0.0249737411889
ko05144	Malaria	2/1203	45/7206	0.0254195039252
ko04330	Notch signaling pathway	4/1203	62/7206	0.0258381841894
ko00280	Valine, leucine and isoleucine degradation	3/1203	54/7206	0.0263507910977
ko04658	Th1 and Th2 cell differentiation	8/1203	96/7206	0.0266225355811
ko04640	Hematopoietic cell lineage	4/1203	64/7206	0.0266958659761
ko05215	Prostate cancer	10/1203	111/7206	0.0284927297919
ko04114	Oocyte meiosis	33/1203	139/7206	0.0288877426997
ko04922	Glucagon signaling pathway	31/1203	128/7206	0.0303607903418
ko03320	PPAR signaling pathway	5/1203	69/7206	0.0339489530182
ko05418	Fluid shear stress and atherosclerosis	19/1203	173/7206	0.0392379981992
ko05231	Choline metabolism in cancer	31/1203	134/7206	0.0471077945947
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1203	92/7206	0.0472216512735
ko04933	AGE-RAGE signaling pathway in diabetic complications	14/1203	135/7206	0.0473564633105
ko04668	TNF signaling pathway	12/1203	120/7206	0.0479667082459
ko05340	Primary immunodeficiency	1/1203	30/7206	0.0487103132401