ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	181/1179	423/7206	1.1840520665e-40
ko04724	Glutamatergic synapse	83/1179	152/7206	9.88976833569e-28
ko05033	Nicotine addiction	44/1179	56/7206	9.58581361159e-25
ko04713	Circadian entrainment	71/1179	136/7206	2.5492067653e-22
ko04020	Calcium signaling pathway	103/1179	265/7206	3.01573661161e-19
ko05032	Morphine addiction	58/1179	110/7206	1.03742002003e-18
ko04721	Synaptic vesicle cycle	47/1179	80/7206	6.33475677037e-18
ko04727	GABAergic synapse	56/1179	110/7206	3.44662128035e-17
ko04723	Retrograde endocannabinoid signaling	74/1179	175/7206	1.62219637824e-16
ko04728	Dopaminergic synapse	76/1179	185/7206	4.36086258182e-16
ko04921	Oxytocin signaling pathway	81/1179	209/7206	3.94771933929e-15
ko04725	Cholinergic synapse	66/1179	160/7206	3.1718447523e-14
ko04024	cAMP signaling pathway	96/1179	279/7206	7.48393431217e-14
ko04911	Insulin secretion	53/1179	117/7206	1.22982038231e-13
ko04726	Serotonergic synapse	55/1179	137/7206	1.67770643058e-11
ko04742	Taste transduction	32/1179	61/7206	8.06433007547e-11
ko04261	Adrenergic signaling in cardiomyocytes	70/1179	205/7206	2.83334123443e-10
ko05031	Amphetamine addiction	40/1179	91/7206	4.0280229025e-10
ko04022	cGMP-PKG signaling pathway	71/1179	216/7206	1.64179066338e-09
ko04970	Salivary secretion	40/1179	95/7206	1.91668134332e-09
ko03010	Ribosome	1/1179	129/7206	4.15343360089e-09
ko04720	Long-term potentiation	40/1179	99/7206	8.08250088433e-09
ko04744	Phototransduction	21/1179	36/7206	1.21553606843e-08
ko03040	Spliceosome	3/1179	145/7206	3.90878787499e-08
ko05322	Systemic lupus erythematosus	5/1179	151/7206	5.805095206e-07
ko04925	Aldosterone synthesis and secretion	38/1179	105/7206	7.073726114e-07
ko05168	Herpes simplex infection	8/1179	182/7206	7.27653601186e-07
ko04740	Olfactory transduction	31/1179	80/7206	1.72494821023e-06
ko04971	Gastric acid secretion	35/1179	98/7206	2.7203383074e-06
ko05203	Viral carcinogenesis	19/1179	277/7206	2.75885964696e-06
ko04730	Long-term depression	30/1179	78/7206	2.88071674716e-06
ko05164	Influenza A	8/1179	167/7206	6.25497268075e-06
ko05030	Cocaine addiction	28/1179	73/7206	6.80962719921e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1179	74/7206	8.20889379312e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1179	79/7206	9.665747918e-06
ko04966	Collecting duct acid secretion	14/1179	26/7206	1.25782295613e-05
ko04120	Ubiquitin mediated proteolysis	6/1179	138/7206	2.06302448597e-05
ko00010	Glycolysis / Gluconeogenesis	27/1179	74/7206	2.23709300662e-05
ko04260	Cardiac muscle contraction	33/1179	98/7206	2.29924282435e-05
ko04621	NOD-like receptor signaling pathway	8/1179	157/7206	2.55165840189e-05
ko03013	RNA transport	9/1179	166/7206	2.68454249409e-05
ko04110	Cell cycle	7/1179	145/7206	3.32336506658e-05
ko05162	Measles	5/1179	120/7206	5.20893335436e-05
ko04964	Proximal tubule bicarbonate reclamation	14/1179	29/7206	6.21067207798e-05
ko05414	Dilated cardiomyopathy	35/1179	112/7206	8.25623439792e-05
ko04060	Cytokine-cytokine receptor interaction	13/1179	191/7206	9.77779848266e-05
ko04371	Apelin signaling pathway	49/1179	177/7206	0.000119036668495
ko04745	Phototransduction - fly	16/1179	38/7206	0.000145725980075
ko05169	Epstein-Barr virus infection	15/1179	206/7206	0.000167711067227
ko03008	Ribosome biogenesis in eukaryotes	2/1179	79/7206	0.000171834110392
ko04514	Cell adhesion molecules (CAMs)	38/1179	130/7206	0.0001830609644
ko04710	Circadian rhythm	17/1179	43/7206	0.000229059554581
ko05161	Hepatitis B	12/1179	173/7206	0.000351456074589
ko04922	Glucagon signaling pathway	37/1179	128/7206	0.000387657090997
ko04540	Gap junction	37/1179	128/7206	0.000387657090997
ko05140	Leishmaniasis	2/1179	75/7206	0.000398192966705
ko05110	Vibrio cholerae infection	22/1179	63/7206	0.000412911032561
ko04010	MAPK signaling pathway	76/1179	321/7206	0.000495971174785
ko04141	Protein processing in endoplasmic reticulum	14/1179	184/7206	0.000557449950809
ko05410	Hypertrophic cardiomyopathy (HCM)	30/1179	100/7206	0.000564521096579
ko04924	Renin secretion	27/1179	86/7206	0.000568953211983
ko04610	Complement and coagulation cascades	3/1179	79/7206	0.00105926092451
ko04070	Phosphatidylinositol signaling system	32/1179	112/7206	0.0011053227445
ko04270	Vascular smooth muscle contraction	41/1179	154/7206	0.00125637488731
ko04064	NF-kappa B signaling pathway	5/1179	96/7206	0.00128176713072
ko00190	Oxidative phosphorylation	35/1179	127/7206	0.00144904828891
ko05010	Alzheimer's disease	50/1179	202/7206	0.00190326573471
ko00710	Carbon fixation in photosynthetic organisms	11/1179	27/7206	0.00219761487094
ko05230	Central carbon metabolism in cancer	24/1179	81/7206	0.0023323953221
ko01230	Biosynthesis of amino acids	25/1179	85/7206	0.00270775823635
ko04330	Notch signaling pathway	2/1179	62/7206	0.00274293137589
ko04750	Inflammatory mediator regulation of TRP channels	33/1179	122/7206	0.0027455759155
ko05205	Proteoglycans in cancer	27/1179	271/7206	0.00324920668154
ko04072	Phospholipase D signaling pathway	48/1179	197/7206	0.00325759894652
ko05145	Toxoplasmosis	9/1179	126/7206	0.00327756066675
ko01200	Carbon metabolism	34/1179	128/7206	0.0034655602071
ko05166	HTLV-I infection	30/1179	292/7206	0.00351379510448
ko04360	Axon guidance	55/1179	233/7206	0.00379818457834
ko03420	Nucleotide excision repair	1/1179	46/7206	0.00441431502652
ko04626	Plant-pathogen interaction	8/1179	18/7206	0.00469583442059
ko04612	Antigen processing and presentation	4/1179	77/7206	0.004845468926
ko04930	Type II diabetes mellitus	17/1179	54/7206	0.0050295269649
ko04657	IL-17 signaling pathway	5/1179	87/7206	0.0050424825686
ko04976	Bile secretion	23/1179	80/7206	0.00548924021673
ko05321	Inflammatory bowel disease (IBD)	2/1179	56/7206	0.00571790936814
ko04014	Ras signaling pathway	63/1179	279/7206	0.00625292970428
ko05200	Pathways in cancer	59/1179	492/7206	0.00651960517328
ko03022	Basal transcription factors	1/1179	44/7206	0.00669353862218
ko04350	TGF-beta signaling pathway	7/1179	103/7206	0.00671150536571
ko01524	Platinum drug resistance	4/1179	76/7206	0.0071380665744
ko00680	Methane metabolism	12/1179	34/7206	0.00794041629992
ko04630	Jak-STAT signaling pathway	11/1179	132/7206	0.00888656163765
ko04972	Pancreatic secretion	29/1179	111/7206	0.00902760317662
ko04622	RIG-I-like receptor signaling pathway	3/1179	62/7206	0.00922078825418
ko04214	Apoptosis - fly	4/1179	72/7206	0.00964857373137
ko00220	Arginine biosynthesis	9/1179	24/7206	0.0103124446716
ko04210	Apoptosis	17/1179	180/7206	0.0103501504491
ko00590	Arachidonic acid metabolism	2/1179	52/7206	0.0126596852839
ko05133	Pertussis	6/1179	87/7206	0.0127958560538
ko00030	Pentose phosphate pathway	11/1179	32/7206	0.0131743197871
ko05222	Small cell lung cancer	6/1179	89/7206	0.0132078466457
ko01040	Biosynthesis of unsaturated fatty acids	9/1179	25/7206	0.0138248626868
ko00471	D-Glutamine and D-glutamate metabolism	3/1179	4/7206	0.0153414347823
ko04915	Estrogen signaling pathway	32/1179	131/7206	0.016527907556
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1179	14/7206	0.0173825035504
ko00240	Pyrimidine metabolism	9/1179	110/7206	0.0186162001924
ko04550	Signaling pathways regulating pluripotency of stem cells	16/1179	165/7206	0.0186824231398
ko05215	Prostate cancer	9/1179	111/7206	0.0189660971672
ko04620	Toll-like receptor signaling pathway	8/1179	100/7206	0.0202077072462
ko04217	Necroptosis	18/1179	178/7206	0.0234195996134
ko05131	Shigellosis	6/1179	82/7206	0.0236275476723
ko00280	Valine, leucine and isoleucine degradation	3/1179	54/7206	0.0264269199152
ko00520	Amino sugar and nucleotide sugar metabolism	3/1179	55/7206	0.0265951224113
ko00480	Glutathione metabolism	3/1179	55/7206	0.0265951224113
ko04146	Peroxisome	7/1179	89/7206	0.0294993696659
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1179	59/7206	0.0327764427859
ko04140	Autophagy - animal	17/1179	164/7206	0.032917486956
ko04960	Aldosterone-regulated sodium reabsorption	12/1179	41/7206	0.0331455961671
ko04668	TNF signaling pathway	11/1179	120/7206	0.0334804489094
ko00860	Porphyrin and chlorophyll metabolism	1/1179	34/7206	0.0335440934315
ko04658	Th1 and Th2 cell differentiation	8/1179	96/7206	0.0358768438996
ko05220	Chronic myeloid leukemia	7/1179	85/7206	0.0389969408602
ko05206	MicroRNAs in cancer	19/1179	177/7206	0.0395488401057
ko00562	Inositol phosphate metabolism	22/1179	89/7206	0.042138964597
ko00620	Pyruvate metabolism	13/1179	46/7206	0.042440950095
ko05130	Pathogenic Escherichia coli infection	6/1179	77/7206	0.0429095493564
ko04711	Circadian rhythm - fly	5/1179	13/7206	0.0475502557076
ko00230	Purine metabolism	42/1179	194/7206	0.0488352928468
ko05340	Primary immunodeficiency	1/1179	30/7206	0.0492720554207