ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 39/326 191/7206 5.89199832254e-16 ko04380 Osteoclast differentiation 31/326 134/7206 1.86853499264e-14 ko04621 NOD-like receptor signaling pathway 33/326 157/7206 4.97960046791e-14 ko05164 Influenza A 32/326 167/7206 1.81184028613e-12 ko04064 NF-kappa B signaling pathway 23/326 96/7206 2.34396771465e-11 ko04668 TNF signaling pathway 25/326 120/7206 8.206987244e-11 ko05168 Herpes simplex infection 29/326 182/7206 2.08613444593e-09 ko05162 Measles 23/326 120/7206 2.71809272007e-09 ko05161 Hepatitis B 27/326 173/7206 1.22145195894e-08 ko05140 Leishmaniasis 17/326 75/7206 2.49249725895e-08 ko05145 Toxoplasmosis 22/326 126/7206 3.64718231031e-08 ko04217 Necroptosis 26/326 178/7206 9.23123476284e-08 ko05321 Inflammatory bowel disease (IBD) 14/326 56/7206 1.17730472282e-07 ko04657 IL-17 signaling pathway 17/326 87/7206 2.52885338102e-07 ko04650 Natural killer cell mediated cytotoxicity 18/326 97/7206 2.5377041529e-07 ko04622 RIG-I-like receptor signaling pathway 14/326 62/7206 4.60664350582e-07 ko05152 Tuberculosis 25/326 187/7206 9.20151260267e-07 ko05133 Pertussis 16/326 87/7206 1.35166106069e-06 ko04620 Toll-like receptor signaling pathway 17/326 100/7206 1.9856212353e-06 ko05160 Hepatitis C 21/326 153/7206 4.59845888403e-06 ko04630 Jak-STAT signaling pathway 19/326 132/7206 6.51717707688e-06 ko04623 Cytosolic DNA-sensing pathway 10/326 41/7206 1.00137707853e-05 ko04660 T cell receptor signaling pathway 18/326 124/7206 1.01436719803e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/326 191/7206 1.50487515089e-05 ko04659 Th17 cell differentiation 16/326 106/7206 1.92127010448e-05 ko04658 Th1 and Th2 cell differentiation 15/326 96/7206 2.29807510007e-05 ko04672 Intestinal immune network for IgA production 9/326 37/7206 2.87483209608e-05 ko05330 Allograft rejection 7/326 24/7206 6.46110786909e-05 ko04662 B cell receptor signaling pathway 13/326 88/7206 0.000145628091147 ko05323 Rheumatoid arthritis 13/326 89/7206 0.000163718768747 ko04210 Apoptosis 20/326 180/7206 0.000168870971725 ko05131 Shigellosis 12/326 82/7206 0.000285968442794 ko05340 Primary immunodeficiency 7/326 30/7206 0.000300571914646 ko05132 Salmonella infection 13/326 98/7206 0.000433568699373 ko05134 Legionellosis 11/326 74/7206 0.000444365358273 ko05310 Asthma 5/326 17/7206 0.000724811216019 ko05142 Chagas disease (American trypanosomiasis) 15/326 130/7206 0.000735785517127 ko05144 Malaria 8/326 45/7206 0.000800182670043 ko05332 Graft-versus-host disease 5/326 18/7206 0.000966767137012 ko05150 Staphylococcus aureus infection 7/326 36/7206 0.000975641859982 ko04666 Fc gamma R-mediated phagocytosis 14/326 122/7206 0.00115836712612 ko05320 Autoimmune thyroid disease 6/326 29/7206 0.00160682267008 ko04664 Fc epsilon RI signaling pathway 10/326 77/7206 0.00230724648589 ko04940 Type I diabetes mellitus 6/326 32/7206 0.00273427687205 ko04610 Complement and coagulation cascades 10/326 79/7206 0.00279780679438 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/326 135/7206 0.00486036559165 ko05146 Amoebiasis 11/326 99/7206 0.00490584402784 ko04062 Chemokine signaling pathway 18/326 201/7206 0.00508732897792 ko04550 Signaling pathways regulating pluripotency of stem cells 1/326 165/7206 0.00710574490798 ko04612 Antigen processing and presentation 9/326 77/7206 0.00761036815966 ko04640 Hematopoietic cell lineage 8/326 64/7206 0.00780773722496 ko05012 Parkinson's disease 1/326 155/7206 0.0102787889037 ko04931 Insulin resistance 13/326 137/7206 0.0105333681207 ko00051 Fructose and mannose metabolism 6/326 42/7206 0.0108390882863 ko05169 Epstein-Barr virus infection 17/326 206/7206 0.0156494610972 ko04728 Dopaminergic synapse 2/326 185/7206 0.0179732656602 ko04390 Hippo signaling pathway 2/326 188/7206 0.0185436805692 ko04920 Adipocytokine signaling pathway 9/326 89/7206 0.0187348969953 ko05166 HTLV-I infection 22/326 292/7206 0.0199622576228 ko04726 Serotonergic synapse 1/326 137/7206 0.0214873044409 ko04713 Circadian entrainment 1/326 136/7206 0.021499183979 ko05034 Alcoholism 4/326 238/7206 0.0259003356661 ko04670 Leukocyte transendothelial migration 13/326 151/7206 0.0260484471268 ko00190 Oxidative phosphorylation 1/326 127/7206 0.0309882295511 ko04360 Axon guidance 4/326 233/7206 0.0354339581202 ko00140 Steroid hormone biosynthesis 5/326 41/7206 0.03624332004 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/326 92/7206 0.0365247571052 ko05416 Viral myocarditis 6/326 55/7206 0.036825315537 ko04932 Non-alcoholic fatty liver disease (NAFLD) 14/326 182/7206 0.0455227508906