ko pathway ratio_in_study ratio_in_pop p_value ko04713 Circadian entrainment 35/408 136/7206 1.06108454436e-14 ko04724 Glutamatergic synapse 35/408 152/7206 3.90431427535e-13 ko04721 Synaptic vesicle cycle 25/408 80/7206 6.56999333437e-13 ko04728 Dopaminergic synapse 36/408 185/7206 3.48855436436e-11 ko04911 Insulin secretion 28/408 117/7206 3.60904903002e-11 ko05033 Nicotine addiction 19/408 56/7206 8.16231156759e-11 ko04727 GABAergic synapse 25/408 110/7206 1.34813581665e-09 ko04024 cAMP signaling pathway 40/408 279/7206 3.51086781336e-08 ko04723 Retrograde endocannabinoid signaling 30/408 175/7206 3.55515410264e-08 ko04261 Adrenergic signaling in cardiomyocytes 33/408 205/7206 3.56128991215e-08 ko04970 Salivary secretion 21/408 95/7206 4.86494348756e-08 ko04745 Phototransduction - fly 13/408 38/7206 7.51351212451e-08 ko04725 Cholinergic synapse 27/408 160/7206 2.44603953014e-07 ko04720 Long-term potentiation 20/408 99/7206 4.86242346859e-07 ko05032 Morphine addiction 21/408 110/7206 6.79292736879e-07 ko05031 Amphetamine addiction 18/408 91/7206 2.51901611423e-06 ko04921 Oxytocin signaling pathway 29/408 209/7206 5.65941319816e-06 ko04022 cGMP-PKG signaling pathway 29/408 216/7206 1.36872357533e-05 ko04744 Phototransduction 10/408 36/7206 2.03844625695e-05 ko04925 Aldosterone synthesis and secretion 17/408 105/7206 7.36677835269e-05 ko04020 Calcium signaling pathway 31/408 265/7206 0.000106456165167 ko04514 Cell adhesion molecules (CAMs) 19/408 130/7206 0.000117892126549 ko04080 Neuroactive ligand-receptor interaction 43/408 423/7206 0.000187929435227 ko05030 Cocaine addiction 13/408 73/7206 0.000194610185829 ko04924 Renin secretion 14/408 86/7206 0.000297820112437 ko04626 Plant-pathogen interaction 6/408 18/7206 0.000328959865906 ko04971 Gastric acid secretion 15/408 98/7206 0.000365958260512 ko04730 Long-term depression 13/408 78/7206 0.000384240495068 ko04972 Pancreatic secretion 16/408 111/7206 0.000471875260574 ko05014 Amyotrophic lateral sclerosis (ALS) 12/408 74/7206 0.000825013921622 ko05010 Alzheimer's disease 23/408 202/7206 0.00159645320409 ko04726 Serotonergic synapse 17/408 137/7206 0.00209832643541 ko05203 Viral carcinogenesis 5/408 277/7206 0.00210684208282 ko04060 Cytokine-cytokine receptor interaction 2/408 191/7206 0.00213189569725 ko05110 Vibrio cholerae infection 10/408 63/7206 0.00260185848176 ko04966 Collecting duct acid secretion 6/408 26/7206 0.00277315005067 ko05168 Herpes simplex infection 2/408 182/7206 0.00299966836444 ko04260 Cardiac muscle contraction 13/408 98/7206 0.00334939924243 ko05322 Systemic lupus erythematosus 1/408 151/7206 0.00349339415695 ko04964 Proximal tubule bicarbonate reclamation 6/408 29/7206 0.00495511389296 ko04740 Olfactory transduction 11/408 80/7206 0.00511752046867 ko04961 Endocrine and other factor-regulated calcium reabsorption 9/408 59/7206 0.00551511361627 ko04973 Carbohydrate digestion and absorption 7/408 42/7206 0.0085386139707 ko04360 Axon guidance 23/408 233/7206 0.0086991543601 ko04070 Phosphatidylinositol signaling system 13/408 112/7206 0.0117467377651 ko04114 Oocyte meiosis 15/408 139/7206 0.0144311241809 ko05162 Measles 1/408 120/7206 0.0148122991682 ko05120 Epithelial cell signaling in Helicobacter pylori infection 11/408 92/7206 0.0188645120734 ko05205 Proteoglycans in cancer 7/408 271/7206 0.0220399864318 ko04120 Ubiquitin mediated proteolysis 2/408 138/7206 0.0243491332678 ko03013 RNA transport 3/408 166/7206 0.0257114331342 ko05164 Influenza A 3/408 167/7206 0.0258733891264 ko04960 Aldosterone-regulated sodium reabsorption 6/408 41/7206 0.0265282185364 ko04750 Inflammatory mediator regulation of TRP channels 13/408 122/7206 0.026634824497 ko05166 HTLV-I infection 8/408 292/7206 0.026885471096 ko04810 Regulation of actin cytoskeleton 7/408 264/7206 0.029007655281 ko04930 Type II diabetes mellitus 7/408 54/7206 0.0314411343976 ko04510 Focal adhesion 6/408 240/7206 0.0315897334695 ko04940 Type I diabetes mellitus 5/408 32/7206 0.0322999781941 ko04922 Glucagon signaling pathway 13/408 128/7206 0.0334135547748 ko04630 Jak-STAT signaling pathway 2/408 132/7206 0.0344047828012 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/408 14/7206 0.0411354978594 ko02024 Quorum sensing 3/408 15/7206 0.0493219487331 ko01040 Biosynthesis of unsaturated fatty acids 4/408 25/7206 0.0498455217172