ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 31/363 191/7206 4.95128915182e-09 ko04380 Osteoclast differentiation 22/363 134/7206 7.41719642547e-07 ko05144 Malaria 12/363 45/7206 1.41550864771e-06 ko04610 Complement and coagulation cascades 16/363 79/7206 1.4488925406e-06 ko05150 Staphylococcus aureus infection 10/363 36/7206 7.28491716958e-06 ko04611 Platelet activation 21/363 163/7206 6.25620886116e-05 ko04650 Natural killer cell mediated cytotoxicity 15/363 97/7206 9.0013717872e-05 ko04933 AGE-RAGE signaling pathway in diabetic complications 18/363 135/7206 0.000134052410256 ko05162 Measles 16/363 120/7206 0.000314072476963 ko04072 Phospholipase D signaling pathway 22/363 197/7206 0.000381828879417 ko05164 Influenza A 20/363 167/7206 0.000417093984136 ko04662 B cell receptor signaling pathway 13/363 88/7206 0.000418114546843 ko04510 Focal adhesion 25/363 240/7206 0.000459356141972 ko04512 ECM-receptor interaction 12/363 79/7206 0.000534607430209 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/363 191/7206 0.00062930508721 ko04630 Jak-STAT signaling pathway 16/363 132/7206 0.00091770508834 ko04668 TNF signaling pathway 15/363 120/7206 0.000957013731126 ko04658 Th1 and Th2 cell differentiation 13/363 96/7206 0.000976324361399 ko04064 NF-kappa B signaling pathway 13/363 96/7206 0.000976324361399 ko04621 NOD-like receptor signaling pathway 18/363 157/7206 0.0011459850794 ko04066 HIF-1 signaling pathway 15/363 123/7206 0.0012364810706 ko04620 Toll-like receptor signaling pathway 13/363 100/7206 0.00143386882014 ko05323 Rheumatoid arthritis 12/363 89/7206 0.00157517642659 ko05321 Inflammatory bowel disease (IBD) 9/363 56/7206 0.0017481891343 ko05166 HTLV-I infection 27/363 292/7206 0.00227611195749 ko04659 Th17 cell differentiation 13/363 106/7206 0.00244369362575 ko04974 Protein digestion and absorption 12/363 96/7206 0.00302126191514 ko05340 Primary immunodeficiency 6/363 30/7206 0.00332430430954 ko04622 RIG-I-like receptor signaling pathway 9/363 62/7206 0.00358920799897 ko05034 Alcoholism 3/363 238/7206 0.00363350565467 ko05418 Fluid shear stress and atherosclerosis 18/363 173/7206 0.00385889674674 ko04670 Leukocyte transendothelial migration 16/363 151/7206 0.00411141926142 ko05160 Hepatitis C 16/363 153/7206 0.00459347668492 ko04015 Rap1 signaling pathway 25/363 278/7206 0.00460965495906 ko05145 Toxoplasmosis 14/363 126/7206 0.00565211425793 ko04151 PI3K-Akt signaling pathway 32/363 390/7206 0.00580170746171 ko04514 Cell adhesion molecules (CAMs) 14/363 130/7206 0.00675919476353 ko04270 Vascular smooth muscle contraction 16/363 154/7206 0.00752928595301 ko04672 Intestinal immune network for IgA production 6/363 37/7206 0.00967775013505 ko03040 Spliceosome 1/363 145/7206 0.0107015666619 ko04110 Cell cycle 1/363 145/7206 0.0107015666619 ko04660 T cell receptor signaling pathway 13/363 124/7206 0.0108895370379 ko05134 Legionellosis 9/363 74/7206 0.0115287247744 ko00950 Isoquinoline alkaloid biosynthesis 3/363 10/7206 0.0116722090498 ko05140 Leishmaniasis 9/363 75/7206 0.0125388177601 ko04723 Retrograde endocannabinoid signaling 2/363 175/7206 0.0127197955763 ko04922 Glucagon signaling pathway 13/363 128/7206 0.0132888543638 ko00592 alpha-Linolenic acid metabolism 4/363 19/7206 0.0134426707201 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/363 4/7206 0.0141901985455 ko04640 Hematopoietic cell lineage 8/363 64/7206 0.0143867801699 ko05142 Chagas disease (American trypanosomiasis) 13/363 130/7206 0.0147182455982 ko04664 Fc epsilon RI signaling pathway 9/363 77/7206 0.0147547501475 ko04022 cGMP-PKG signaling pathway 19/363 216/7206 0.0165790114481 ko03013 RNA transport 2/363 166/7206 0.0177957566572 ko04710 Circadian rhythm 6/363 43/7206 0.0197229700759 ko05161 Hepatitis B 16/363 173/7206 0.019804042139 ko04666 Fc gamma R-mediated phagocytosis 12/363 122/7206 0.0212718920694 ko05131 Shigellosis 9/363 82/7206 0.0215426643943 ko03320 PPAR signaling pathway 8/363 69/7206 0.0218945078675 ko03010 Ribosome 1/363 129/7206 0.0223199555098 ko05168 Herpes simplex infection 16/363 182/7206 0.0251907481636 ko04728 Dopaminergic synapse 3/363 185/7206 0.025845854924 ko05132 Salmonella infection 10/363 98/7206 0.0312675851358 ko00330 Arginine and proline metabolism 7/363 61/7206 0.0326458088367 ko00561 Glycerolipid metabolism 7/363 63/7206 0.038041473116 ko05222 Small cell lung cancer 9/363 89/7206 0.0442205786782 ko00710 Carbon fixation in photosynthetic organisms 4/363 27/7206 0.0444321477546 ko04972 Pancreatic secretion 1/363 111/7206 0.045105084828 ko00590 Arachidonic acid metabolism 6/363 52/7206 0.0452782617084