ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1248	423/7206	2.66569806627e-47
ko04724	Glutamatergic synapse	91/1248	152/7206	1.28979495215e-32
ko05033	Nicotine addiction	49/1248	56/7206	1.4585274964e-30
ko05032	Morphine addiction	71/1248	110/7206	1.41969421716e-28
ko04727	GABAergic synapse	70/1248	110/7206	1.27244160018e-27
ko04713	Circadian entrainment	75/1248	136/7206	6.70732755459e-24
ko04721	Synaptic vesicle cycle	52/1248	80/7206	1.98883513138e-21
ko04728	Dopaminergic synapse	87/1248	185/7206	2.72145616822e-21
ko04725	Cholinergic synapse	76/1248	160/7206	4.76093799352e-19
ko04723	Retrograde endocannabinoid signaling	80/1248	175/7206	1.01404890349e-18
ko04024	cAMP signaling pathway	103/1248	279/7206	1.32755946301e-15
ko04742	Taste transduction	38/1248	61/7206	4.3521046455e-15
ko04911	Insulin secretion	56/1248	117/7206	1.57904806347e-14
ko04744	Phototransduction	27/1248	36/7206	4.09463290001e-14
ko04726	Serotonergic synapse	61/1248	137/7206	6.65055662833e-14
ko04020	Calcium signaling pathway	93/1248	265/7206	1.11889743709e-12
ko04921	Oxytocin signaling pathway	77/1248	209/7206	6.58878430452e-12
ko05031	Amphetamine addiction	42/1248	91/7206	1.38713786678e-10
ko04261	Adrenergic signaling in cardiomyocytes	73/1248	205/7206	2.0964678378e-10
ko04740	Olfactory transduction	38/1248	80/7206	3.72298116093e-10
ko03040	Spliceosome	2/1248	145/7206	5.9923824636e-10
ko04720	Long-term potentiation	42/1248	99/7206	3.41561842467e-09
ko04970	Salivary secretion	40/1248	95/7206	1.04990220922e-08
ko05203	Viral carcinogenesis	17/1248	277/7206	3.77156454877e-08
ko04925	Aldosterone synthesis and secretion	41/1248	105/7206	1.32159764323e-07
ko03013	RNA transport	7/1248	166/7206	3.78314152902e-07
ko05030	Cocaine addiction	31/1248	73/7206	3.79595954895e-07
ko05322	Systemic lupus erythematosus	6/1248	151/7206	6.53754853651e-07
ko05168	Herpes simplex infection	9/1248	182/7206	7.46141391273e-07
ko04971	Gastric acid secretion	37/1248	98/7206	1.16833597924e-06
ko04966	Collecting duct acid secretion	15/1248	26/7206	3.99302212292e-06
ko04621	NOD-like receptor signaling pathway	8/1248	157/7206	5.56705822915e-06
ko04360	Axon guidance	68/1248	233/7206	5.62869991001e-06
ko05164	Influenza A	9/1248	167/7206	6.1792239266e-06
ko04060	Cytokine-cytokine receptor interaction	12/1248	191/7206	9.87916901281e-06
ko04745	Phototransduction - fly	18/1248	38/7206	1.76353964889e-05
ko04064	NF-kappa B signaling pathway	3/1248	96/7206	3.05994364155e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1248	74/7206	3.17029079523e-05
ko04070	Phosphatidylinositol signaling system	37/1248	112/7206	4.27716582573e-05
ko04022	cGMP-PKG signaling pathway	61/1248	216/7206	5.07758566604e-05
ko04514	Cell adhesion molecules (CAMs)	41/1248	130/7206	5.71496969282e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1248	79/7206	7.02967654866e-05
ko04072	Phospholipase D signaling pathway	56/1248	197/7206	8.06608839114e-05
ko04120	Ubiquitin mediated proteolysis	8/1248	138/7206	9.06195430022e-05
ko05161	Hepatitis B	12/1248	173/7206	9.34542465415e-05
ko04972	Pancreatic secretion	36/1248	111/7206	0.000110354798159
ko04110	Cell cycle	9/1248	145/7206	0.000132989906074
ko04976	Bile secretion	28/1248	80/7206	0.000136803660362
ko04141	Protein processing in endoplasmic reticulum	14/1248	184/7206	0.000159963168883
ko05140	Leishmaniasis	2/1248	75/7206	0.000160168722769
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1248	79/7206	0.0002525555629
ko04010	MAPK signaling pathway	81/1248	321/7206	0.000271287417493
ko05110	Vibrio cholerae infection	23/1248	63/7206	0.000286430503792
ko05162	Measles	7/1248	120/7206	0.000344553614856
ko04610	Complement and coagulation cascades	3/1248	79/7206	0.000458234431086
ko04924	Renin secretion	28/1248	86/7206	0.000487119594947
ko05169	Epstein-Barr virus infection	18/1248	206/7206	0.000509949935276
ko00520	Amino sugar and nucleotide sugar metabolism	1/1248	55/7206	0.000529582179826
ko04730	Long-term depression	26/1248	78/7206	0.00071765378716
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1248	59/7206	0.0007320370962
ko04260	Cardiac muscle contraction	30/1248	98/7206	0.00109131601561
ko04540	Gap junction	37/1248	128/7206	0.0012857920744
ko05205	Proteoglycans in cancer	28/1248	271/7206	0.00135989621642
ko05414	Dilated cardiomyopathy	33/1248	112/7206	0.00144719272134
ko04626	Plant-pathogen interaction	9/1248	18/7206	0.00148048449046
ko05166	HTLV-I infection	31/1248	292/7206	0.0015199891072
ko04915	Estrogen signaling pathway	37/1248	131/7206	0.00155857276188
ko04964	Proximal tubule bicarbonate reclamation	12/1248	29/7206	0.00197738755519
ko04612	Antigen processing and presentation	4/1248	77/7206	0.0022821747425
ko03420	Nucleotide excision repair	1/1248	46/7206	0.00278860786053
ko04510	Focal adhesion	25/1248	240/7206	0.00308282855876
ko00240	Pyrimidine metabolism	8/1248	110/7206	0.00325350525551
ko04923	Regulation of lipolysis in adipocytes	24/1248	77/7206	0.00344330436026
ko04014	Ras signaling pathway	67/1248	279/7206	0.00359498137539
ko00480	Glutathione metabolism	2/1248	55/7206	0.00369268272373
ko05321	Inflammatory bowel disease (IBD)	2/1248	56/7206	0.00379169395298
ko05145	Toxoplasmosis	10/1248	126/7206	0.00401748333571
ko03022	Basal transcription factors	1/1248	44/7206	0.00424609713032
ko05144	Malaria	1/1248	45/7206	0.00447102727069
ko04115	p53 signaling pathway	4/1248	74/7206	0.00476491553529
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1248	14/7206	0.0050895192999
ko00590	Arachidonic acid metabolism	2/1248	52/7206	0.00543105335946
ko04622	RIG-I-like receptor signaling pathway	3/1248	62/7206	0.0062255048113
ko04658	Th1 and Th2 cell differentiation	7/1248	96/7206	0.0063085236458
ko04657	IL-17 signaling pathway	6/1248	87/7206	0.00653807611769
ko05133	Pertussis	6/1248	87/7206	0.00653807611769
ko04210	Apoptosis	18/1248	180/7206	0.00690834990407
ko04710	Circadian rhythm	15/1248	43/7206	0.00693696363001
ko04750	Inflammatory mediator regulation of TRP channels	33/1248	122/7206	0.00741700455553
ko04217	Necroptosis	18/1248	178/7206	0.00883544942926
ko04630	Jak-STAT signaling pathway	12/1248	132/7206	0.0102219638264
ko04930	Type II diabetes mellitus	17/1248	54/7206	0.0102887217614
ko04371	Apelin signaling pathway	44/1248	177/7206	0.0114845329192
ko05131	Shigellosis	6/1248	82/7206	0.0123267976016
ko03018	RNA degradation	6/1248	84/7206	0.0126782704952
ko05016	Huntington's disease	24/1248	215/7206	0.0134192174094
ko04711	Circadian rhythm - fly	6/1248	13/7206	0.0151613313562
ko04146	Peroxisome	7/1248	89/7206	0.0158405506504
ko04214	Apoptosis - fly	5/1248	72/7206	0.0178146659586
ko04330	Notch signaling pathway	4/1248	62/7206	0.0181817356456
ko00860	Porphyrin and chlorophyll metabolism	1/1248	34/7206	0.0215020450297
ko05202	Transcriptional misregulation in cancer	21/1248	188/7206	0.0242527157544
ko03320	PPAR signaling pathway	5/1248	69/7206	0.0243353777303
ko04922	Glucagon signaling pathway	32/1248	128/7206	0.0248647989025
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1248	100/7206	0.0319618692337
ko05222	Small cell lung cancer	8/1248	89/7206	0.0343670033202
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1248	40/7206	0.0356197226462
ko04973	Carbohydrate digestion and absorption	13/1248	42/7206	0.0375060653082
ko04912	GnRH signaling pathway	30/1248	122/7206	0.0395283617998
ko05418	Fluid shear stress and atherosclerosis	20/1248	173/7206	0.0419431361812
ko04640	Hematopoietic cell lineage	5/1248	64/7206	0.0453632696559
ko00562	Inositol phosphate metabolism	23/1248	89/7206	0.0468287996818
ko05320	Autoimmune thyroid disease	1/1248	29/7206	0.0479116231545
ko05200	Pathways in cancer	69/1248	492/7206	0.0480906450076
ko04142	Lysosome	17/1248	151/7206	0.0498630758944