ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 41/332 152/7206 3.28252654799e-21 ko04080 Neuroactive ligand-receptor interaction 57/332 423/7206 6.34121236569e-14 ko04020 Calcium signaling pathway 42/332 265/7206 8.34414519216e-13 ko04713 Circadian entrainment 28/332 136/7206 1.20511114708e-11 ko04261 Adrenergic signaling in cardiomyocytes 34/332 205/7206 4.13211853021e-11 ko04720 Long-term potentiation 23/332 99/7206 6.6920713443e-11 ko04911 Insulin secretion 25/332 117/7206 6.80757224043e-11 ko04723 Retrograde endocannabinoid signaling 30/332 175/7206 2.69075391458e-10 ko04728 Dopaminergic synapse 30/332 185/7206 1.0882762545e-09 ko05033 Nicotine addiction 16/332 56/7206 2.23367928865e-09 ko04921 Oxytocin signaling pathway 31/332 209/7206 5.33571949863e-09 ko04024 cAMP signaling pathway 36/332 279/7206 1.35979460885e-08 ko05032 Morphine addiction 21/332 110/7206 2.02311849263e-08 ko05031 Amphetamine addiction 19/332 91/7206 2.11272711486e-08 ko04925 Aldosterone synthesis and secretion 20/332 105/7206 4.61788713871e-08 ko04727 GABAergic synapse 20/332 110/7206 1.04093535549e-07 ko05414 Dilated cardiomyopathy 20/332 112/7206 1.420395147e-07 ko04725 Cholinergic synapse 24/332 160/7206 2.48146602172e-07 ko04915 Estrogen signaling pathway 20/332 131/7206 1.92574527662e-06 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/332 79/7206 2.39548496145e-06 ko04742 Taste transduction 13/332 61/7206 2.94543620735e-06 ko04072 Phospholipase D signaling pathway 25/332 197/7206 3.39833788504e-06 ko05030 Cocaine addiction 14/332 73/7206 4.61002778277e-06 ko04970 Salivary secretion 16/332 95/7206 5.72291840673e-06 ko04971 Gastric acid secretion 16/332 98/7206 8.66351389791e-06 ko04912 GnRH signaling pathway 17/332 122/7206 3.89778866272e-05 ko04972 Pancreatic secretion 16/332 111/7206 4.31721155238e-05 ko04070 Phosphatidylinositol signaling system 16/332 112/7206 4.82959729995e-05 ko04022 cGMP-PKG signaling pathway 24/332 216/7206 8.29204388397e-05 ko04726 Serotonergic synapse 17/332 137/7206 0.000170243066562 ko04923 Regulation of lipolysis in adipocytes 12/332 77/7206 0.000184452914518 ko04740 Olfactory transduction 12/332 80/7206 0.000267064881829 ko04750 Inflammatory mediator regulation of TRP channels 15/332 122/7206 0.000451368135868 ko04010 MAPK signaling pathway 29/332 321/7206 0.000517541487452 ko04114 Oocyte meiosis 16/332 139/7206 0.000619130521833 ko05410 Hypertrophic cardiomyopathy (HCM) 13/332 100/7206 0.000628460079035 ko04721 Synaptic vesicle cycle 11/332 80/7206 0.00101596314628 ko04371 Apelin signaling pathway 18/332 177/7206 0.00148101768767 ko04260 Cardiac muscle contraction 12/332 98/7206 0.00171249819468 ko00512 Mucin type O-glycan biosynthesis 6/332 29/7206 0.0017643274401 ko05014 Amyotrophic lateral sclerosis (ALS) 10/332 74/7206 0.00195055536168 ko04060 Cytokine-cytokine receptor interaction 1/332 191/7206 0.00235391577903 ko00562 Inositol phosphate metabolism 11/332 89/7206 0.00244885442321 ko04914 Progesterone-mediated oocyte maturation 12/332 104/7206 0.00284698421032 ko04012 ErbB signaling pathway 12/332 109/7206 0.00420297664151 ko00515 Mannose type O-glycan biosynthesis 5/332 25/7206 0.00499345272691 ko04270 Vascular smooth muscle contraction 15/332 154/7206 0.00539926625576 ko04213 Longevity regulating pathway - multiple species 10/332 86/7206 0.00590721729776 ko04924 Renin secretion 10/332 86/7206 0.00590721729776 ko04918 Thyroid hormone synthesis 10/332 86/7206 0.00590721729776 ko04916 Melanogenesis 14/332 142/7206 0.00679979316149 ko04745 Phototransduction - fly 6/332 38/7206 0.00723835726971 ko05203 Viral carcinogenesis 4/332 277/7206 0.00764843391054 ko04540 Gap junction 13/332 128/7206 0.00814253620442 ko04730 Long-term depression 9/332 78/7206 0.00927035715355 ko05214 Glioma 9/332 79/7206 0.0100518399012 ko04142 Lysosome 1/332 151/7206 0.0102669390003 ko05231 Choline metabolism in cancer 13/332 134/7206 0.0102787848168 ko00513 Various types of N-glycan biosynthesis 6/332 42/7206 0.0117935220379 ko04014 Ras signaling pathway 22/332 279/7206 0.0124805510063 ko04211 Longevity regulating pathway 12/332 123/7206 0.0137496836884 ko01522 Endocrine resistance 12/332 124/7206 0.0142988020777 ko04360 Axon guidance 19/332 233/7206 0.0156166161198 ko05213 Endometrial cancer 7/332 62/7206 0.0230912384253 ko04913 Ovarian steroidogenesis 7/332 63/7206 0.0249900969416 ko00510 N-Glycan biosynthesis 6/332 50/7206 0.0263169082274 ko04015 Rap1 signaling pathway 21/332 278/7206 0.0268862247739 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 4/332 26/7206 0.0296605671433 ko04976 Bile secretion 8/332 80/7206 0.0302488032968 ko04145 Phagosome 2/332 162/7206 0.034981135777 ko03013 RNA transport 2/332 166/7206 0.0360969288392 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 4/332 28/7206 0.0378193771591 ko04141 Protein processing in endoplasmic reticulum 3/332 184/7206 0.0488941461562 ko05202 Transcriptional misregulation in cancer 3/332 188/7206 0.0497047962149