ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 47/323 191/7206 6.91716527384e-23 ko04650 Natural killer cell mediated cytotoxicity 25/323 97/7206 4.1776447962e-13 ko05152 Tuberculosis 34/323 187/7206 1.29939411762e-12 ko05321 Inflammatory bowel disease (IBD) 19/323 56/7206 1.32819544135e-12 ko04380 Osteoclast differentiation 28/323 134/7206 4.2251948272e-12 ko05140 Leishmaniasis 21/323 75/7206 5.85318596241e-12 ko05340 Primary immunodeficiency 14/323 30/7206 7.60128756141e-12 ko05145 Toxoplasmosis 26/323 126/7206 3.44941746045e-11 ko05162 Measles 25/323 120/7206 6.71665043169e-11 ko05330 Allograft rejection 12/323 24/7206 8.95807168882e-11 ko05150 Staphylococcus aureus infection 14/323 36/7206 1.55275280435e-10 ko05164 Influenza A 29/323 167/7206 2.044905382e-10 ko05168 Herpes simplex infection 30/323 182/7206 3.70154116002e-10 ko04659 Th17 cell differentiation 22/323 106/7206 1.05320189034e-09 ko04630 Jak-STAT signaling pathway 24/323 132/7206 3.06893339094e-09 ko04621 NOD-like receptor signaling pathway 26/323 157/7206 5.27803072929e-09 ko04064 NF-kappa B signaling pathway 20/323 96/7206 5.77375478905e-09 ko05320 Autoimmune thyroid disease 11/323 29/7206 2.07765522804e-08 ko05332 Graft-versus-host disease 9/323 18/7206 2.22505022733e-08 ko04660 T cell receptor signaling pathway 22/323 124/7206 2.27838108882e-08 ko05144 Malaria 13/323 45/7206 4.6204613571e-08 ko04640 Hematopoietic cell lineage 15/323 64/7206 9.27473685735e-08 ko04658 Th1 and Th2 cell differentiation 18/323 96/7206 1.87466178841e-07 ko04612 Antigen processing and presentation 16/323 77/7206 2.07744233519e-07 ko04217 Necroptosis 25/323 178/7206 2.98649533066e-07 ko04672 Intestinal immune network for IgA production 11/323 37/7206 3.71643614115e-07 ko05133 Pertussis 16/323 87/7206 1.19567301382e-06 ko04620 Toll-like receptor signaling pathway 17/323 100/7206 1.74818100741e-06 ko05310 Asthma 7/323 17/7206 4.49353892005e-06 ko04940 Type I diabetes mellitus 9/323 32/7206 7.34636255177e-06 ko04610 Complement and coagulation cascades 14/323 79/7206 8.81182372374e-06 ko04062 Chemokine signaling pathway 24/323 201/7206 9.67609125286e-06 ko04145 Phagosome 19/323 162/7206 0.000106099625073 ko05167 Kaposi's sarcoma-associated herpesvirus infection 21/323 191/7206 0.000118654568934 ko04662 B cell receptor signaling pathway 13/323 88/7206 0.000132739408519 ko05323 Rheumatoid arthritis 13/323 89/7206 0.000149287059569 ko05142 Chagas disease (American trypanosomiasis) 16/323 130/7206 0.000212098370128 ko04611 Platelet activation 18/323 163/7206 0.000343350818232 ko03050 Proteasome 9/323 54/7206 0.00058288395308 ko05161 Hepatitis B 18/323 173/7206 0.00103162794253 ko04666 Fc gamma R-mediated phagocytosis 14/323 122/7206 0.001059522229 ko05132 Salmonella infection 12/323 98/7206 0.00135475303962 ko00120 Primary bile acid biosynthesis 5/323 20/7206 0.00155807326853 ko04514 Cell adhesion molecules (CAMs) 14/323 130/7206 0.00196150883972 ko04664 Fc epsilon RI signaling pathway 10/323 77/7206 0.00215562737141 ko05143 African trypanosomiasis 6/323 32/7206 0.00261014384739 ko04622 RIG-I-like receptor signaling pathway 8/323 62/7206 0.00610499712505 ko04910 Insulin signaling pathway 1/323 172/7206 0.00749228143673 ko00590 Arachidonic acid metabolism 7/323 52/7206 0.00802455146114 ko05416 Viral myocarditis 7/323 55/7206 0.0108601356906 ko05146 Amoebiasis 10/323 99/7206 0.0128857065859 ko05418 Fluid shear stress and atherosclerosis 15/323 173/7206 0.0136507299639 ko04724 Glutamatergic synapse 1/323 152/7206 0.0152752710799 ko04310 Wnt signaling pathway 2/323 181/7206 0.0176429429423 ko04390 Hippo signaling pathway 2/323 188/7206 0.0181925460872 ko05016 Huntington's disease 3/323 215/7206 0.0188573486166 ko04110 Cell cycle 1/323 145/7206 0.0225671595428 ko05206 MicroRNAs in cancer 2/323 177/7206 0.0251856478932 ko05160 Hepatitis C 13/323 153/7206 0.0264572114825 ko00511 Other glycan degradation 4/323 26/7206 0.0271502460441 ko04137 Mitophagy - animal 8/323 82/7206 0.0298817885595 ko04713 Circadian entrainment 1/323 136/7206 0.0324698087515 ko04550 Signaling pathways regulating pluripotency of stem cells 2/323 165/7206 0.0348517819365 ko04360 Axon guidance 4/323 233/7206 0.0351689181911 ko05169 Epstein-Barr virus infection 16/323 206/7206 0.037465552073 ko00051 Fructose and mannose metabolism 5/323 42/7206 0.0383586989369 ko04211 Longevity regulating pathway 1/323 123/7206 0.0449512461737 ko01522 Endocrine resistance 1/323 124/7206 0.0452458296501 ko04670 Leukocyte transendothelial migration 12/323 151/7206 0.0456542554785 ko01200 Carbon metabolism 1/323 128/7206 0.0472375443079