ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	162/965	423/7206	1.19894985564e-40
ko04724	Glutamatergic synapse	82/965	152/7206	2.73348466682e-33
ko05033	Nicotine addiction	45/965	56/7206	7.01069730817e-30
ko04713	Circadian entrainment	70/965	136/7206	7.27652042193e-27
ko05032	Morphine addiction	62/965	110/7206	8.73509230548e-27
ko04727	GABAergic synapse	59/965	110/7206	5.15748105549e-24
ko04728	Dopaminergic synapse	77/965	185/7206	5.33891963284e-22
ko04723	Retrograde endocannabinoid signaling	74/965	175/7206	1.13284248803e-21
ko04725	Cholinergic synapse	67/965	160/7206	1.94824208681e-19
ko04020	Calcium signaling pathway	88/965	265/7206	3.76037938484e-17
ko04024	cAMP signaling pathway	90/965	279/7206	8.55616891949e-17
ko04744	Phototransduction	26/965	36/7206	9.78318084455e-16
ko04921	Oxytocin signaling pathway	72/965	209/7206	2.63602745446e-15
ko04911	Insulin secretion	50/965	117/7206	3.16884929244e-15
ko04742	Taste transduction	33/965	61/7206	4.17333585162e-14
ko04726	Serotonergic synapse	53/965	137/7206	6.7322833688e-14
ko05031	Amphetamine addiction	39/965	91/7206	3.34572509981e-12
ko04721	Synaptic vesicle cycle	36/965	80/7206	3.98655431416e-12
ko04720	Long-term potentiation	40/965	99/7206	1.69050372918e-11
ko04261	Adrenergic signaling in cardiomyocytes	64/965	205/7206	1.86518370274e-11
ko04925	Aldosterone synthesis and secretion	38/965	105/7206	2.35992261265e-09
ko04970	Salivary secretion	35/965	95/7206	5.90817629689e-09
ko03040	Spliceosome	1/965	145/7206	3.79419960357e-08
ko03010	Ribosome	1/965	129/7206	2.89988717233e-07
ko04010	MAPK signaling pathway	76/965	321/7206	3.43290008915e-07
ko05203	Viral carcinogenesis	12/965	277/7206	5.3424094992e-07
ko04971	Gastric acid secretion	32/965	98/7206	6.62253901628e-07
ko04740	Olfactory transduction	28/965	80/7206	6.75776843924e-07
ko04022	cGMP-PKG signaling pathway	56/965	216/7206	6.84429908703e-07
ko04072	Phospholipase D signaling pathway	52/965	197/7206	7.07049421251e-07
ko05030	Cocaine addiction	26/965	73/7206	1.15082896139e-06
ko04730	Long-term depression	27/965	78/7206	1.37002384023e-06
ko05322	Systemic lupus erythematosus	3/965	151/7206	1.38324296502e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	25/965	74/7206	5.54399573498e-06
ko04745	Phototransduction - fly	16/965	38/7206	1.16934304982e-05
ko04972	Pancreatic secretion	32/965	111/7206	1.50550133828e-05
ko04710	Circadian rhythm	17/965	43/7206	1.70883995337e-05
ko04070	Phosphatidylinositol signaling system	32/965	112/7206	1.77623426373e-05
ko05169	Epstein-Barr virus infection	9/965	206/7206	2.5438865404e-05
ko05164	Influenza A	6/965	167/7206	2.68683796024e-05
ko04360	Axon guidance	54/965	233/7206	3.34778712356e-05
ko04540	Gap junction	34/965	128/7206	6.04989300606e-05
ko04750	Inflammatory mediator regulation of TRP channels	33/965	122/7206	6.8822295165e-05
ko04014	Ras signaling pathway	61/965	279/7206	7.01225368241e-05
ko04621	NOD-like receptor signaling pathway	6/965	157/7206	7.65921581606e-05
ko04514	Cell adhesion molecules (CAMs)	34/965	130/7206	7.67441412506e-05
ko04110	Cell cycle	5/965	145/7206	0.000100742155301
ko03013	RNA transport	7/965	166/7206	0.00011747172227
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/965	79/7206	0.000191138961128
ko04260	Cardiac muscle contraction	27/965	98/7206	0.000235340198034
ko04612	Antigen processing and presentation	1/965	77/7206	0.000308131866579
ko05162	Measles	4/965	120/7206	0.000349762345796
ko04915	Estrogen signaling pathway	32/965	131/7206	0.000624159045451
ko04060	Cytokine-cytokine receptor interaction	11/965	191/7206	0.000788046091904
ko05168	Herpes simplex infection	10/965	182/7206	0.000833885378541
ko05414	Dilated cardiomyopathy	28/965	112/7206	0.00106128928573
ko04924	Renin secretion	23/965	86/7206	0.00110371020227
ko04626	Plant-pathogen interaction	8/965	18/7206	0.00126734880612
ko04930	Type II diabetes mellitus	16/965	54/7206	0.00178433398832
ko05231	Choline metabolism in cancer	31/965	134/7206	0.00188338959475
ko03008	Ribosome biogenesis in eukaryotes	2/965	79/7206	0.00223862363459
ko04064	NF-kappa B signaling pathway	4/965	96/7206	0.00396574493585
ko04141	Protein processing in endoplasmic reticulum	12/965	184/7206	0.00409986319141
ko04371	Apelin signaling pathway	37/965	177/7206	0.00493340801865
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/965	59/7206	0.00577107320437
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/965	14/7206	0.0065423616516
ko04912	GnRH signaling pathway	27/965	122/7206	0.00693328663612
ko04610	Complement and coagulation cascades	3/965	79/7206	0.00734958815021
ko05410	Hypertrophic cardiomyopathy (HCM)	23/965	100/7206	0.0073711501505
ko00280	Valine, leucine and isoleucine degradation	1/965	54/7206	0.0077185473292
ko04350	TGF-beta signaling pathway	5/965	103/7206	0.00798264951702
ko05161	Hepatitis B	12/965	173/7206	0.00909708145509
ko04964	Proximal tubule bicarbonate reclamation	9/965	29/7206	0.0109193914194
ko04146	Peroxisome	4/965	89/7206	0.011109503459
ko00330	Arginine and proline metabolism	2/965	61/7206	0.0135527974358
ko04114	Oocyte meiosis	29/965	139/7206	0.0159849887798
ko03420	Nucleotide excision repair	1/965	46/7206	0.0166055025439
ko04916	Melanogenesis	29/965	142/7206	0.0175361395337
ko00562	Inositol phosphate metabolism	20/965	89/7206	0.0176197581103
ko04960	Aldosterone-regulated sodium reabsorption	11/965	41/7206	0.0189939416107
ko04015	Rap1 signaling pathway	51/965	278/7206	0.0190770749919
ko05214	Glioma	18/965	79/7206	0.0192897098416
ko03320	PPAR signaling pathway	3/965	69/7206	0.0206879138721
ko04711	Circadian rhythm - fly	5/965	13/7206	0.0216869422543
ko04918	Thyroid hormone synthesis	19/965	86/7206	0.0244627977306
ko03022	Basal transcription factors	1/965	44/7206	0.0245704135666
ko00071	Fatty acid degradation	1/965	45/7206	0.0251387027651
ko05034	Alcoholism	44/965	238/7206	0.0254164750864
ko04922	Glucagon signaling pathway	26/965	128/7206	0.0255518820317
ko04630	Jak-STAT signaling pathway	9/965	132/7206	0.0271765327533
ko04142	Lysosome	11/965	151/7206	0.028687978359
ko04976	Bile secretion	18/965	80/7206	0.0297772223944
ko04270	Vascular smooth muscle contraction	30/965	154/7206	0.0307653000026
ko04120	Ubiquitin mediated proteolysis	10/965	138/7206	0.0313028380713
ko00240	Pyrimidine metabolism	7/965	110/7206	0.032804659831
ko04722	Neurotrophin signaling pathway	31/965	160/7206	0.0335899533986
ko05145	Toxoplasmosis	9/965	126/7206	0.0346784460157
ko00980	Metabolism of xenobiotics by cytochrome P450	1/965	40/7206	0.0360924148891
ko00140	Steroid hormone biosynthesis	1/965	41/7206	0.0362576422649
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/965	182/7206	0.0362644501199
ko04657	IL-17 signaling pathway	5/965	87/7206	0.0377472745363
ko00680	Methane metabolism	9/965	34/7206	0.0384273540756
ko05140	Leishmaniasis	4/965	75/7206	0.039448255164
ko00590	Arachidonic acid metabolism	2/965	52/7206	0.0398967612332
ko01524	Platinum drug resistance	4/965	76/7206	0.0400292780822
ko04640	Hematopoietic cell lineage	3/965	64/7206	0.040729284731
ko04923	Regulation of lipolysis in adipocytes	17/965	77/7206	0.0410195017117
ko04666	Fc gamma R-mediated phagocytosis	24/965	122/7206	0.0444372004988
ko05205	Proteoglycans in cancer	25/965	271/7206	0.0448468294968
ko04210	Apoptosis	15/965	180/7206	0.0454281643647