ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	177/1072	423/7206	3.45511207266e-44
ko05033	Nicotine addiction	46/1072	56/7206	2.93254525562e-29
ko04724	Glutamatergic synapse	81/1072	152/7206	4.67742632152e-29
ko04721	Synaptic vesicle cycle	50/1072	80/7206	1.49782669872e-22
ko05032	Morphine addiction	60/1072	110/7206	1.81509170828e-22
ko04713	Circadian entrainment	66/1072	136/7206	6.56988040697e-21
ko04727	GABAergic synapse	58/1072	110/7206	8.8364624016e-21
ko04728	Dopaminergic synapse	79/1072	185/7206	1.91300574507e-20
ko04725	Cholinergic synapse	71/1072	160/7206	1.29102004046e-19
ko04723	Retrograde endocannabinoid signaling	70/1072	175/7206	2.11951260295e-16
ko04742	Taste transduction	36/1072	61/7206	1.946225385e-15
ko04024	cAMP signaling pathway	92/1072	279/7206	1.08078890885e-14
ko04726	Serotonergic synapse	56/1072	137/7206	7.86685956635e-14
ko04911	Insulin secretion	49/1072	117/7206	9.85106256078e-13
ko04921	Oxytocin signaling pathway	70/1072	209/7206	7.37652973827e-12
ko05031	Amphetamine addiction	39/1072	91/7206	9.15228615287e-11
ko04020	Calcium signaling pathway	80/1072	265/7206	9.19612201055e-11
ko04720	Long-term potentiation	40/1072	99/7206	4.58590884621e-10
ko04261	Adrenergic signaling in cardiomyocytes	65/1072	205/7206	7.49745581537e-10
ko04360	Axon guidance	70/1072	233/7206	1.76976279066e-09
ko04744	Phototransduction	21/1072	36/7206	2.07588561619e-09
ko03040	Spliceosome	1/1072	145/7206	2.2152171693e-09
ko04060	Cytokine-cytokine receptor interaction	5/1072	191/7206	2.23080300773e-08
ko04740	Olfactory transduction	32/1072	80/7206	3.41191140968e-08
ko05168	Herpes simplex infection	5/1072	182/7206	7.07750498084e-08
ko05030	Cocaine addiction	29/1072	73/7206	1.7896767467e-07
ko04970	Salivary secretion	34/1072	95/7206	5.17203840681e-07
ko05203	Viral carcinogenesis	15/1072	277/7206	6.97136805425e-07
ko03013	RNA transport	5/1072	166/7206	7.0649055855e-07
ko05164	Influenza A	5/1072	167/7206	7.31767319738e-07
ko04971	Gastric acid secretion	33/1072	98/7206	2.39877681285e-06
ko04925	Aldosterone synthesis and secretion	34/1072	105/7206	5.11814278342e-06
ko04120	Ubiquitin mediated proteolysis	4/1072	138/7206	5.18095541001e-06
ko04010	MAPK signaling pathway	78/1072	321/7206	5.74372255827e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1072	74/7206	1.7507793985e-05
ko04966	Collecting duct acid secretion	13/1072	26/7206	2.55014930533e-05
ko04514	Cell adhesion molecules (CAMs)	38/1072	130/7206	2.71242840552e-05
ko04730	Long-term depression	26/1072	78/7206	3.58711992613e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1072	79/7206	4.46266901119e-05
ko04745	Phototransduction - fly	16/1072	38/7206	4.48825332283e-05
ko04621	NOD-like receptor signaling pathway	7/1072	157/7206	5.49317116599e-05
ko04260	Cardiac muscle contraction	30/1072	98/7206	7.35362791967e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1072	79/7206	8.32489499306e-05
ko04141	Protein processing in endoplasmic reticulum	10/1072	184/7206	8.47616183782e-05
ko04540	Gap junction	36/1072	128/7206	8.51835804629e-05
ko04022	cGMP-PKG signaling pathway	54/1072	216/7206	8.60864301956e-05
ko04924	Renin secretion	27/1072	86/7206	9.0348318411e-05
ko05322	Systemic lupus erythematosus	7/1072	151/7206	0.000107658318984
ko05169	Epstein-Barr virus infection	13/1072	206/7206	0.00020495179637
ko05162	Measles	5/1072	120/7206	0.000247264420992
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1072	14/7206	0.000303819631317
ko05205	Proteoglycans in cancer	21/1072	271/7206	0.00045904656837
ko04014	Ras signaling pathway	63/1072	279/7206	0.000549920731189
ko04110	Cell cycle	8/1072	145/7206	0.000564793797032
ko05110	Vibrio cholerae infection	20/1072	63/7206	0.000574868467238
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1072	59/7206	0.000673674600678
ko05140	Leishmaniasis	2/1072	75/7206	0.000907895081434
ko04064	NF-kappa B signaling pathway	4/1072	96/7206	0.0012957358852
ko05161	Hepatitis B	12/1072	173/7206	0.00164345590322
ko04972	Pancreatic secretion	29/1072	111/7206	0.00176466682233
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1072	182/7206	0.00204821875432
ko04612	Antigen processing and presentation	3/1072	77/7206	0.00337406557423
ko00480	Glutathione metabolism	1/1072	55/7206	0.00337561213068
ko04146	Peroxisome	4/1072	89/7206	0.00382203953101
ko04640	Hematopoietic cell lineage	2/1072	64/7206	0.00418662994495
ko05166	HTLV-I infection	27/1072	292/7206	0.00427636013811
ko04750	Inflammatory mediator regulation of TRP channels	30/1072	122/7206	0.00437607352505
ko05414	Dilated cardiomyopathy	28/1072	112/7206	0.00452586867414
ko00590	Arachidonic acid metabolism	1/1072	52/7206	0.0049724758125
ko03018	RNA degradation	4/1072	84/7206	0.00519091474356
ko00330	Arginine and proline metabolism	2/1072	61/7206	0.00608927088743
ko00561	Glycerolipid metabolism	2/1072	63/7206	0.0064608899742
ko04964	Proximal tubule bicarbonate reclamation	10/1072	29/7206	0.00688344774434
ko04214	Apoptosis - fly	3/1072	72/7206	0.00695457604566
ko00260	Glycine, serine and threonine metabolism	1/1072	48/7206	0.00711194421912
ko04915	Estrogen signaling pathway	31/1072	131/7206	0.00865023611805
ko05418	Fluid shear stress and atherosclerosis	14/1072	173/7206	0.00916667816596
ko00240	Pyrimidine metabolism	7/1072	110/7206	0.00963396150545
ko04371	Apelin signaling pathway	39/1072	177/7206	0.00988844034294
ko04070	Phosphatidylinositol signaling system	27/1072	112/7206	0.0102033781581
ko03420	Nucleotide excision repair	1/1072	46/7206	0.0108195783992
ko04626	Plant-pathogen interaction	7/1072	18/7206	0.0112040193085
ko01200	Carbon metabolism	9/1072	128/7206	0.0114648483181
ko05321	Inflammatory bowel disease (IBD)	2/1072	56/7206	0.0129308078387
ko04657	IL-17 signaling pathway	5/1072	87/7206	0.014255996995
ko01524	Platinum drug resistance	4/1072	76/7206	0.0142704065107
ko05034	Alcoholism	49/1072	238/7206	0.0156711441941
ko00983	Drug metabolism - other enzymes	1/1072	42/7206	0.0157069419981
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1072	15/7206	0.0160629690758
ko04976	Bile secretion	20/1072	80/7206	0.0165921373852
ko03022	Basal transcription factors	1/1072	44/7206	0.0166718924495
ko04630	Jak-STAT signaling pathway	10/1072	132/7206	0.0181271235011
ko04668	TNF signaling pathway	9/1072	120/7206	0.019440183707
ko04622	RIG-I-like receptor signaling pathway	3/1072	62/7206	0.0197032173997
ko00310	Lysine degradation	4/1072	73/7206	0.0198130087277
ko04620	Toll-like receptor signaling pathway	7/1072	100/7206	0.0230389978272
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1072	40/7206	0.0235745134681
ko00140	Steroid hormone biosynthesis	1/1072	41/7206	0.0244396693896
ko04072	Phospholipase D signaling pathway	41/1072	197/7206	0.0248654785236
ko00380	Tryptophan metabolism	2/1072	50/7206	0.0267581068059
ko05131	Shigellosis	5/1072	82/7206	0.0271634957958
ko00512	Mucin type O-glycan biosynthesis	9/1072	29/7206	0.0302984194944
ko05145	Toxoplasmosis	10/1072	126/7206	0.0306434478218
ko04722	Neurotrophin signaling pathway	34/1072	160/7206	0.0318775464951
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1072	100/7206	0.0322727251659
ko05133	Pertussis	6/1072	87/7206	0.0332718155509
ko00982	Drug metabolism - cytochrome P450	1/1072	37/7206	0.0347796747577
ko04391	Hippo signaling pathway - fly	21/1072	90/7206	0.0351524305608
ko00630	Glyoxylate and dicarboxylate metabolism	1/1072	38/7206	0.0358276333851
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1072	92/7206	0.0382039169549
ko00270	Cysteine and methionine metabolism	2/1072	47/7206	0.0383355183924
ko00620	Pyruvate metabolism	2/1072	46/7206	0.0383583785784
ko04115	p53 signaling pathway	5/1072	74/7206	0.0482770810101