ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 46/253 423/7206 2.6023476418e-12 ko05033 Nicotine addiction 15/253 56/7206 4.50454259648e-10 ko04724 Glutamatergic synapse 22/253 152/7206 1.23031453198e-08 ko04024 cAMP signaling pathway 29/253 279/7206 1.18285973052e-07 ko04728 Dopaminergic synapse 22/253 185/7206 4.41123280133e-07 ko04723 Retrograde endocannabinoid signaling 21/253 175/7206 7.00978502168e-07 ko04514 Cell adhesion molecules (CAMs) 17/253 130/7206 2.54462934646e-06 ko04721 Synaptic vesicle cycle 13/253 80/7206 3.49437906167e-06 ko04727 GABAergic synapse 15/253 110/7206 5.95023940973e-06 ko05032 Morphine addiction 14/253 110/7206 2.72288990881e-05 ko04010 MAPK signaling pathway 26/253 321/7206 6.13202432871e-05 ko04713 Circadian entrainment 15/253 136/7206 7.72677066251e-05 ko04921 Oxytocin signaling pathway 19/253 209/7206 0.000126793631493 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 10/253 79/7206 0.000405904733908 ko05030 Cocaine addiction 9/253 73/7206 0.000956476123506 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/253 14/7206 0.00112446574806 ko05031 Amphetamine addiction 10/253 91/7206 0.00125236962956 ko04260 Cardiac muscle contraction 10/253 98/7206 0.00220226938228 ko04911 Insulin secretion 11/253 117/7206 0.00259674596855 ko05203 Viral carcinogenesis 2/253 277/7206 0.00660522697128 ko05410 Hypertrophic cardiomyopathy (HCM) 9/253 100/7206 0.00826074717351 ko05014 Amyotrophic lateral sclerosis (ALS) 7/253 74/7206 0.0147106708397 ko04060 Cytokine-cytokine receptor interaction 1/253 191/7206 0.0152016598671 ko05414 Dilated cardiomyopathy 9/253 112/7206 0.016625125081 ko04261 Adrenergic signaling in cardiomyocytes 14/253 205/7206 0.018039695348 ko04742 Taste transduction 6/253 61/7206 0.0195224048593 ko04218 Cellular senescence 1/253 177/7206 0.0218096827925 ko05205 Proteoglycans in cancer 3/253 271/7206 0.0266875223244 ko04725 Cholinergic synapse 11/253 160/7206 0.0279863916839 ko05210 Colorectal cancer 7/253 86/7206 0.0309126867931 ko03013 RNA transport 1/253 166/7206 0.0314377762283 ko04020 Calcium signaling pathway 16/253 265/7206 0.0383130978364 ko04930 Type II diabetes mellitus 5/253 54/7206 0.0400993687919 ko04145 Phagosome 1/253 162/7206 0.0471127117113