ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 27/481 134/7206 1.59506136186e-07 ko04621 NOD-like receptor signaling pathway 29/481 157/7206 3.92470914124e-07 ko04064 NF-kappa B signaling pathway 20/481 96/7206 3.83538935076e-06 ko04060 Cytokine-cytokine receptor interaction 31/481 191/7206 4.43561983838e-06 ko05164 Influenza A 28/481 167/7206 4.61509222387e-06 ko00120 Primary bile acid biosynthesis 8/481 20/7206 2.28923471811e-05 ko04668 TNF signaling pathway 21/481 120/7206 3.74985434397e-05 ko05162 Measles 21/481 120/7206 3.74985434397e-05 ko04217 Necroptosis 27/481 178/7206 4.81325276609e-05 ko05321 Inflammatory bowel disease (IBD) 13/481 56/7206 5.89202705547e-05 ko04650 Natural killer cell mediated cytotoxicity 18/481 97/7206 6.04951924726e-05 ko05340 Primary immunodeficiency 9/481 30/7206 9.84854835438e-05 ko05140 Leishmaniasis 14/481 75/7206 0.000369828410415 ko05145 Toxoplasmosis 19/481 126/7206 0.000789642488491 ko05152 Tuberculosis 25/481 187/7206 0.000849014149763 ko03040 Spliceosome 1/481 145/7206 0.00105019520366 ko00643 Styrene degradation 3/481 4/7206 0.00112384957185 ko00350 Tyrosine metabolism 8/481 33/7206 0.00116607920533 ko03013 RNA transport 2/481 166/7206 0.00140719957278 ko00051 Fructose and mannose metabolism 9/481 42/7206 0.00149679369947 ko04660 T cell receptor signaling pathway 18/481 124/7206 0.00155307089061 ko04658 Th1 and Th2 cell differentiation 15/481 96/7206 0.00160605519452 ko04710 Circadian rhythm 9/481 43/7206 0.00178355893656 ko00590 Arachidonic acid metabolism 10/481 52/7206 0.00198496829322 ko04610 Complement and coagulation cascades 13/481 79/7206 0.00200797763134 ko03010 Ribosome 1/481 129/7206 0.00214613262552 ko04672 Intestinal immune network for IgA production 8/481 37/7206 0.00256161561583 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/481 191/7206 0.00278275974665 ko04137 Mitophagy - animal 13/481 82/7206 0.00282659203302 ko05161 Hepatitis B 22/481 173/7206 0.00301447203295 ko04620 Toll-like receptor signaling pathway 15/481 100/7206 0.0033832755598 ko04068 FoxO signaling pathway 21/481 167/7206 0.00429045215784 ko05160 Hepatitis C 20/481 153/7206 0.00448724107722 ko04659 Th17 cell differentiation 15/481 106/7206 0.00493146293722 ko00140 Steroid hormone biosynthesis 8/481 41/7206 0.00501280746104 ko04623 Cytosolic DNA-sensing pathway 8/481 41/7206 0.00501280746104 ko04210 Apoptosis 22/481 180/7206 0.00569764136579 ko05168 Herpes simplex infection 22/481 182/7206 0.00611354953292 ko05132 Salmonella infection 14/481 98/7206 0.0063472413196 ko00592 alpha-Linolenic acid metabolism 5/481 19/7206 0.0068953878571 ko05133 Pertussis 13/481 87/7206 0.00714601702634 ko04390 Hippo signaling pathway 4/481 188/7206 0.00714716485371 ko04622 RIG-I-like receptor signaling pathway 10/481 62/7206 0.0074203252145 ko04662 B cell receptor signaling pathway 13/481 88/7206 0.00748441975622 ko05150 Staphylococcus aureus infection 7/481 36/7206 0.00866666576762 ko05131 Shigellosis 12/481 82/7206 0.0111441493844 ko04723 Retrograde endocannabinoid signaling 4/481 175/7206 0.0134741892063 ko04611 Platelet activation 19/481 163/7206 0.0160454996074 ko05323 Rheumatoid arthritis 12/481 89/7206 0.0167037111545 ko04922 Glucagon signaling pathway 16/481 128/7206 0.0179283046942 ko05330 Allograft rejection 5/481 24/7206 0.0191382555332 ko03015 mRNA surveillance pathway 1/481 93/7206 0.0204560483775 ko05230 Central carbon metabolism in cancer 11/481 81/7206 0.0216744786006 ko00360 Phenylalanine metabolism 4/481 17/7206 0.0232461804868 ko00950 Isoquinoline alkaloid biosynthesis 3/481 10/7206 0.024914230858 ko04066 HIF-1 signaling pathway 15/481 123/7206 0.0258948828804 ko05144 Malaria 7/481 45/7206 0.0281460385412 ko05332 Graft-versus-host disease 4/481 18/7206 0.028353604923 ko04670 Leukocyte transendothelial migration 17/481 151/7206 0.0307176550501 ko00982 Drug metabolism - cytochrome P450 6/481 37/7206 0.0340553823109 ko04664 Fc epsilon RI signaling pathway 10/481 77/7206 0.0359132870502 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/481 5/7206 0.0388446263038 ko05320 Autoimmune thyroid disease 5/481 29/7206 0.0407163365744 ko05322 Systemic lupus erythematosus 4/481 151/7206 0.0461931405872 ko04657 IL-17 signaling pathway 11/481 87/7206 0.0464956575861 ko04350 TGF-beta signaling pathway 2/481 103/7206 0.0468399418241 ko04630 Jak-STAT signaling pathway 15/481 132/7206 0.0495288353724