ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	186/1116	423/7206	1.16837992226e-47
ko05033	Nicotine addiction	48/1116	56/7206	2.21148835278e-31
ko04724	Glutamatergic synapse	85/1116	152/7206	3.40159042813e-31
ko04727	GABAergic synapse	65/1116	110/7206	6.13390276695e-26
ko05032	Morphine addiction	65/1116	110/7206	6.13390276695e-26
ko04713	Circadian entrainment	69/1116	136/7206	3.34720494295e-22
ko04728	Dopaminergic synapse	83/1116	185/7206	5.73120969535e-22
ko04721	Synaptic vesicle cycle	47/1116	80/7206	6.35280604046e-19
ko04725	Cholinergic synapse	71/1116	160/7206	1.31273371028e-18
ko04723	Retrograde endocannabinoid signaling	75/1116	175/7206	1.59810599474e-18
ko04024	cAMP signaling pathway	99/1116	279/7206	4.01244370899e-17
ko04742	Taste transduction	37/1116	61/7206	8.49644914634e-16
ko04744	Phototransduction	27/1116	36/7206	2.33656643805e-15
ko04726	Serotonergic synapse	58/1116	137/7206	2.67741009647e-14
ko04020	Calcium signaling pathway	90/1116	265/7206	2.90002502026e-14
ko04911	Insulin secretion	50/1116	117/7206	1.09320500822e-12
ko05031	Amphetamine addiction	40/1116	91/7206	7.20029953835e-11
ko04921	Oxytocin signaling pathway	69/1116	209/7206	1.57686837571e-10
ko04261	Adrenergic signaling in cardiomyocytes	68/1116	205/7206	1.9639292133e-10
ko03040	Spliceosome	1/1116	145/7206	8.39672919055e-10
ko04740	Olfactory transduction	34/1116	80/7206	5.65707696483e-09
ko04720	Long-term potentiation	39/1116	99/7206	5.92793614834e-09
ko05030	Cocaine addiction	30/1116	73/7206	1.11642428941e-07
ko05203	Viral carcinogenesis	15/1116	277/7206	1.73933524452e-07
ko04970	Salivary secretion	35/1116	95/7206	3.55681353504e-07
ko05322	Systemic lupus erythematosus	5/1116	151/7206	2.02062365568e-06
ko04925	Aldosterone synthesis and secretion	35/1116	105/7206	4.18524748106e-06
ko04621	NOD-like receptor signaling pathway	6/1116	157/7206	5.38215688324e-06
ko03013	RNA transport	7/1116	166/7206	6.08831409195e-06
ko05164	Influenza A	7/1116	167/7206	6.25231566758e-06
ko04971	Gastric acid secretion	33/1116	98/7206	6.76890856224e-06
ko04745	Phototransduction - fly	17/1116	38/7206	1.692270931e-05
ko04514	Cell adhesion molecules (CAMs)	39/1116	130/7206	2.2976219985e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1116	74/7206	2.70779047988e-05
ko04022	cGMP-PKG signaling pathway	57/1116	216/7206	3.24311394646e-05
ko04966	Collecting duct acid secretion	13/1116	26/7206	3.96370004267e-05
ko05168	Herpes simplex infection	10/1116	182/7206	4.17837567443e-05
ko04060	Cytokine-cytokine receptor interaction	11/1116	191/7206	4.20870289057e-05
ko04072	Phospholipase D signaling pathway	52/1116	197/7206	5.69968685024e-05
ko04070	Phosphatidylinositol signaling system	34/1116	112/7206	5.81626302378e-05
ko04010	MAPK signaling pathway	76/1116	321/7206	9.85039812099e-05
ko04141	Protein processing in endoplasmic reticulum	11/1116	184/7206	0.00011146183743
ko05205	Proteoglycans in cancer	21/1116	271/7206	0.000150463031751
ko05169	Epstein-Barr virus infection	14/1116	206/7206	0.000183711083793
ko04120	Ubiquitin mediated proteolysis	7/1116	138/7206	0.000196185199775
ko04730	Long-term depression	25/1116	78/7206	0.000213222804747
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1116	79/7206	0.000255542808869
ko04110	Cell cycle	8/1116	145/7206	0.000283355692746
ko04972	Pancreatic secretion	32/1116	111/7206	0.00029361175442
ko04260	Cardiac muscle contraction	29/1116	98/7206	0.000350072535601
ko05161	Hepatitis B	11/1116	173/7206	0.000387674364553
ko04612	Antigen processing and presentation	2/1116	77/7206	0.00040056008444
ko03008	Ribosome biogenesis in eukaryotes	2/1116	79/7206	0.000420792534017
ko05162	Measles	6/1116	120/7206	0.00051365425186
ko05140	Leishmaniasis	2/1116	75/7206	0.000593316287649
ko04064	NF-kappa B signaling pathway	4/1116	96/7206	0.000893380934442
ko04924	Renin secretion	25/1116	86/7206	0.00133547343634
ko04610	Complement and coagulation cascades	3/1116	79/7206	0.00157566075563
ko04360	Axon guidance	54/1116	233/7206	0.00166568813385
ko05414	Dilated cardiomyopathy	30/1116	112/7206	0.00214888810159
ko04657	IL-17 signaling pathway	4/1116	87/7206	0.00253267999015
ko04976	Bile secretion	23/1116	80/7206	0.00262513318362
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1116	14/7206	0.00264091310021
ko05110	Vibrio cholerae infection	19/1116	63/7206	0.00267167493969
ko04923	Regulation of lipolysis in adipocytes	22/1116	77/7206	0.00368404935999
ko04540	Gap junction	32/1116	128/7206	0.00436969477927
ko04510	Focal adhesion	22/1116	240/7206	0.00474713986523
ko04750	Inflammatory mediator regulation of TRP channels	31/1116	122/7206	0.00501485696238
ko05166	HTLV-I infection	29/1116	292/7206	0.00628633823513
ko04014	Ras signaling pathway	60/1116	279/7206	0.00671211637646
ko03420	Nucleotide excision repair	1/1116	46/7206	0.00690660192441
ko04915	Estrogen signaling pathway	32/1116	131/7206	0.00693322675017
ko04146	Peroxisome	5/1116	89/7206	0.00728438734114
ko05321	Inflammatory bowel disease (IBD)	2/1116	56/7206	0.00862761954987
ko04964	Proximal tubule bicarbonate reclamation	10/1116	29/7206	0.00915762442213
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1116	182/7206	0.00929284097762
ko05133	Pertussis	5/1116	87/7206	0.0102809090432
ko03022	Basal transcription factors	1/1116	44/7206	0.0104745729921
ko05144	Malaria	1/1116	45/7206	0.0109834549675
ko00071	Fatty acid degradation	1/1116	45/7206	0.0109834549675
ko00562	Inositol phosphate metabolism	23/1116	89/7206	0.011264503246
ko04140	Autophagy - animal	14/1116	164/7206	0.0115963343331
ko00290	Valine, leucine and isoleucine biosynthesis	3/1116	4/7206	0.0131065680451
ko00480	Glutathione metabolism	2/1116	55/7206	0.0131598081196
ko05131	Shigellosis	5/1116	82/7206	0.0137378908912
ko00310	Lysine degradation	4/1116	73/7206	0.0139448164192
ko03018	RNA degradation	5/1116	84/7206	0.01407462743
ko04115	p53 signaling pathway	4/1116	74/7206	0.0141830793976
ko05206	MicroRNAs in cancer	16/1116	177/7206	0.0151416625163
ko00240	Pyrimidine metabolism	8/1116	110/7206	0.0159301239654
ko04710	Circadian rhythm	13/1116	43/7206	0.0171102864429
ko00590	Arachidonic acid metabolism	2/1116	52/7206	0.0187921262701
ko05418	Fluid shear stress and atherosclerosis	16/1116	173/7206	0.0191447649514
ko04622	RIG-I-like receptor signaling pathway	3/1116	62/7206	0.019993650327
ko05231	Choline metabolism in cancer	31/1116	134/7206	0.0211160978068
ko04658	Th1 and Th2 cell differentiation	7/1116	96/7206	0.0225852560131
ko04341	Hedgehog signaling pathway - fly	1/1116	38/7206	0.0229122960675
ko03410	Base excision repair	1/1116	38/7206	0.0229122960675
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1116	100/7206	0.0248967727686
ko05219	Bladder cancer	2/1116	48/7206	0.0262278938988
ko04973	Carbohydrate digestion and absorption	12/1116	42/7206	0.02942655288
ko05215	Prostate cancer	9/1116	111/7206	0.033195986023
ko05145	Toxoplasmosis	11/1116	126/7206	0.034125721347
ko05016	Huntington's disease	22/1116	215/7206	0.0346009748167
ko04210	Apoptosis	18/1116	180/7206	0.0370447179204
ko04640	Hematopoietic cell lineage	4/1116	64/7206	0.0370669597351
ko04810	Regulation of actin cytoskeleton	29/1116	264/7206	0.0376252803602
ko00280	Valine, leucine and isoleucine degradation	3/1116	54/7206	0.0382247136413
ko05416	Viral myocarditis	3/1116	55/7206	0.0382677452263
ko04711	Circadian rhythm - fly	5/1116	13/7206	0.0385287986641
ko05200	Pathways in cancer	60/1116	492/7206	0.0386296163715
ko04630	Jak-STAT signaling pathway	12/1116	132/7206	0.0388649302797
ko05012	Parkinson's disease	15/1116	155/7206	0.0431091979082
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/1116	59/7206	0.0449180304652
ko04217	Necroptosis	18/1116	178/7206	0.0458759213371
ko04626	Plant-pathogen interaction	6/1116	18/7206	0.0478172658216
ko04214	Apoptosis - fly	5/1116	72/7206	0.0478705878909