ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1173	423/7206	5.17786187592e-54
ko04724	Glutamatergic synapse	98/1173	152/7206	1.50571461701e-41
ko04713	Circadian entrainment	83/1173	136/7206	1.07019772994e-32
ko05033	Nicotine addiction	49/1173	56/7206	7.16535826461e-32
ko05032	Morphine addiction	72/1173	110/7206	2.44601781399e-31
ko04727	GABAergic synapse	70/1173	110/7206	2.39079826431e-29
ko04728	Dopaminergic synapse	94/1173	185/7206	2.98336314594e-28
ko04725	Cholinergic synapse	82/1173	160/7206	4.49870907209e-25
ko04723	Retrograde endocannabinoid signaling	82/1173	175/7206	8.75064617084e-22
ko04726	Serotonergic synapse	69/1173	137/7206	1.06151369704e-20
ko04024	cAMP signaling pathway	108/1173	279/7206	3.52705459674e-20
ko04020	Calcium signaling pathway	102/1173	265/7206	6.52217250672e-19
ko04911	Insulin secretion	60/1173	117/7206	1.20377346367e-18
ko04721	Synaptic vesicle cycle	47/1173	80/7206	5.12145190183e-18
ko04921	Oxytocin signaling pathway	85/1173	209/7206	1.09966651776e-17
ko05031	Amphetamine addiction	48/1173	91/7206	8.54593076216e-16
ko04720	Long-term potentiation	50/1173	99/7206	2.1696650667e-15
ko04742	Taste transduction	37/1173	61/7206	4.44380825735e-15
ko04744	Phototransduction	27/1173	36/7206	8.39997220414e-15
ko04261	Adrenergic signaling in cardiomyocytes	76/1173	205/7206	2.97463882321e-13
ko05030	Cocaine addiction	38/1173	73/7206	1.55114217177e-12
ko04970	Salivary secretion	43/1173	95/7206	2.27657985672e-11
ko04925	Aldosterone synthesis and secretion	44/1173	105/7206	3.00685897483e-10
ko04971	Gastric acid secretion	42/1173	98/7206	3.28209014242e-10
ko03040	Spliceosome	1/1173	145/7206	3.28750544378e-10
ko03010	Ribosome	1/1173	129/7206	4.09232945467e-09
ko04070	Phosphatidylinositol signaling system	43/1173	112/7206	1.38049232638e-08
ko04740	Olfactory transduction	33/1173	80/7206	8.04641828939e-08
ko04010	MAPK signaling pathway	89/1173	321/7206	1.0716220793e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1173	74/7206	1.30498518416e-07
ko04360	Axon guidance	68/1173	233/7206	4.91999018824e-07
ko04730	Long-term depression	31/1173	78/7206	5.35812786251e-07
ko05322	Systemic lupus erythematosus	5/1173	151/7206	5.86131389801e-07
ko04022	cGMP-PKG signaling pathway	64/1173	216/7206	7.57316328315e-07
ko04060	Cytokine-cytokine receptor interaction	9/1173	191/7206	1.22451776702e-06
ko04745	Phototransduction - fly	19/1173	38/7206	1.42762967513e-06
ko03013	RNA transport	7/1173	166/7206	1.8914436864e-06
ko04540	Gap junction	42/1173	128/7206	2.91523287272e-06
ko04972	Pancreatic secretion	38/1173	111/7206	3.05340968253e-06
ko05168	Herpes simplex infection	9/1173	182/7206	3.41238968063e-06
ko04072	Phospholipase D signaling pathway	57/1173	197/7206	5.43434041379e-06
ko05203	Viral carcinogenesis	20/1173	277/7206	8.91772402048e-06
ko04924	Renin secretion	30/1173	86/7206	2.20426945274e-05
ko04141	Protein processing in endoplasmic reticulum	11/1173	184/7206	2.83852464331e-05
ko04612	Antigen processing and presentation	1/1173	77/7206	3.13202732963e-05
ko04915	Estrogen signaling pathway	40/1173	131/7206	3.76722266044e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1173	79/7206	8.35414569952e-05
ko04110	Cell cycle	8/1173	145/7206	0.00014213717437
ko04514	Cell adhesion molecules (CAMs)	38/1173	130/7206	0.000170528744177
ko04610	Complement and coagulation cascades	2/1173	79/7206	0.000171640997083
ko03008	Ribosome biogenesis in eukaryotes	2/1173	79/7206	0.000171640997083
ko05414	Dilated cardiomyopathy	34/1173	112/7206	0.000234879148104
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1173	59/7206	0.000261052316806
ko04371	Apelin signaling pathway	48/1173	177/7206	0.000264463131153
ko04912	GnRH signaling pathway	36/1173	122/7206	0.000265539141726
ko04750	Inflammatory mediator regulation of TRP channels	36/1173	122/7206	0.000265539141726
ko05164	Influenza A	11/1173	167/7206	0.000267179619131
ko04260	Cardiac muscle contraction	30/1173	98/7206	0.00044414595568
ko04014	Ras signaling pathway	67/1173	279/7206	0.000657635225922
ko04621	NOD-like receptor signaling pathway	11/1173	157/7206	0.000662298285169
ko04976	Bile secretion	25/1173	80/7206	0.000710133960011
ko05110	Vibrio cholerae infection	21/1173	63/7206	0.000823308268068
ko04923	Regulation of lipolysis in adipocytes	24/1173	77/7206	0.000966610802593
ko05162	Measles	7/1173	120/7206	0.00101653957515
ko05169	Epstein-Barr virus infection	17/1173	206/7206	0.00103948864667
ko00520	Amino sugar and nucleotide sugar metabolism	1/1173	55/7206	0.00135077874691
ko04350	TGF-beta signaling pathway	6/1173	103/7206	0.00187332198129
ko04711	Circadian rhythm - fly	7/1173	13/7206	0.00205961584099
ko00310	Lysine degradation	3/1173	73/7206	0.00217387728791
ko05202	Transcriptional misregulation in cancer	16/1173	188/7206	0.0025146102616
ko04062	Chemokine signaling pathway	49/1173	201/7206	0.00255930412383
ko04916	Melanogenesis	37/1173	142/7206	0.00263063196667
ko04918	Thyroid hormone synthesis	25/1173	86/7206	0.00284205111578
ko05034	Alcoholism	56/1173	238/7206	0.0031095054758
ko04114	Oocyte meiosis	36/1173	139/7206	0.00346093600445
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1173	14/7206	0.00354487808188
ko04146	Peroxisome	5/1173	89/7206	0.00357386858641
ko04964	Proximal tubule bicarbonate reclamation	11/1173	29/7206	0.0040883721798
ko03420	Nucleotide excision repair	1/1173	46/7206	0.0044280186568
ko04626	Plant-pathogen interaction	8/1173	18/7206	0.00454572963722
ko04064	NF-kappa B signaling pathway	6/1173	96/7206	0.00498763903265
ko04922	Glucagon signaling pathway	33/1173	128/7206	0.00520947836985
ko04966	Collecting duct acid secretion	10/1173	26/7206	0.00545008656188
ko05321	Inflammatory bowel disease (IBD)	2/1173	56/7206	0.00571451505817
ko05231	Choline metabolism in cancer	34/1173	134/7206	0.006270329669
ko04115	p53 signaling pathway	4/1173	74/7206	0.00685980405432
ko05140	Leishmaniasis	4/1173	75/7206	0.00688509601946
ko04120	Ubiquitin mediated proteolysis	11/1173	138/7206	0.00693933028825
ko05144	Malaria	1/1173	45/7206	0.00694155441822
ko00071	Fatty acid degradation	1/1173	45/7206	0.00694155441822
ko03018	RNA degradation	5/1173	84/7206	0.00696166851664
ko05016	Huntington's disease	21/1173	215/7206	0.00831945874787
ko00240	Pyrimidine metabolism	8/1173	110/7206	0.0086206314567
ko00562	Inositol phosphate metabolism	24/1173	89/7206	0.00896596378391
ko05161	Hepatitis B	16/1173	173/7206	0.00901169091672
ko04330	Notch signaling pathway	3/1173	62/7206	0.00926918332428
ko04622	RIG-I-like receptor signaling pathway	3/1173	62/7206	0.00926918332428
ko04710	Circadian rhythm	14/1173	43/7206	0.0107480988545
ko04630	Jak-STAT signaling pathway	11/1173	132/7206	0.0118534741203
ko04722	Neurotrophin signaling pathway	38/1173	160/7206	0.0125323757028
ko00590	Arachidonic acid metabolism	2/1173	52/7206	0.0125491431315
ko04015	Rap1 signaling pathway	61/1173	278/7206	0.0126375989937
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1173	100/7206	0.0131873443011
ko04930	Type II diabetes mellitus	16/1173	54/7206	0.0143164458796
ko03410	Base excision repair	1/1173	38/7206	0.0149280573238
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1173	40/7206	0.0156029877293
ko04960	Aldosterone-regulated sodium reabsorption	13/1173	41/7206	0.016717581266
ko00512	Mucin type O-glycan biosynthesis	10/1173	29/7206	0.018664439994
ko04142	Lysosome	14/1173	151/7206	0.0186656997093
ko04270	Vascular smooth muscle contraction	36/1173	154/7206	0.0201215656242
ko05214	Glioma	21/1173	79/7206	0.0201403417233
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1173	15/7206	0.0244620870677
ko04320	Dorso-ventral axis formation	10/1173	31/7206	0.0250968415201
ko04012	ErbB signaling pathway	27/1173	109/7206	0.0251122909729
ko04640	Hematopoietic cell lineage	4/1173	64/7206	0.0262103889559
ko04213	Longevity regulating pathway - multiple species	22/1173	86/7206	0.0263186550743
ko00280	Valine, leucine and isoleucine degradation	3/1173	54/7206	0.0265466121072
ko00480	Glutathione metabolism	3/1173	55/7206	0.0265654480971
ko05205	Proteoglycans in cancer	31/1173	271/7206	0.0288463477565
ko05222	Small cell lung cancer	7/1173	89/7206	0.0294457198015
ko04919	Thyroid hormone signaling pathway	33/1173	143/7206	0.0297597355748
ko04071	Sphingolipid signaling pathway	37/1173	162/7206	0.0305397940114
ko00500	Starch and sucrose metabolism	1/1173	35/7206	0.0348077447278
ko04658	Th1 and Th2 cell differentiation	8/1173	96/7206	0.0356946193382
ko04973	Carbohydrate digestion and absorption	12/1173	42/7206	0.0367487825472
ko04657	IL-17 signaling pathway	7/1173	87/7206	0.0394533090684
ko05166	HTLV-I infection	35/1173	292/7206	0.0429329585192
ko00250	Alanine, aspartate and glutamate metabolism	11/1173	38/7206	0.0450107693937
ko03320	PPAR signaling pathway	5/1173	69/7206	0.0472924020056