ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1196	423/7206	2.92613633922e-53
ko04724	Glutamatergic synapse	91/1196	152/7206	3.90202941238e-34
ko05033	Nicotine addiction	49/1196	56/7206	1.84389306835e-31
ko05032	Morphine addiction	71/1196	110/7206	8.82472615388e-30
ko04713	Circadian entrainment	79/1196	136/7206	1.79125089861e-28
ko04727	GABAergic synapse	68/1196	110/7206	6.62574888256e-27
ko04728	Dopaminergic synapse	88/1196	185/7206	2.82588044951e-23
ko04725	Cholinergic synapse	79/1196	160/7206	2.76360251424e-22
ko04721	Synaptic vesicle cycle	50/1196	80/7206	2.21508872378e-20
ko04723	Retrograde endocannabinoid signaling	80/1196	175/7206	6.79104619278e-20
ko04024	cAMP signaling pathway	104/1196	279/7206	1.76956013784e-17
ko04020	Calcium signaling pathway	99/1196	265/7206	1.01588038633e-16
ko04911	Insulin secretion	57/1196	117/7206	4.70660576417e-16
ko04742	Taste transduction	37/1196	61/7206	8.43591091403e-15
ko04726	Serotonergic synapse	61/1196	137/7206	8.87474224862e-15
ko04921	Oxytocin signaling pathway	79/1196	209/7206	8.11862089755e-14
ko04744	Phototransduction	26/1196	36/7206	1.93214785102e-13
ko05031	Amphetamine addiction	43/1196	91/7206	7.41321643559e-12
ko04720	Long-term potentiation	45/1196	99/7206	1.28971277968e-11
ko04261	Adrenergic signaling in cardiomyocytes	72/1196	205/7206	5.60258472034e-11
ko03040	Spliceosome	1/1196	145/7206	1.20445654179e-10
ko04740	Olfactory transduction	36/1196	80/7206	2.07371133469e-09
ko04970	Salivary secretion	39/1196	95/7206	1.10217856012e-08
ko04360	Axon guidance	73/1196	233/7206	1.59969043619e-08
ko04925	Aldosterone synthesis and secretion	41/1196	105/7206	3.06104245278e-08
ko04971	Gastric acid secretion	38/1196	98/7206	1.2140871112e-07
ko05030	Cocaine addiction	31/1196	73/7206	1.4141345365e-07
ko03013	RNA transport	6/1196	166/7206	2.31406517718e-07
ko04060	Cytokine-cytokine receptor interaction	9/1196	191/7206	5.60267392137e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1196	74/7206	7.54622418457e-07
ko05203	Viral carcinogenesis	19/1196	277/7206	1.4281353175e-06
ko05322	Systemic lupus erythematosus	6/1196	151/7206	2.21194610198e-06
ko04010	MAPK signaling pathway	86/1196	321/7206	2.33423664267e-06
ko04022	cGMP-PKG signaling pathway	63/1196	216/7206	2.64533144741e-06
ko05168	Herpes simplex infection	10/1196	182/7206	7.01846706218e-06
ko04514	Cell adhesion molecules (CAMs)	42/1196	130/7206	7.76429766359e-06
ko04070	Phosphatidylinositol signaling system	38/1196	112/7206	7.77475650181e-06
ko04072	Phospholipase D signaling pathway	57/1196	197/7206	1.02715888301e-05
ko04972	Pancreatic secretion	37/1196	111/7206	1.38470650954e-05
ko04621	NOD-like receptor signaling pathway	8/1196	157/7206	1.74491444504e-05
ko05164	Influenza A	9/1196	167/7206	1.91434485231e-05
ko04141	Protein processing in endoplasmic reticulum	11/1196	184/7206	1.98692492026e-05
ko04540	Gap junction	40/1196	128/7206	3.41090216586e-05
ko04014	Ras signaling pathway	73/1196	279/7206	3.56285458841e-05
ko04730	Long-term depression	28/1196	78/7206	3.81664276834e-05
ko04745	Phototransduction - fly	17/1196	38/7206	4.28548326046e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1196	79/7206	0.000109720893652
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1196	59/7206	0.000122991925355
ko03008	Ribosome biogenesis in eukaryotes	2/1196	79/7206	0.000177845251768
ko04110	Cell cycle	9/1196	145/7206	0.000264742400354
ko04750	Inflammatory mediator regulation of TRP channels	36/1196	122/7206	0.000316228741571
ko04966	Collecting duct acid secretion	12/1196	26/7206	0.000408061483534
ko05110	Vibrio cholerae infection	22/1196	63/7206	0.00044607793243
ko04924	Renin secretion	27/1196	86/7206	0.000637748055004
ko05414	Dilated cardiomyopathy	33/1196	112/7206	0.000726091935065
ko04612	Antigen processing and presentation	3/1196	77/7206	0.00101839405623
ko04710	Circadian rhythm	16/1196	43/7206	0.00130453799356
ko04371	Apelin signaling pathway	46/1196	177/7206	0.00139208871793
ko04260	Cardiac muscle contraction	29/1196	98/7206	0.00140167906209
ko05169	Epstein-Barr virus infection	18/1196	206/7206	0.00159305262464
ko04120	Ubiquitin mediated proteolysis	10/1196	138/7206	0.0016778618589
ko05162	Measles	8/1196	120/7206	0.00181278338206
ko04976	Bile secretion	24/1196	80/7206	0.00234518658189
ko00240	Pyrimidine metabolism	7/1196	110/7206	0.0026376140216
ko04915	Estrogen signaling pathway	35/1196	131/7206	0.0028792304717
ko03320	PPAR signaling pathway	3/1196	69/7206	0.00308251808984
ko04610	Complement and coagulation cascades	4/1196	79/7206	0.00340666961037
ko04657	IL-17 signaling pathway	5/1196	87/7206	0.00351688691615
ko05205	Proteoglycans in cancer	28/1196	271/7206	0.00352524952264
ko04064	NF-kappa B signaling pathway	6/1196	96/7206	0.00354630636713
ko04146	Peroxisome	5/1196	89/7206	0.00363711315867
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1196	14/7206	0.00397245049664
ko04916	Melanogenesis	37/1196	142/7206	0.00408323447809
ko05144	Malaria	1/1196	45/7206	0.00435905669039
ko00071	Fatty acid degradation	1/1196	45/7206	0.00435905669039
ko03420	Nucleotide excision repair	1/1196	46/7206	0.00442293561633
ko05140	Leishmaniasis	4/1196	75/7206	0.00479468565534
ko04626	Plant-pathogen interaction	8/1196	18/7206	0.00514264674764
ko05321	Inflammatory bowel disease (IBD)	2/1196	56/7206	0.00580041763469
ko04912	GnRH signaling pathway	32/1196	122/7206	0.00650839318028
ko00310	Lysine degradation	4/1196	73/7206	0.00675383195908
ko03022	Basal transcription factors	1/1196	44/7206	0.00678575486215
ko05131	Shigellosis	5/1196	82/7206	0.00685105050929
ko00590	Arachidonic acid metabolism	2/1196	52/7206	0.00820969150704
ko04015	Rap1 signaling pathway	63/1196	278/7206	0.00828194329532
ko00330	Arginine and proline metabolism	3/1196	61/7206	0.00913213648512
ko04622	RIG-I-like receptor signaling pathway	3/1196	62/7206	0.00919951635259
ko04658	Th1 and Th2 cell differentiation	7/1196	96/7206	0.012151305226
ko04711	Circadian rhythm - fly	6/1196	13/7206	0.012332117972
ko05133	Pertussis	6/1196	87/7206	0.0128381268953
ko00562	Inositol phosphate metabolism	24/1196	89/7206	0.0137811686835
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1196	100/7206	0.0145660152021
ko00630	Glyoxylate and dicarboxylate metabolism	1/1196	38/7206	0.0147579923474
ko03410	Base excision repair	1/1196	38/7206	0.0147579923474
ko04270	Vascular smooth muscle contraction	37/1196	154/7206	0.0157326475489
ko03018	RNA degradation	6/1196	84/7206	0.01737454975
ko04630	Jak-STAT signaling pathway	12/1196	132/7206	0.0177392950637
ko04115	p53 signaling pathway	5/1196	74/7206	0.0181343311273
ko05231	Choline metabolism in cancer	33/1196	134/7206	0.0182941752878
ko04217	Necroptosis	18/1196	178/7206	0.0184777665941
ko04923	Regulation of lipolysis in adipocytes	21/1196	77/7206	0.0194377527798
ko04964	Proximal tubule bicarbonate reclamation	10/1196	29/7206	0.0198962169793
ko00500	Starch and sucrose metabolism	1/1196	35/7206	0.0220040604908
ko04214	Apoptosis - fly	5/1196	72/7206	0.0249286745377
ko04210	Apoptosis	19/1196	180/7206	0.0254914429139
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1196	182/7206	0.025792827863
ko00620	Pyruvate metabolism	2/1196	46/7206	0.0261339898067
ko00280	Valine, leucine and isoleucine degradation	3/1196	54/7206	0.0263066010017
ko04640	Hematopoietic cell lineage	4/1196	64/7206	0.0264747669778
ko04918	Thyroid hormone synthesis	22/1196	86/7206	0.0287975286324
ko05161	Hepatitis B	18/1196	173/7206	0.0291643106339
ko00640	Propanoate metabolism	1/1196	34/7206	0.0339121201589
ko00983	Drug metabolism - other enzymes	2/1196	42/7206	0.0364265378396
ko04930	Type II diabetes mellitus	15/1196	54/7206	0.0407055300276
ko04620	Toll-like receptor signaling pathway	9/1196	100/7206	0.0414725828336
ko05340	Primary immunodeficiency	1/1196	30/7206	0.0488194656014