ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	191/1109	423/7206	1.20073544654e-51
ko05033	Nicotine addiction	48/1109	56/7206	1.63893238867e-31
ko04724	Glutamatergic synapse	85/1109	152/7206	2.10499100312e-31
ko05032	Morphine addiction	67/1109	110/7206	5.58010633008e-28
ko04713	Circadian entrainment	73/1109	136/7206	1.39569881349e-25
ko04727	GABAergic synapse	64/1109	110/7206	3.48389075341e-25
ko04728	Dopaminergic synapse	85/1109	185/7206	1.56090588541e-23
ko04721	Synaptic vesicle cycle	51/1109	80/7206	7.26380625854e-23
ko04725	Cholinergic synapse	76/1109	160/7206	3.02848605933e-22
ko04723	Retrograde endocannabinoid signaling	77/1109	175/7206	5.44265483652e-20
ko04024	cAMP signaling pathway	101/1109	279/7206	2.33384872175e-18
ko04742	Taste transduction	38/1109	61/7206	7.61372943118e-17
ko04911	Insulin secretion	53/1109	117/7206	9.15634989636e-15
ko04726	Serotonergic synapse	58/1109	137/7206	2.01218317654e-14
ko04921	Oxytocin signaling pathway	76/1109	209/7206	4.99046565841e-14
ko04020	Calcium signaling pathway	89/1109	265/7206	5.52583840995e-14
ko04744	Phototransduction	25/1109	36/7206	4.0806426621e-13
ko04720	Long-term potentiation	44/1109	99/7206	4.02394139654e-12
ko04261	Adrenergic signaling in cardiomyocytes	71/1109	205/7206	4.40207153905e-12
ko05031	Amphetamine addiction	41/1109	91/7206	1.28156897827e-11
ko04740	Olfactory transduction	35/1109	80/7206	1.10207486926e-09
ko03040	Spliceosome	1/1109	145/7206	1.40035162005e-09
ko04970	Salivary secretion	38/1109	95/7206	4.69646454696e-09
ko05030	Cocaine addiction	31/1109	73/7206	2.34879900075e-08
ko04925	Aldosterone synthesis and secretion	38/1109	105/7206	1.3429475183e-07
ko04360	Axon guidance	67/1109	233/7206	1.43578902973e-07
ko04971	Gastric acid secretion	36/1109	98/7206	2.2694871727e-07
ko04060	Cytokine-cytokine receptor interaction	7/1109	191/7206	2.32879554099e-07
ko05203	Viral carcinogenesis	15/1109	277/7206	2.46031182391e-07
ko04010	MAPK signaling pathway	83/1109	321/7206	7.11078828503e-07
ko05168	Herpes simplex infection	7/1109	182/7206	1.05555122492e-06
ko04022	cGMP-PKG signaling pathway	60/1109	216/7206	2.04408734263e-06
ko03013	RNA transport	7/1109	166/7206	6.13743217667e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1109	79/7206	1.0092641102e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1109	74/7206	1.04711727496e-05
ko05322	Systemic lupus erythematosus	6/1109	151/7206	1.08829744168e-05
ko04120	Ubiquitin mediated proteolysis	5/1109	138/7206	1.31628298671e-05
ko04540	Gap junction	39/1109	128/7206	1.70969735073e-05
ko05164	Influenza A	8/1109	167/7206	2.81936020811e-05
ko04966	Collecting duct acid secretion	13/1109	26/7206	3.70046115021e-05
ko04610	Complement and coagulation cascades	1/1109	79/7206	5.24182008731e-05
ko05414	Dilated cardiomyopathy	34/1109	112/7206	5.32611852144e-05
ko04924	Renin secretion	28/1109	86/7206	5.91755333759e-05
ko04514	Cell adhesion molecules (CAMs)	38/1109	130/7206	6.27152238221e-05
ko04915	Estrogen signaling pathway	38/1109	131/7206	6.7859862509e-05
ko04730	Long-term depression	26/1109	78/7206	9.02721406668e-05
ko04972	Pancreatic secretion	33/1109	111/7206	9.91726397483e-05
ko04141	Protein processing in endoplasmic reticulum	11/1109	184/7206	0.000110371621511
ko04260	Cardiac muscle contraction	30/1109	98/7206	0.000112412713104
ko05110	Vibrio cholerae infection	22/1109	63/7206	0.00012450748334
ko04014	Ras signaling pathway	67/1109	279/7206	0.000125252227763
ko04072	Phospholipase D signaling pathway	50/1109	197/7206	0.00027129923177
ko04745	Phototransduction - fly	15/1109	38/7206	0.00027368514342
ko04621	NOD-like receptor signaling pathway	9/1109	157/7206	0.000292969189078
ko04750	Inflammatory mediator regulation of TRP channels	34/1109	122/7206	0.00033970782403
ko03008	Ribosome biogenesis in eukaryotes	2/1109	79/7206	0.000413887925212
ko05162	Measles	6/1109	120/7206	0.00051829273619
ko05169	Epstein-Barr virus infection	15/1109	206/7206	0.000555258251753
ko05140	Leishmaniasis	2/1109	75/7206	0.000595338988252
ko04070	Phosphatidylinositol signaling system	31/1109	112/7206	0.000809504209767
ko04064	NF-kappa B signaling pathway	4/1109	96/7206	0.000885382714008
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1109	59/7206	0.00151491274352
ko05205	Proteoglycans in cancer	24/1109	271/7206	0.00189804493089
ko04371	Apelin signaling pathway	43/1109	177/7206	0.00203874880143
ko00480	Glutathione metabolism	1/1109	55/7206	0.00209927258509
ko04612	Antigen processing and presentation	3/1109	77/7206	0.00228357063112
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1109	182/7206	0.0024026569761
ko04976	Bile secretion	23/1109	80/7206	0.0025434239342
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1109	14/7206	0.00254395042304
ko04146	Peroxisome	4/1109	89/7206	0.00265324461329
ko04640	Hematopoietic cell lineage	2/1109	64/7206	0.00278461075705
ko00590	Arachidonic acid metabolism	1/1109	52/7206	0.0031165842495
ko04626	Plant-pathogen interaction	8/1109	18/7206	0.00317003929956
ko03018	RNA degradation	4/1109	84/7206	0.00359002607336
ko00330	Arginine and proline metabolism	2/1109	61/7206	0.00408365619536
ko04214	Apoptosis - fly	3/1109	72/7206	0.00472543834635
ko04015	Rap1 signaling pathway	60/1109	278/7206	0.00501986975132
ko05161	Hepatitis B	14/1109	173/7206	0.00535039439602
ko04923	Regulation of lipolysis in adipocytes	21/1109	77/7206	0.00642714788421
ko03420	Nucleotide excision repair	1/1109	46/7206	0.00692160968025
ko04110	Cell cycle	11/1109	145/7206	0.00708491350495
ko00240	Pyrimidine metabolism	7/1109	110/7206	0.0071039010544
ko04912	GnRH signaling pathway	30/1109	122/7206	0.0074022604281
ko00260	Glycine, serine and threonine metabolism	1/1109	48/7206	0.00741461742218
ko05321	Inflammatory bowel disease (IBD)	2/1109	56/7206	0.00865142149539
ko03022	Basal transcription factors	1/1109	44/7206	0.0104351786433
ko05144	Malaria	1/1109	45/7206	0.0108507976751
ko00071	Fatty acid degradation	1/1109	45/7206	0.0108507976751
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1109	100/7206	0.0113447971259
ko04062	Chemokine signaling pathway	44/1109	201/7206	0.0128801722665
ko04916	Melanogenesis	33/1109	142/7206	0.013073820627
ko00310	Lysine degradation	4/1109	73/7206	0.0139677500758
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1109	40/7206	0.0154670512978
ko00380	Tryptophan metabolism	2/1109	50/7206	0.018236215723
ko04622	RIG-I-like receptor signaling pathway	3/1109	62/7206	0.0198021827306
ko04658	Th1 and Th2 cell differentiation	7/1109	96/7206	0.0226716718635
ko03410	Base excision repair	1/1109	38/7206	0.0229383222755
ko04657	IL-17 signaling pathway	6/1109	87/7206	0.024369851383
ko05133	Pertussis	6/1109	87/7206	0.024369851383
ko05418	Fluid shear stress and atherosclerosis	16/1109	173/7206	0.0244630678851
ko04217	Necroptosis	17/1109	178/7206	0.0270084710108
ko03320	PPAR signaling pathway	4/1109	69/7206	0.027513374259
ko04350	TGF-beta signaling pathway	8/1109	103/7206	0.0276025611171
ko05034	Alcoholism	49/1109	238/7206	0.0280940372221
ko04668	TNF signaling pathway	10/1109	120/7206	0.0295667053902
ko04114	Oocyte meiosis	31/1109	139/7206	0.0316455213551
ko04964	Proximal tubule bicarbonate reclamation	9/1109	29/7206	0.0335604171551
ko05145	Toxoplasmosis	11/1109	126/7206	0.0341787775882
ko01200	Carbon metabolism	11/1109	128/7206	0.0345944973246
ko04115	p53 signaling pathway	5/1109	74/7206	0.0351910168269
ko00982	Drug metabolism - cytochrome P450	1/1109	37/7206	0.0357214562458
ko01524	Platinum drug resistance	5/1109	76/7206	0.0359178567924
ko04620	Toll-like receptor signaling pathway	8/1109	100/7206	0.0363378953138
ko04930	Type II diabetes mellitus	14/1109	54/7206	0.0374885286037
ko00620	Pyruvate metabolism	2/1109	46/7206	0.0380930610815
ko00270	Cysteine and methionine metabolism	2/1109	47/7206	0.0392524914449
ko04391	Hippo signaling pathway - fly	21/1109	90/7206	0.0399760516791
ko04270	Vascular smooth muscle contraction	33/1109	154/7206	0.0417331434683
ko05131	Shigellosis	6/1109	82/7206	0.0441135692692
ko04722	Neurotrophin signaling pathway	34/1109	160/7206	0.0454290102182
ko04140	Autophagy - animal	16/1109	164/7206	0.0479588207271
ko04918	Thyroid hormone synthesis	20/1109	86/7206	0.0498513953626