ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	196/1062	423/7206	1.29800353576e-58
ko04724	Glutamatergic synapse	89/1062	152/7206	1.55714451958e-36
ko05033	Nicotine addiction	49/1062	56/7206	5.58456663864e-34
ko04713	Circadian entrainment	77/1062	136/7206	2.56296038348e-30
ko05032	Morphine addiction	68/1062	110/7206	3.97348974611e-30
ko04727	GABAergic synapse	66/1062	110/7206	3.62660320429e-28
ko04728	Dopaminergic synapse	86/1062	185/7206	1.35477206047e-25
ko04725	Cholinergic synapse	77/1062	160/7206	3.33957764206e-24
ko04024	cAMP signaling pathway	105/1062	279/7206	4.87738197524e-22
ko04723	Retrograde endocannabinoid signaling	78/1062	175/7206	7.34680941333e-22
ko04721	Synaptic vesicle cycle	49/1062	80/7206	9.52255761105e-22
ko04911	Insulin secretion	57/1062	117/7206	1.65454719458e-18
ko04020	Calcium signaling pathway	95/1062	265/7206	2.75987189574e-18
ko04921	Oxytocin signaling pathway	80/1062	209/7206	1.70594379811e-17
ko04726	Serotonergic synapse	61/1062	137/7206	2.67903474541e-17
ko04744	Phototransduction	27/1062	36/7206	6.50079895544e-16
ko04720	Long-term potentiation	48/1062	99/7206	1.13648201857e-15
ko04742	Taste transduction	35/1062	61/7206	1.19559062388e-14
ko05031	Amphetamine addiction	44/1062	91/7206	2.04923298789e-14
ko04261	Adrenergic signaling in cardiomyocytes	70/1062	205/7206	1.5513600917e-12
ko04970	Salivary secretion	41/1062	95/7206	1.68309824467e-11
ko04971	Gastric acid secretion	40/1062	98/7206	2.37848289104e-10
ko04925	Aldosterone synthesis and secretion	41/1062	105/7206	7.15524690623e-10
ko04740	Olfactory transduction	34/1062	80/7206	1.50823954389e-09
ko03040	Spliceosome	1/1062	145/7206	3.54006877561e-09
ko05030	Cocaine addiction	31/1062	73/7206	8.19812034465e-09
ko04360	Axon guidance	65/1062	233/7206	1.42146043999e-07
ko05203	Viral carcinogenesis	14/1062	277/7206	3.6917326016e-07
ko04010	MAPK signaling pathway	81/1062	321/7206	4.4192816403e-07
ko04022	cGMP-PKG signaling pathway	60/1062	216/7206	4.4875765687e-07
ko05168	Herpes simplex infection	6/1062	182/7206	6.49676820332e-07
ko04060	Cytokine-cytokine receptor interaction	7/1062	191/7206	7.604542122e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1062	74/7206	7.81247511668e-07
ko04120	Ubiquitin mediated proteolysis	3/1062	138/7206	1.19928236648e-06
ko04745	Phototransduction - fly	18/1062	38/7206	1.67105149141e-06
ko04972	Pancreatic secretion	36/1062	111/7206	2.10875008478e-06
ko04730	Long-term depression	28/1062	78/7206	2.66793320795e-06
ko04966	Collecting duct acid secretion	14/1062	26/7206	3.56406057816e-06
ko05110	Vibrio cholerae infection	24/1062	63/7206	4.16035108499e-06
ko04540	Gap junction	39/1062	128/7206	6.15137050045e-06
ko04621	NOD-like receptor signaling pathway	6/1062	157/7206	1.16483767951e-05
ko04072	Phospholipase D signaling pathway	52/1062	197/7206	1.45995294871e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1062	79/7206	1.46963503472e-05
ko03013	RNA transport	7/1062	166/7206	1.90373452261e-05
ko04924	Renin secretion	28/1062	86/7206	2.35033035381e-05
ko04750	Inflammatory mediator regulation of TRP channels	36/1062	122/7206	2.48987204076e-05
ko04141	Protein processing in endoplasmic reticulum	9/1062	184/7206	3.11632819721e-05
ko05322	Systemic lupus erythematosus	6/1062	151/7206	3.55719501559e-05
ko04514	Cell adhesion molecules (CAMs)	37/1062	130/7206	4.66484399896e-05
ko04915	Estrogen signaling pathway	37/1062	131/7206	5.2512139948e-05
ko05164	Influenza A	8/1062	167/7206	5.72062889225e-05
ko04070	Phosphatidylinositol signaling system	33/1062	112/7206	6.59593922614e-05
ko04260	Cardiac muscle contraction	30/1062	98/7206	6.80077369975e-05
ko04014	Ras signaling pathway	65/1062	279/7206	9.76238737803e-05
ko05414	Dilated cardiomyopathy	32/1062	112/7206	0.000131763363502
ko04912	GnRH signaling pathway	34/1062	122/7206	0.000147159101456
ko05169	Epstein-Barr virus infection	13/1062	206/7206	0.000202760487459
ko04110	Cell cycle	7/1062	145/7206	0.000207595447421
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1062	59/7206	0.000255371862868
ko04976	Bile secretion	24/1062	80/7206	0.000389994375954
ko04626	Plant-pathogen interaction	9/1062	18/7206	0.000438278908932
ko04610	Complement and coagulation cascades	2/1062	79/7206	0.000626913378594
ko03008	Ribosome biogenesis in eukaryotes	2/1062	79/7206	0.000626913378594
ko04612	Antigen processing and presentation	2/1062	77/7206	0.000945671097685
ko05162	Measles	6/1062	120/7206	0.00105425725219
ko04371	Apelin signaling pathway	42/1062	177/7206	0.00120649829556
ko04064	NF-kappa B signaling pathway	4/1062	96/7206	0.00130669360287
ko04214	Apoptosis - fly	2/1062	72/7206	0.00209425543397
ko04015	Rap1 signaling pathway	59/1062	278/7206	0.00319572376242
ko00480	Glutathione metabolism	1/1062	55/7206	0.00330896481888
ko04916	Melanogenesis	34/1062	142/7206	0.00374989186007
ko04146	Peroxisome	4/1062	89/7206	0.0037566094929
ko05205	Proteoglycans in cancer	24/1062	271/7206	0.00389061709672
ko05231	Choline metabolism in cancer	32/1062	134/7206	0.00439117019246
ko05140	Leishmaniasis	3/1062	75/7206	0.00486787251874
ko05214	Glioma	21/1062	79/7206	0.00585675293243
ko04330	Notch signaling pathway	2/1062	62/7206	0.00615755265123
ko04964	Proximal tubule bicarbonate reclamation	10/1062	29/7206	0.00643562407592
ko04973	Carbohydrate digestion and absorption	13/1062	42/7206	0.00695688675416
ko00310	Lysine degradation	3/1062	73/7206	0.00704758045086
ko04350	TGF-beta signaling pathway	6/1062	103/7206	0.00734319406508
ko04114	Oocyte meiosis	32/1062	139/7206	0.00769926321316
ko04923	Regulation of lipolysis in adipocytes	20/1062	77/7206	0.00891270493611
ko04071	Sphingolipid signaling pathway	36/1062	162/7206	0.00956855255385
ko00240	Pyrimidine metabolism	7/1062	110/7206	0.00957945190043
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1062	14/7206	0.0105059027593
ko05144	Malaria	1/1062	45/7206	0.0106148725932
ko00071	Fatty acid degradation	1/1062	45/7206	0.0106148725932
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/1062	182/7206	0.0106792564102
ko03420	Nucleotide excision repair	1/1062	46/7206	0.0107369798127
ko04062	Chemokine signaling pathway	43/1062	201/7206	0.011183188709
ko05034	Alcoholism	49/1062	238/7206	0.0119578835342
ko05321	Inflammatory bowel disease (IBD)	2/1062	56/7206	0.0129038159427
ko04217	Necroptosis	15/1062	178/7206	0.0136183000819
ko04657	IL-17 signaling pathway	5/1062	87/7206	0.0141624132343
ko01524	Platinum drug resistance	4/1062	76/7206	0.0143149409352
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1062	100/7206	0.0146508286028
ko03022	Basal transcription factors	1/1062	44/7206	0.0164166048501
ko03018	RNA degradation	5/1062	84/7206	0.0193931353104
ko04918	Thyroid hormone synthesis	21/1062	86/7206	0.0202022007336
ko04270	Vascular smooth muscle contraction	33/1062	154/7206	0.0214719983492
ko05161	Hepatitis B	15/1062	173/7206	0.0220911855578
ko00562	Inositol phosphate metabolism	21/1062	89/7206	0.0233611591915
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1062	40/7206	0.0235180940113
ko04722	Neurotrophin signaling pathway	34/1062	160/7206	0.0236471707328
ko05016	Huntington's disease	20/1062	215/7206	0.0240867498099
ko04210	Apoptosis	16/1062	180/7206	0.0248038196411
ko04668	TNF signaling pathway	9/1062	120/7206	0.0261410375346
ko05131	Shigellosis	5/1062	82/7206	0.0267914092275
ko00330	Arginine and proline metabolism	3/1062	61/7206	0.0279893784228
ko05166	HTLV-I infection	30/1062	292/7206	0.0281414340625
ko04622	RIG-I-like receptor signaling pathway	3/1062	62/7206	0.0286109869432
ko05145	Toxoplasmosis	10/1062	126/7206	0.0302713516571
ko04930	Type II diabetes mellitus	14/1062	54/7206	0.0313102652158
ko00982	Drug metabolism - cytochrome P450	1/1062	37/7206	0.0347595290546
ko04630	Jak-STAT signaling pathway	11/1062	132/7206	0.0347985503981
ko00630	Glyoxylate and dicarboxylate metabolism	1/1062	38/7206	0.0355035149092
ko03410	Base excision repair	1/1062	38/7206	0.0355035149092
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/1062	92/7206	0.0368577097329
ko03320	PPAR signaling pathway	4/1062	69/7206	0.0385337866791
ko00260	Glycine, serine and threonine metabolism	2/1062	48/7206	0.0387842344777
ko05418	Fluid shear stress and atherosclerosis	16/1062	173/7206	0.0388433546718
ko04012	ErbB signaling pathway	24/1062	109/7206	0.0399187143631
ko04658	Th1 and Th2 cell differentiation	7/1062	96/7206	0.0411016740419
ko04960	Aldosterone-regulated sodium reabsorption	11/1062	41/7206	0.0428207691128
ko05010	Alzheimer's disease	40/1062	202/7206	0.0439147082793
ko04115	p53 signaling pathway	5/1062	74/7206	0.0484936403563