ko pathway ratio_in_study ratio_in_pop p_value ko04974 Protein digestion and absorption 30/587 96/7206 4.19573369582e-11 ko05217 Basal cell carcinoma 20/587 68/7206 2.38299267067e-07 ko04260 Cardiac muscle contraction 24/587 98/7206 6.63746228757e-07 ko04512 ECM-receptor interaction 21/587 79/7206 7.79623954958e-07 ko04550 Signaling pathways regulating pluripotency of stem cells 33/587 165/7206 9.1394989978e-07 ko04950 Maturity onset diabetes of the young 12/587 29/7206 1.08938120243e-06 ko05033 Nicotine addiction 17/587 56/7206 1.17327652291e-06 ko05224 Breast cancer 34/587 174/7206 1.41121437249e-06 ko05168 Herpes simplex infection 2/587 182/7206 4.68143684987e-05 ko04978 Mineral absorption 12/587 40/7206 5.08685125973e-05 ko05322 Systemic lupus erythematosus 1/587 151/7206 6.13590343107e-05 ko04080 Neuroactive ligand-receptor interaction 57/587 423/7206 0.000108557285004 ko05016 Huntington's disease 4/587 215/7206 0.000116731037587 ko05203 Viral carcinogenesis 7/587 277/7206 0.000117620320026 ko05164 Influenza A 2/587 167/7206 0.000144680303728 ko04611 Platelet activation 2/587 163/7206 0.000213913730802 ko05200 Pathways in cancer 63/587 492/7206 0.00022307537345 ko04964 Proximal tubule bicarbonate reclamation 9/587 29/7206 0.000336923722276 ko04261 Adrenergic signaling in cardiomyocytes 32/587 205/7206 0.000369209708476 ko04151 PI3K-Akt signaling pathway 52/587 390/7206 0.000380274531484 ko04976 Bile secretion 16/587 80/7206 0.000601183226699 ko04340 Hedgehog signaling pathway 13/587 58/7206 0.000624129261957 ko05162 Measles 1/587 120/7206 0.000635237109796 ko03013 RNA transport 3/587 166/7206 0.00080556638356 ko04360 Axon guidance 34/587 233/7206 0.000859352669691 ko04514 Cell adhesion molecules (CAMs) 22/587 130/7206 0.000916812233869 ko05410 Hypertrophic cardiomyopathy (HCM) 18/587 100/7206 0.00123963849575 ko04120 Ubiquitin mediated proteolysis 2/587 138/7206 0.00135139985783 ko04727 GABAergic synapse 19/587 110/7206 0.00136755359583 ko04728 Dopaminergic synapse 28/587 185/7206 0.00145276778061 ko04621 NOD-like receptor signaling pathway 3/587 157/7206 0.0016445778314 ko00230 Purine metabolism 5/587 194/7206 0.00196899050648 ko04510 Focal adhesion 33/587 240/7206 0.00250594489853 ko05169 Epstein-Barr virus infection 6/587 206/7206 0.00276029641483 ko04140 Autophagy - animal 4/587 164/7206 0.0035528517646 ko04141 Protein processing in endoplasmic reticulum 5/587 184/7206 0.003747520421 ko04062 Chemokine signaling pathway 6/587 201/7206 0.00376132063028 ko00430 Taurine and hypotaurine metabolism 5/587 14/7206 0.00379408798193 ko04390 Hippo signaling pathway 27/587 188/7206 0.00402363985687 ko05202 Transcriptional misregulation in cancer 27/587 188/7206 0.00402363985687 ko04217 Necroptosis 5/587 178/7206 0.0051101946087 ko04721 Synaptic vesicle cycle 14/587 80/7206 0.00583942905163 ko04977 Vitamin digestion and absorption 6/587 22/7206 0.00685709944551 ko04144 Endocytosis 15/587 342/7206 0.00807002486072 ko04310 Wnt signaling pathway 25/587 181/7206 0.00830586264739 ko04010 MAPK signaling pathway 39/587 321/7206 0.0117131570494 ko04660 T cell receptor signaling pathway 3/587 124/7206 0.0125079426765 ko05414 Dilated cardiomyopathy 17/587 112/7206 0.0129763686644 ko03018 RNA degradation 1/587 84/7206 0.0139261267653 ko00350 Tyrosine metabolism 7/587 33/7206 0.0151537938255 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 6/587 26/7206 0.0160190612296 ko04911 Insulin secretion 17/587 117/7206 0.0163315060156 ko04914 Progesterone-mediated oocyte maturation 2/587 104/7206 0.0168505901196 ko04211 Longevity regulating pathway 3/587 123/7206 0.0181223357781 ko04610 Complement and coagulation cascades 1/587 79/7206 0.0202390218337 ko03008 Ribosome biogenesis in eukaryotes 1/587 79/7206 0.0202390218337 ko05152 Tuberculosis 7/587 187/7206 0.0210341109017 ko05161 Hepatitis B 6/587 173/7206 0.022997202571 ko04142 Lysosome 5/587 151/7206 0.0235322952906 ko00564 Glycerophospholipid metabolism 2/587 99/7206 0.0238587168259 ko05012 Parkinson's disease 5/587 155/7206 0.0243307804196 ko05218 Melanoma 13/587 85/7206 0.0253259825791 ko04932 Non-alcoholic fatty liver disease (NAFLD) 7/587 182/7206 0.0277070889096 ko04214 Apoptosis - fly 1/587 72/7206 0.0286081976749 ko00010 Glycolysis / Gluconeogenesis 1/587 74/7206 0.0293646090062 ko05222 Small cell lung cancer 13/587 89/7206 0.0317496954278 ko00190 Oxidative phosphorylation 4/587 127/7206 0.0329178498781 ko01200 Carbon metabolism 4/587 128/7206 0.0329864779785 ko04724 Glutamatergic synapse 20/587 152/7206 0.0339396597571 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 12/587 79/7206 0.034690274901 ko04723 Retrograde endocannabinoid signaling 22/587 175/7206 0.0356309514962 ko05034 Alcoholism 11/587 238/7206 0.0404304527516 ko04060 Cytokine-cytokine receptor interaction 8/587 191/7206 0.0433188792447 ko04066 HIF-1 signaling pathway 4/587 123/7206 0.0447054224853