ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	151/849	423/7206	1.34463845698e-40
ko04724	Glutamatergic synapse	78/849	152/7206	1.11961247773e-33
ko05033	Nicotine addiction	45/849	56/7206	2.32134505022e-32
ko05032	Morphine addiction	57/849	110/7206	4.19058576334e-25
ko04727	GABAergic synapse	56/849	110/7206	3.53373128727e-24
ko04723	Retrograde endocannabinoid signaling	71/849	175/7206	6.87801821963e-23
ko04728	Dopaminergic synapse	71/849	185/7206	3.22637331605e-21
ko04721	Synaptic vesicle cycle	44/849	80/7206	5.43362085553e-21
ko04713	Circadian entrainment	58/849	136/7206	3.85570576643e-20
ko04725	Cholinergic synapse	62/849	160/7206	6.750323476e-19
ko04024	cAMP signaling pathway	82/849	279/7206	7.49882193087e-16
ko04911	Insulin secretion	45/849	117/7206	6.8427868929e-14
ko04742	Taste transduction	31/849	61/7206	6.86815309601e-14
ko04921	Oxytocin signaling pathway	64/849	209/7206	1.10980529483e-13
ko04726	Serotonergic synapse	48/849	137/7206	6.06743267315e-13
ko04261	Adrenergic signaling in cardiomyocytes	60/849	205/7206	5.85596583258e-12
ko04020	Calcium signaling pathway	69/849	265/7206	7.42723263582e-11
ko04720	Long-term potentiation	36/849	99/7206	1.49788800076e-10
ko05031	Amphetamine addiction	34/849	91/7206	2.09001337822e-10
ko04744	Phototransduction	19/849	36/7206	2.25459459878e-09
ko04925	Aldosterone synthesis and secretion	32/849	105/7206	2.02265985804e-07
ko03040	Spliceosome	1/849	145/7206	3.49072081776e-07
ko05203	Viral carcinogenesis	9/849	277/7206	5.02910912179e-07
ko04970	Salivary secretion	29/849	95/7206	7.2524519388e-07
ko04971	Gastric acid secretion	29/849	98/7206	1.48388356333e-06
ko05030	Cocaine addiction	24/849	73/7206	1.50175885469e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	24/849	74/7206	1.97895708684e-06
ko04010	MAPK signaling pathway	66/849	321/7206	4.8250227267e-06
ko04514	Cell adhesion molecules (CAMs)	34/849	130/7206	5.6083514221e-06
ko04060	Cytokine-cytokine receptor interaction	5/849	191/7206	6.29117219903e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/849	79/7206	7.17711070644e-06
ko04966	Collecting duct acid secretion	12/849	26/7206	1.32352157018e-05
ko05164	Influenza A	4/849	167/7206	1.49137719542e-05
ko04260	Cardiac muscle contraction	27/849	98/7206	1.905737803e-05
ko05168	Herpes simplex infection	5/849	182/7206	1.92617079848e-05
ko04022	cGMP-PKG signaling pathway	47/849	216/7206	2.25027806967e-05
ko04072	Phospholipase D signaling pathway	43/849	197/7206	4.43889442501e-05
ko04745	Phototransduction - fly	14/849	38/7206	5.65613746023e-05
ko04730	Long-term depression	22/849	78/7206	6.14166381338e-05
ko04972	Pancreatic secretion	28/849	111/7206	7.31742369119e-05
ko04120	Ubiquitin mediated proteolysis	3/849	138/7206	7.68483059433e-05
ko05322	Systemic lupus erythematosus	4/849	151/7206	9.54468766001e-05
ko05169	Epstein-Barr virus infection	8/849	206/7206	0.000101314934685
ko05110	Vibrio cholerae infection	18/849	63/7206	0.000236067259301
ko04915	Estrogen signaling pathway	30/849	131/7206	0.000290417548653
ko05162	Measles	3/849	120/7206	0.000473958014356
ko05205	Proteoglycans in cancer	15/849	271/7206	0.000516381568889
ko04626	Plant-pathogen interaction	8/849	18/7206	0.000530928881891
ko04630	Jak-STAT signaling pathway	4/849	132/7206	0.000546538478502
ko05414	Dilated cardiomyopathy	26/849	112/7206	0.000548720128609
ko04621	NOD-like receptor signaling pathway	6/849	157/7206	0.000648688674542
ko03013	RNA transport	7/849	166/7206	0.000925598654282
ko04740	Olfactory transduction	20/849	80/7206	0.00124050393828
ko05166	HTLV-I infection	18/849	292/7206	0.00153320493521
ko04070	Phosphatidylinositol signaling system	25/849	112/7206	0.00157032568974
ko04141	Protein processing in endoplasmic reticulum	9/849	184/7206	0.00167522935419
ko05161	Hepatitis B	8/849	173/7206	0.00173074653819
ko04540	Gap junction	27/849	128/7206	0.00212653943333
ko04110	Cell cycle	6/849	145/7206	0.00243804000573
ko04750	Inflammatory mediator regulation of TRP channels	26/849	122/7206	0.00252799055648
ko04360	Axon guidance	43/849	233/7206	0.00254997896276
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/849	14/7206	0.00341770537224
ko04640	Hematopoietic cell lineage	1/849	64/7206	0.00550015547233
ko04064	NF-kappa B signaling pathway	3/849	96/7206	0.00584363948301
ko04924	Renin secretion	19/849	86/7206	0.00615274096988
ko01524	Platinum drug resistance	2/849	76/7206	0.00696967668751
ko04612	Antigen processing and presentation	2/849	77/7206	0.0069726706108
ko05410	Hypertrophic cardiomyopathy (HCM)	21/849	100/7206	0.00725163715184
ko03008	Ribosome biogenesis in eukaryotes	2/849	79/7206	0.00727471901489
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/849	59/7206	0.00794603687596
ko04140	Autophagy - animal	9/849	164/7206	0.00953305260945
ko04912	GnRH signaling pathway	24/849	122/7206	0.0101902861771
ko05140	Leishmaniasis	2/849	75/7206	0.0102985837006
ko05215	Prostate cancer	5/849	111/7206	0.0114907879778
ko05120	Epithelial cell signaling in Helicobacter pylori infection	19/849	92/7206	0.013423522638
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/849	182/7206	0.0138383141003
ko04214	Apoptosis - fly	2/849	72/7206	0.0149938452061
ko00240	Pyrimidine metabolism	5/849	110/7206	0.0159479030064
ko04114	Oocyte meiosis	26/849	139/7206	0.0159545645241
ko04964	Proximal tubule bicarbonate reclamation	8/849	29/7206	0.0160555047847
ko04014	Ras signaling pathway	46/849	279/7206	0.0174592212643
ko00480	Glutathione metabolism	1/849	55/7206	0.018235405869
ko04510	Focal adhesion	17/849	240/7206	0.0190134173694
ko04550	Signaling pathways regulating pluripotency of stem cells	10/849	165/7206	0.0196037143286
ko04371	Apelin signaling pathway	31/849	177/7206	0.0239938769829
ko04330	Notch signaling pathway	2/849	62/7206	0.029290324597
ko00561	Glycerolipid metabolism	2/849	63/7206	0.0293704473983
ko04146	Peroxisome	4/849	89/7206	0.0301591753195
ko05222	Small cell lung cancer	4/849	89/7206	0.0301591753195
ko04931	Insulin resistance	8/849	137/7206	0.0310413506597
ko05034	Alcoholism	39/849	238/7206	0.0312117746525
ko04218	Cellular senescence	12/849	177/7206	0.0335784384968
ko04976	Bile secretion	16/849	80/7206	0.0338853160896
ko04210	Apoptosis	12/849	180/7206	0.0340531888993
ko04071	Sphingolipid signaling pathway	28/849	162/7206	0.0352972627532
ko03420	Nucleotide excision repair	1/849	46/7206	0.0377263158372
ko00260	Glycine, serine and threonine metabolism	1/849	48/7206	0.0391276010415
ko05219	Bladder cancer	1/849	48/7206	0.0391276010415
ko03018	RNA degradation	4/849	84/7206	0.0409600315689
ko05220	Chronic myeloid leukemia	4/849	85/7206	0.041065737397
ko04962	Vasopressin-regulated water reabsorption	12/849	58/7206	0.0412327428751
ko00310	Lysine degradation	3/849	73/7206	0.042617168223
ko00330	Arginine and proline metabolism	2/849	61/7206	0.0428321012617
ko04668	TNF signaling pathway	7/849	120/7206	0.0442487467012
ko05323	Rheumatoid arthritis	17/849	89/7206	0.0446840131012
ko05010	Alzheimer's disease	33/849	202/7206	0.0461983304182
ko01521	EGFR tyrosine kinase inhibitor resistance	6/849	106/7206	0.0480142947697