ko pathway ratio_in_study ratio_in_pop p_value ko04720 Long-term potentiation 18/238 99/7206 2.66950620604e-09 ko05031 Amphetamine addiction 17/238 91/7206 4.86936929378e-09 ko04745 Phototransduction - fly 11/238 38/7206 2.21725585532e-08 ko04626 Plant-pathogen interaction 8/238 18/7206 4.14162535555e-08 ko04713 Circadian entrainment 19/238 136/7206 8.53602638448e-08 ko04922 Glucagon signaling pathway 17/238 128/7206 8.73977184177e-07 ko04911 Insulin secretion 16/238 117/7206 1.24399598449e-06 ko04921 Oxytocin signaling pathway 22/238 209/7206 1.27284780883e-06 ko04925 Aldosterone synthesis and secretion 15/238 105/7206 1.53579585149e-06 ko04728 Dopaminergic synapse 19/238 185/7206 9.97337517309e-06 ko04740 Olfactory transduction 12/238 80/7206 1.04956871667e-05 ko04371 Apelin signaling pathway 17/238 177/7206 6.98824759626e-05 ko04070 Phosphatidylinositol signaling system 13/238 112/7206 7.44805234926e-05 ko04724 Glutamatergic synapse 15/238 152/7206 0.000138282800687 ko05152 Tuberculosis 17/238 187/7206 0.000138363759758 ko04114 Oocyte meiosis 14/238 139/7206 0.000186071978147 ko04725 Cholinergic synapse 15/238 160/7206 0.000244769409488 ko05214 Glioma 10/238 79/7206 0.000248624426222 ko04727 GABAergic synapse 12/238 110/7206 0.000255037127498 ko04721 Synaptic vesicle cycle 10/238 80/7206 0.000276050848441 ko04971 Gastric acid secretion 11/238 98/7206 0.000358935868176 ko04261 Adrenergic signaling in cardiomyocytes 17/238 205/7206 0.000415392429894 ko04020 Calcium signaling pathway 20/238 265/7206 0.000567036513839 ko00010 Glycolysis / Gluconeogenesis 9/238 74/7206 0.00068291277399 ko00680 Methane metabolism 6/238 34/7206 0.000753471195612 ko05010 Alzheimer's disease 16/238 202/7206 0.00100788362877 ko04138 Autophagy - yeast 9/238 81/7206 0.00131953903715 ko04966 Collecting duct acid secretion 5/238 26/7206 0.00140357462783 ko04912 GnRH signaling pathway 11/238 122/7206 0.00224384849401 ko00051 Fructose and mannose metabolism 6/238 42/7206 0.00235784058449 ko04722 Neurotrophin signaling pathway 13/238 160/7206 0.00236389517235 ko05034 Alcoholism 17/238 238/7206 0.00248516389728 ko04024 cAMP signaling pathway 19/238 279/7206 0.00289285399461 ko00190 Oxidative phosphorylation 11/238 127/7206 0.00307873761442 ko04016 MAPK signaling pathway - plant 4/238 20/7206 0.00370348312684 ko05110 Vibrio cholerae infection 7/238 63/7206 0.00449295728321 ko04137 Mitophagy - animal 8/238 82/7206 0.0054581703072 ko04726 Serotonergic synapse 11/238 137/7206 0.00549331549855 ko04744 Phototransduction 5/238 36/7206 0.00615206371517 ko01230 Biosynthesis of amino acids 8/238 85/7206 0.00677387193478 ko04750 Inflammatory mediator regulation of TRP channels 10/238 122/7206 0.00691178771239 ko04916 Melanogenesis 11/238 142/7206 0.00716306335682 ko04924 Renin secretion 8/238 86/7206 0.00726180405459 ko04723 Retrograde endocannabinoid signaling 13/238 175/7206 0.00772285978662 ko00562 Inositol phosphate metabolism 8/238 89/7206 0.00888541815838 ko01200 Carbon metabolism 10/238 128/7206 0.009585814843 ko05033 Nicotine addiction 6/238 56/7206 0.00995180602275 ko05032 Morphine addiction 9/238 110/7206 0.0102975194368 ko05014 Amyotrophic lateral sclerosis (ALS) 7/238 74/7206 0.0107711130811 ko05167 Kaposi's sarcoma-associated herpesvirus infection 13/238 191/7206 0.0119379773162 ko04068 FoxO signaling pathway 12/238 167/7206 0.0125199379108 ko04970 Salivary secretion 8/238 95/7206 0.0129274363841 ko04014 Ras signaling pathway 17/238 279/7206 0.0149200721364 ko04022 cGMP-PKG signaling pathway 14/238 216/7206 0.0174682666371 ko04136 Autophagy - other 4/238 31/7206 0.0181213876709 ko04066 HIF-1 signaling pathway 9/238 123/7206 0.0202241112166 ko04012 ErbB signaling pathway 8/238 109/7206 0.0273526612633 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/238 92/7206 0.0319579808318 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/238 1/7206 0.0330280321955 ko00750 Vitamin B6 metabolism 2/238 9/7206 0.0335522422754 ko00072 Synthesis and degradation of ketone bodies 2/238 10/7206 0.0410418291284 ko04260 Cardiac muscle contraction 7/238 98/7206 0.0428409515972