ko pathway ratio_in_study ratio_in_pop p_value ko03440 Homologous recombination 23/324 41/7206 4.66220985105e-21 ko04110 Cell cycle 39/324 145/7206 1.50164572218e-20 ko04111 Cell cycle - yeast 31/324 90/7206 5.01648844345e-20 ko03460 Fanconi anemia pathway 24/324 51/7206 1.53629463251e-19 ko03040 Spliceosome 34/324 145/7206 4.99154163327e-16 ko04113 Meiosis - yeast 22/324 70/7206 1.37121608465e-13 ko03030 DNA replication 16/324 38/7206 1.75144052386e-12 ko03013 RNA transport 29/324 166/7206 1.89645293485e-10 ko03420 Nucleotide excision repair 14/324 46/7206 6.78637935732e-09 ko03430 Mismatch repair 10/324 22/7206 1.17568384372e-08 ko03022 Basal transcription factors 13/324 44/7206 3.55047088056e-08 ko03410 Base excision repair 12/324 38/7206 5.25597207567e-08 ko04914 Progesterone-mediated oocyte maturation 19/324 104/7206 1.37625022453e-07 ko04114 Oocyte meiosis 21/324 139/7206 8.49914453348e-07 ko00240 Pyrimidine metabolism 18/324 110/7206 1.60999133185e-06 ko04144 Endocytosis 1/324 342/7206 3.0649913401e-06 ko05166 HTLV-I infection 30/324 292/7206 1.79402961758e-05 ko03018 RNA degradation 14/324 84/7206 1.89912080493e-05 ko04120 Ubiquitin mediated proteolysis 18/324 138/7206 4.12655400527e-05 ko03008 Ribosome biogenesis in eukaryotes 12/324 79/7206 0.00018850857654 ko04510 Focal adhesion 1/324 240/7206 0.000351410685586 ko04024 cAMP signaling pathway 2/324 279/7206 0.000530263638017 ko04022 cGMP-PKG signaling pathway 1/324 216/7206 0.00114909062495 ko04218 Cellular senescence 18/324 177/7206 0.00122149517677 ko04151 PI3K-Akt signaling pathway 6/324 390/7206 0.0015877013593 ko04014 Ras signaling pathway 3/324 279/7206 0.00180444799806 ko04810 Regulation of actin cytoskeleton 3/324 264/7206 0.00359801960047 ko03450 Non-homologous end-joining 4/324 15/7206 0.00369155235896 ko04115 p53 signaling pathway 9/324 74/7206 0.00563933633022 ko03015 mRNA surveillance pathway 10/324 93/7206 0.00863143026087 ko04261 Adrenergic signaling in cardiomyocytes 2/324 205/7206 0.00906427218844 ko05205 Proteoglycans in cancer 4/324 271/7206 0.0102691883681 ko04621 NOD-like receptor signaling pathway 1/324 157/7206 0.0103066521628 ko05203 Viral carcinogenesis 22/324 277/7206 0.0107855344888 ko04530 Tight junction 3/324 228/7206 0.013724517566 ko04724 Glutamatergic synapse 1/324 152/7206 0.0153487770169 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/324 182/7206 0.0176375314973 ko04728 Dopaminergic synapse 2/324 185/7206 0.0178354258177 ko03060 Protein export 4/324 23/7206 0.0180436548641 ko04390 Hippo signaling pathway 2/324 188/7206 0.0182995649844 ko04931 Insulin resistance 1/324 137/7206 0.0215051467533 ko04723 Retrograde endocannabinoid signaling 2/324 175/7206 0.0249710642965 ko04015 Rap1 signaling pathway 5/324 278/7206 0.0253790922614 ko04921 Oxytocin signaling pathway 3/324 209/7206 0.0261620063204 ko01200 Carbon metabolism 1/324 128/7206 0.0309936229962 ko04514 Cell adhesion molecules (CAMs) 1/324 130/7206 0.03104259758 ko04630 Jak-STAT signaling pathway 1/324 132/7206 0.0313345151325 ko04713 Circadian entrainment 1/324 136/7206 0.0326455416667 ko04611 Platelet activation 2/324 163/7206 0.0347751121044 ko04360 Axon guidance 4/324 233/7206 0.0352376952658 ko04072 Phospholipase D signaling pathway 3/324 197/7206 0.0357346089314 ko04010 MAPK signaling pathway 7/324 321/7206 0.0380905011118 ko04750 Inflammatory mediator regulation of TRP channels 1/324 122/7206 0.0447995134553 ko04666 Fc gamma R-mediated phagocytosis 1/324 122/7206 0.0447995134553 ko04066 HIF-1 signaling pathway 1/324 123/7206 0.0450440975382 ko00190 Oxidative phosphorylation 1/324 127/7206 0.0468422636556 ko05012 Parkinson's disease 2/324 155/7206 0.0486482400412 ko05152 Tuberculosis 3/324 187/7206 0.0488959044981 ko05202 Transcriptional misregulation in cancer 3/324 188/7206 0.0489166143243