ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 43/418 157/7206 1.51031168923e-18 ko04060 Cytokine-cytokine receptor interaction 46/418 191/7206 2.36318072028e-17 ko04380 Osteoclast differentiation 35/418 134/7206 1.36218094122e-14 ko05164 Influenza A 37/418 167/7206 6.10074735919e-13 ko05340 Primary immunodeficiency 15/418 30/7206 1.53991995404e-11 ko04064 NF-kappa B signaling pathway 26/418 96/7206 1.55952007388e-11 ko04650 Natural killer cell mediated cytotoxicity 26/418 97/7206 2.01823951618e-11 ko05162 Measles 29/418 120/7206 2.22980546631e-11 ko04620 Toll-like receptor signaling pathway 26/418 100/7206 4.27905142953e-11 ko04217 Necroptosis 35/418 178/7206 9.63991828763e-11 ko05140 Leishmaniasis 21/418 75/7206 7.51515207741e-10 ko05168 Herpes simplex infection 34/418 182/7206 7.61192724475e-10 ko05152 Tuberculosis 33/418 187/7206 6.18046419663e-09 ko05321 Inflammatory bowel disease (IBD) 17/418 56/7206 8.3126150936e-09 ko05167 Kaposi's sarcoma-associated herpesvirus infection 33/418 191/7206 1.07003743519e-08 ko04660 T cell receptor signaling pathway 25/418 124/7206 2.98992938057e-08 ko05145 Toxoplasmosis 25/418 126/7206 4.18330551171e-08 ko05320 Autoimmune thyroid disease 11/418 29/7206 2.93614889677e-07 ko05330 Allograft rejection 10/418 24/7206 3.64695399277e-07 ko05150 Staphylococcus aureus infection 12/418 36/7206 4.34345021546e-07 ko04659 Th17 cell differentiation 21/418 106/7206 5.30798037949e-07 ko04612 Antigen processing and presentation 17/418 77/7206 1.34066142121e-06 ko04622 RIG-I-like receptor signaling pathway 15/418 62/7206 1.65249669954e-06 ko05133 Pertussis 18/418 87/7206 1.79638921738e-06 ko04658 Th1 and Th2 cell differentiation 19/418 96/7206 1.88630127873e-06 ko05161 Hepatitis B 27/418 173/7206 1.95085066593e-06 ko05323 Rheumatoid arthritis 18/418 89/7206 2.54137235394e-06 ko05332 Graft-versus-host disease 8/418 18/7206 3.13520521044e-06 ko04630 Jak-STAT signaling pathway 22/418 132/7206 5.95134795426e-06 ko04662 B cell receptor signaling pathway 17/418 88/7206 9.26907669728e-06 ko04623 Cytosolic DNA-sensing pathway 11/418 41/7206 1.42169462945e-05 ko04668 TNF signaling pathway 20/418 120/7206 1.58010728825e-05 ko04062 Chemokine signaling pathway 28/418 201/7206 1.71436889698e-05 ko04672 Intestinal immune network for IgA production 10/418 37/7206 3.27227411807e-05 ko05144 Malaria 11/418 45/7206 3.69911017179e-05 ko04610 Complement and coagulation cascades 15/418 79/7206 3.85135648028e-05 ko04210 Apoptosis 24/418 180/7206 0.0001217961781 ko05142 Chagas disease (American trypanosomiasis) 19/418 130/7206 0.000161999653456 ko04145 Phagosome 22/418 162/7206 0.000208270756364 ko05310 Asthma 6/418 17/7206 0.000262836438753 ko04940 Type I diabetes mellitus 8/418 32/7206 0.000366796581701 ko05160 Hepatitis C 20/418 153/7206 0.0005988023373 ko00120 Primary bile acid biosynthesis 6/418 20/7206 0.00070922537191 ko04640 Hematopoietic cell lineage 11/418 64/7206 0.000999810915964 ko05132 Salmonella infection 14/418 98/7206 0.0014519043499 ko04390 Hippo signaling pathway 2/418 188/7206 0.00217303795719 ko04666 Fc gamma R-mediated phagocytosis 16/418 122/7206 0.00236915896322 ko04080 Neuroactive ligand-receptor interaction 11/418 423/7206 0.00246984434732 ko05034 Alcoholism 4/418 238/7206 0.0027562311065 ko04310 Wnt signaling pathway 2/418 181/7206 0.00310609268898 ko04916 Melanogenesis 1/418 142/7206 0.00323729484584 ko03040 Spliceosome 1/418 145/7206 0.00332193717368 ko05134 Legionellosis 11/418 74/7206 0.00333683116363 ko03050 Proteasome 9/418 54/7206 0.00352358633422 ko04664 Fc epsilon RI signaling pathway 11/418 77/7206 0.00456422133877 ko05418 Fluid shear stress and atherosclerosis 18/418 173/7206 0.0132313498413 ko04723 Retrograde endocannabinoid signaling 3/418 175/7206 0.0133226326179 ko04911 Insulin secretion 1/418 117/7206 0.0147362898607 ko04611 Platelet activation 17/418 163/7206 0.0165412555974 ko04657 IL-17 signaling pathway 11/418 87/7206 0.0167467136278 ko05032 Morphine addiction 1/418 110/7206 0.0213042772223 ko04972 Pancreatic secretion 1/418 111/7206 0.0215814450871 ko00592 alpha-Linolenic acid metabolism 4/418 19/7206 0.0215826939924 ko04514 Cell adhesion molecules (CAMs) 14/418 130/7206 0.0216739504908 ko05169 Epstein-Barr virus infection 20/418 206/7206 0.0220264934939 ko04728 Dopaminergic synapse 4/418 185/7206 0.0254731838147 ko04550 Signaling pathways regulating pluripotency of stem cells 3/418 165/7206 0.0263061329424 ko05131 Shigellosis 10/418 82/7206 0.0268121138799 ko04137 Mitophagy - animal 10/418 82/7206 0.0268121138799 ko05166 HTLV-I infection 26/418 292/7206 0.0286484361356 ko00590 Arachidonic acid metabolism 7/418 52/7206 0.0293466807997 ko04360 Axon guidance 6/418 233/7206 0.0313079952335 ko00051 Fructose and mannose metabolism 6/418 42/7206 0.0327334439221 ko01200 Carbon metabolism 2/418 128/7206 0.0341527807222 ko05416 Viral myocarditis 7/418 55/7206 0.0384256173148 ko04020 Calcium signaling pathway 8/418 265/7206 0.0446803884741 ko05146 Amoebiasis 11/418 99/7206 0.046258564316