ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 37/516 191/7206 1.62641191081e-08 ko00120 Primary bile acid biosynthesis 9/516 20/7206 3.79782784674e-06 ko04610 Complement and coagulation cascades 16/516 79/7206 0.000118980292459 ko04621 NOD-like receptor signaling pathway 25/516 157/7206 0.000124307310858 ko04710 Circadian rhythm 11/516 43/7206 0.00015951681106 ko04672 Intestinal immune network for IgA production 10/516 37/7206 0.000193500924125 ko04380 Osteoclast differentiation 22/516 134/7206 0.00023217050811 ko04064 NF-kappa B signaling pathway 17/516 96/7206 0.000404350274656 ko03040 Spliceosome 1/516 145/7206 0.000462937085929 ko05321 Inflammatory bowel disease (IBD) 12/516 56/7206 0.000485946652376 ko05152 Tuberculosis 26/516 187/7206 0.00127448266738 ko05323 Rheumatoid arthritis 15/516 89/7206 0.00147632980823 ko03010 Ribosome 1/516 129/7206 0.00148459567087 ko00592 alpha-Linolenic acid metabolism 6/516 19/7206 0.00158723791641 ko04640 Hematopoietic cell lineage 12/516 64/7206 0.00169129599113 ko04650 Natural killer cell mediated cytotoxicity 16/516 97/7206 0.00202159189642 ko05145 Toxoplasmosis 19/516 126/7206 0.00233686509512 ko00051 Fructose and mannose metabolism 9/516 42/7206 0.00243632235256 ko04070 Phosphatidylinositol signaling system 17/516 112/7206 0.00262420750732 ko04110 Cell cycle 2/516 145/7206 0.00288214551991 ko05034 Alcoholism 6/516 238/7206 0.00292339757388 ko04630 Jak-STAT signaling pathway 19/516 132/7206 0.00313118426945 ko04020 Calcium signaling pathway 32/516 265/7206 0.00326842568162 ko05150 Staphylococcus aureus infection 8/516 36/7206 0.00330735558609 ko00590 Arachidonic acid metabolism 10/516 52/7206 0.00332589092369 ko03013 RNA transport 3/516 166/7206 0.00337291510603 ko05146 Amoebiasis 15/516 99/7206 0.0049051344172 ko05164 Influenza A 22/516 167/7206 0.0054612109715 ko00140 Steroid hormone biosynthesis 8/516 41/7206 0.00761930567262 ko00350 Tyrosine metabolism 7/516 33/7206 0.00771457467093 ko04611 Platelet activation 21/516 163/7206 0.00810262458817 ko04658 Th1 and Th2 cell differentiation 14/516 96/7206 0.00878158661913 ko05140 Leishmaniasis 12/516 75/7206 0.010253529649 ko04659 Th17 cell differentiation 15/516 106/7206 0.0114880427878 ko03015 mRNA surveillance pathway 1/516 93/7206 0.0139358959213 ko03320 PPAR signaling pathway 11/516 69/7206 0.0151093354418 ko04670 Leukocyte transendothelial migration 19/516 151/7206 0.0153500710963 ko04745 Phototransduction - fly 7/516 38/7206 0.0167307590218 ko04072 Phospholipase D signaling pathway 23/516 197/7206 0.017021719245 ko05340 Primary immunodeficiency 6/516 30/7206 0.01775169995 ko04668 TNF signaling pathway 16/516 120/7206 0.017990119393 ko04120 Ubiquitin mediated proteolysis 3/516 138/7206 0.0181324105809 ko04660 T cell receptor signaling pathway 16/516 124/7206 0.0204155461076 ko05224 Breast cancer 5/516 174/7206 0.0242981204983 ko04217 Necroptosis 21/516 178/7206 0.0255142967369 ko00565 Ether lipid metabolism 7/516 42/7206 0.0279755580164 ko05310 Asthma 4/516 17/7206 0.0292590689966 ko00360 Phenylalanine metabolism 4/516 17/7206 0.0292590689966 ko00950 Isoquinoline alkaloid biosynthesis 3/516 10/7206 0.0299733932248 ko04390 Hippo signaling pathway 6/516 188/7206 0.0305002550697 ko04022 cGMP-PKG signaling pathway 24/516 216/7206 0.0307684917652 ko05203 Viral carcinogenesis 11/516 277/7206 0.0322965855765 ko04666 Fc gamma R-mediated phagocytosis 15/516 122/7206 0.0331421585284 ko04662 B cell receptor signaling pathway 12/516 88/7206 0.0331846801175 ko00562 Inositol phosphate metabolism 12/516 89/7206 0.0343577329324 ko04270 Vascular smooth muscle contraction 18/516 154/7206 0.0380331840221 ko05144 Malaria 7/516 45/7206 0.0391778035381 ko04921 Oxytocin signaling pathway 23/516 209/7206 0.0395296908569 ko04933 AGE-RAGE signaling pathway in diabetic complications 16/516 135/7206 0.0416352202594 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/516 5/7206 0.0442622982198 ko00982 Drug metabolism - cytochrome P450 6/516 37/7206 0.0456414051698 ko05230 Central carbon metabolism in cancer 11/516 81/7206 0.0459043429565 ko04066 HIF-1 signaling pathway 15/516 123/7206 0.049048376798