ko pathway ratio_in_study ratio_in_pop p_value ko04070 Phosphatidylinositol signaling system 30/593 112/7206 3.48073059277e-09 ko04710 Circadian rhythm 16/593 43/7206 1.17267245683e-07 ko04020 Calcium signaling pathway 47/593 265/7206 3.06408763826e-07 ko05032 Morphine addiction 25/593 110/7206 2.09600730945e-06 ko04922 Glucagon signaling pathway 27/593 128/7206 3.80802953493e-06 ko04925 Aldosterone synthesis and secretion 23/593 105/7206 1.03136836467e-05 ko04726 Serotonergic synapse 27/593 137/7206 2.13458854193e-05 ko04921 Oxytocin signaling pathway 35/593 209/7206 5.14515785358e-05 ko05230 Central carbon metabolism in cancer 18/593 81/7206 7.6847146834e-05 ko03040 Spliceosome 1/593 145/7206 9.0777805515e-05 ko04713 Circadian entrainment 25/593 136/7206 0.000106997835057 ko03010 Ribosome 1/593 129/7206 0.000290380261687 ko04725 Cholinergic synapse 27/593 160/7206 0.000349347815971 ko00564 Glycerophospholipid metabolism 19/593 99/7206 0.000569831564175 ko04745 Phototransduction - fly 10/593 38/7206 0.00075061632448 ko00562 Inositol phosphate metabolism 17/593 89/7206 0.00125897582469 ko04724 Glutamatergic synapse 24/593 152/7206 0.00157254654496 ko04911 Insulin secretion 20/593 117/7206 0.0017194726851 ko04072 Phospholipase D signaling pathway 29/593 197/7206 0.00216514513253 ko04022 cGMP-PKG signaling pathway 31/593 216/7206 0.00225238696505 ko04727 GABAergic synapse 19/593 110/7206 0.00225824025187 ko05322 Systemic lupus erythematosus 3/593 151/7206 0.00234123532826 ko04711 Circadian rhythm - fly 5/593 13/7206 0.00273275190282 ko04720 Long-term potentiation 17/593 99/7206 0.00289047736654 ko04137 Mitophagy - animal 15/593 82/7206 0.00334442498259 ko05231 Choline metabolism in cancer 21/593 134/7206 0.0037106341701 ko03013 RNA transport 4/593 166/7206 0.00371142719479 ko04930 Type II diabetes mellitus 11/593 54/7206 0.00389633542123 ko00051 Fructose and mannose metabolism 9/593 42/7206 0.00617213532453 ko04750 Inflammatory mediator regulation of TRP channels 19/593 122/7206 0.00675017339663 ko04024 cAMP signaling pathway 36/593 279/7206 0.00718867420651 ko04919 Thyroid hormone signaling pathway 21/593 143/7206 0.00824486655079 ko05031 Amphetamine addiction 15/593 91/7206 0.0104824029024 ko05214 Glioma 13/593 79/7206 0.0127646622912 ko04110 Cell cycle 4/593 145/7206 0.013325904502 ko04140 Autophagy - animal 23/593 164/7206 0.0133865450865 ko04650 Natural killer cell mediated cytotoxicity 15/593 97/7206 0.0146130845293 ko00592 alpha-Linolenic acid metabolism 5/593 19/7206 0.0163357029643 ko00010 Glycolysis / Gluconeogenesis 12/593 74/7206 0.0185135454462 ko04152 AMPK signaling pathway 22/593 161/7206 0.0189061706207 ko04014 Ras signaling pathway 34/593 279/7206 0.0190904599856 ko05130 Pathogenic Escherichia coli infection 1/593 77/7206 0.0197939332052 ko00120 Primary bile acid biosynthesis 5/593 20/7206 0.0203440775187 ko04060 Cytokine-cytokine receptor interaction 25/593 191/7206 0.0220150132267 ko04080 Neuroactive ligand-receptor interaction 48/593 423/7206 0.0221037613153 ko04371 Apelin signaling pathway 23/593 177/7206 0.025874928842 ko04213 Longevity regulating pathway - multiple species 13/593 86/7206 0.0279701261229 ko04728 Dopaminergic synapse 24/593 185/7206 0.028637196578 ko04066 HIF-1 signaling pathway 17/593 123/7206 0.0302960774623 ko04068 FoxO signaling pathway 22/593 167/7206 0.030883462062 ko03015 mRNA surveillance pathway 2/593 93/7206 0.0335765573436 ko00240 Pyrimidine metabolism 3/593 110/7206 0.0337968131565 ko00561 Glycerolipid metabolism 10/593 63/7206 0.0361045266819 ko00471 D-Glutamine and D-glutamate metabolism 2/593 4/7206 0.0362681464948 ko05224 Breast cancer 7/593 174/7206 0.0363018360376 ko02010 ABC transporters 7/593 39/7206 0.0375460633453 ko04740 Olfactory transduction 12/593 80/7206 0.0377899477584 ko04136 Autophagy - other 6/593 31/7206 0.0378872043937 ko04138 Autophagy - yeast 12/593 81/7206 0.039842161794 ko00061 Fatty acid biosynthesis 4/593 17/7206 0.04560248151 ko05033 Nicotine addiction 9/593 56/7206 0.0457140459105 ko05321 Inflammatory bowel disease (IBD) 9/593 56/7206 0.0457140459105 ko04520 Adherens junction 3/593 103/7206 0.0458993449727 ko04657 IL-17 signaling pathway 2/593 87/7206 0.0463906482206