ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	201/1230	423/7206	3.86520399305e-51
ko04724	Glutamatergic synapse	93/1230	152/7206	6.16353182615e-35
ko05033	Nicotine addiction	50/1230	56/7206	1.98602635213e-32
ko05032	Morphine addiction	70/1230	110/7206	5.03247609917e-28
ko04713	Circadian entrainment	79/1230	136/7206	1.28392739815e-27
ko04727	GABAergic synapse	68/1230	110/7206	3.72384008431e-26
ko04728	Dopaminergic synapse	90/1230	185/7206	9.17149649242e-24
ko04725	Cholinergic synapse	76/1230	160/7206	1.95742703627e-19
ko04721	Synaptic vesicle cycle	49/1230	80/7206	6.41623430316e-19
ko04723	Retrograde endocannabinoid signaling	79/1230	175/7206	1.7370938269e-18
ko04024	cAMP signaling pathway	103/1230	279/7206	4.42119059558e-16
ko04020	Calcium signaling pathway	97/1230	265/7206	6.26866946803e-15
ko04911	Insulin secretion	56/1230	117/7206	8.22592735643e-15
ko04744	Phototransduction	27/1230	36/7206	2.82691475829e-14
ko04726	Serotonergic synapse	60/1230	137/7206	1.35435098326e-13
ko04742	Taste transduction	36/1230	61/7206	1.579607672e-13
ko04921	Oxytocin signaling pathway	77/1230	209/7206	3.77767099459e-12
ko05031	Amphetamine addiction	44/1230	91/7206	4.18985432888e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1230	205/7206	4.06079885694e-11
ko04740	Olfactory transduction	39/1230	80/7206	5.12795451062e-11
ko03040	Spliceosome	1/1230	145/7206	7.15473496692e-11
ko04720	Long-term potentiation	44/1230	99/7206	1.4321488701e-10
ko05203	Viral carcinogenesis	15/1230	277/7206	4.51723868196e-09
ko05030	Cocaine addiction	33/1230	73/7206	1.74209488883e-08
ko04970	Salivary secretion	39/1230	95/7206	4.13121075088e-08
ko04925	Aldosterone synthesis and secretion	40/1230	105/7206	2.45676135975e-07
ko05322	Systemic lupus erythematosus	5/1230	151/7206	2.54855227667e-07
ko04360	Axon guidance	71/1230	233/7206	3.05671876729e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1230	74/7206	3.91997695806e-07
ko03013	RNA transport	7/1230	166/7206	5.69179555274e-07
ko04971	Gastric acid secretion	37/1230	98/7206	9.04909764255e-07
ko05164	Influenza A	8/1230	167/7206	1.96264099378e-06
ko04070	Phosphatidylinositol signaling system	39/1230	112/7206	5.3132817802e-06
ko04141	Protein processing in endoplasmic reticulum	11/1230	184/7206	9.75534540794e-06
ko04010	MAPK signaling pathway	85/1230	321/7206	1.35208752134e-05
ko04060	Cytokine-cytokine receptor interaction	12/1230	191/7206	1.39937977309e-05
ko04745	Phototransduction - fly	18/1230	38/7206	1.43308831537e-05
ko04022	cGMP-PKG signaling pathway	61/1230	216/7206	3.08267425788e-05
ko04621	NOD-like receptor signaling pathway	9/1230	157/7206	3.54869735556e-05
ko04711	Circadian rhythm - fly	9/1230	13/7206	4.43218247769e-05
ko04110	Cell cycle	8/1230	145/7206	4.6789030044e-05
ko04514	Cell adhesion molecules (CAMs)	41/1230	130/7206	4.69403119182e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1230	79/7206	6.59735256798e-05
ko04612	Antigen processing and presentation	2/1230	77/7206	0.000108135471443
ko03008	Ribosome biogenesis in eukaryotes	2/1230	79/7206	0.000112395972436
ko04976	Bile secretion	28/1230	80/7206	0.000121903700536
ko05168	Herpes simplex infection	13/1230	182/7206	0.000127167647664
ko05140	Leishmaniasis	2/1230	75/7206	0.000160533810358
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1230	59/7206	0.000170973506851
ko04072	Phospholipase D signaling pathway	54/1230	197/7206	0.000233416384879
ko05205	Proteoglycans in cancer	25/1230	271/7206	0.000268815125505
ko05161	Hepatitis B	13/1230	173/7206	0.000312130686691
ko05169	Epstein-Barr virus infection	17/1230	206/7206	0.000323322512696
ko05162	Measles	7/1230	120/7206	0.000342349316682
ko04710	Circadian rhythm	17/1230	43/7206	0.000386180754265
ko04730	Long-term depression	26/1230	78/7206	0.000399934898843
ko04924	Renin secretion	28/1230	86/7206	0.000418056986728
ko04610	Complement and coagulation cascades	3/1230	79/7206	0.000464105835275
ko04972	Pancreatic secretion	34/1230	111/7206	0.000486872025992
ko05414	Dilated cardiomyopathy	34/1230	112/7206	0.000519186716297
ko04966	Collecting duct acid secretion	12/1230	26/7206	0.000532955052578
ko04750	Inflammatory mediator regulation of TRP channels	36/1230	122/7206	0.00058622865819
ko04540	Gap junction	37/1230	128/7206	0.000791120444421
ko00520	Amino sugar and nucleotide sugar metabolism	1/1230	55/7206	0.000853937925178
ko04064	NF-kappa B signaling pathway	5/1230	96/7206	0.000877640759572
ko04260	Cardiac muscle contraction	30/1230	98/7206	0.000975689532893
ko00240	Pyrimidine metabolism	7/1230	110/7206	0.0012939510048
ko05110	Vibrio cholerae infection	21/1230	63/7206	0.00193063436468
ko04657	IL-17 signaling pathway	5/1230	87/7206	0.00244464948156
ko04146	Peroxisome	5/1230	89/7206	0.00251954760745
ko04120	Ubiquitin mediated proteolysis	11/1230	138/7206	0.00278246440598
ko03420	Nucleotide excision repair	1/1230	46/7206	0.00282819436616
ko05321	Inflammatory bowel disease (IBD)	2/1230	56/7206	0.00375114679543
ko00480	Glutathione metabolism	2/1230	55/7206	0.00375514063198
ko03022	Basal transcription factors	1/1230	44/7206	0.00425537024989
ko04014	Ras signaling pathway	66/1230	279/7206	0.00435356826289
ko05144	Malaria	1/1230	45/7206	0.00436121074771
ko00071	Fatty acid degradation	1/1230	45/7206	0.00436121074771
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1230	14/7206	0.00467803063922
ko04923	Regulation of lipolysis in adipocytes	23/1230	77/7206	0.00542693263645
ko04622	RIG-I-like receptor signaling pathway	3/1230	62/7206	0.00623655712633
ko05166	HTLV-I infection	33/1230	292/7206	0.00677584725928
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1230	182/7206	0.00699088052463
ko00590	Arachidonic acid metabolism	2/1230	52/7206	0.00829673544531
ko04510	Focal adhesion	26/1230	240/7206	0.00859113030505
ko04658	Th1 and Th2 cell differentiation	7/1230	96/7206	0.00880715049937
ko04210	Apoptosis	18/1230	180/7206	0.00890420242933
ko05133	Pertussis	6/1230	87/7206	0.00917314116537
ko04915	Estrogen signaling pathway	34/1230	131/7206	0.00950277039268
ko00562	Inositol phosphate metabolism	25/1230	89/7206	0.00985803555073
ko05016	Huntington's disease	23/1230	215/7206	0.0098638024365
ko05215	Prostate cancer	9/1230	111/7206	0.0103662614678
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1230	100/7206	0.0107908601517
ko04217	Necroptosis	18/1230	178/7206	0.0113464353115
ko05219	Bladder cancer	2/1230	48/7206	0.0117449091014
ko03018	RNA degradation	6/1230	84/7206	0.0124827808921
ko04630	Jak-STAT signaling pathway	12/1230	132/7206	0.0135912002182
ko00630	Glyoxylate and dicarboxylate metabolism	1/1230	38/7206	0.0149985987905
ko04620	Toll-like receptor signaling pathway	8/1230	100/7206	0.0150895702059
ko05131	Shigellosis	6/1230	82/7206	0.0171674657664
ko00290	Valine, leucine and isoleucine biosynthesis	3/1230	4/7206	0.0173160874104
ko00310	Lysine degradation	5/1230	73/7206	0.0179632318306
ko00280	Valine, leucine and isoleucine degradation	3/1230	54/7206	0.0182528255757
ko04640	Hematopoietic cell lineage	4/1230	64/7206	0.0184063664158
ko04115	p53 signaling pathway	5/1230	74/7206	0.0184293403494
ko04371	Apelin signaling pathway	42/1230	177/7206	0.0199781346498
ko04918	Thyroid hormone synthesis	23/1230	86/7206	0.0208278080513
ko00860	Porphyrin and chlorophyll metabolism	1/1230	34/7206	0.0216493007048
ko00500	Starch and sucrose metabolism	1/1230	35/7206	0.021936032804
ko04964	Proximal tubule bicarbonate reclamation	10/1230	29/7206	0.0221876104229
ko05145	Toxoplasmosis	12/1230	126/7206	0.0226150215969
ko04626	Plant-pathogen interaction	7/1230	18/7206	0.0231946305625
ko00330	Arginine and proline metabolism	4/1230	61/7206	0.0255342139085
ko04912	GnRH signaling pathway	30/1230	122/7206	0.0379929395498
ko04137	Mitophagy - animal	7/1230	82/7206	0.0382240110704
ko05212	Pancreatic cancer	7/1230	83/7206	0.0385965907653
ko05132	Salmonella infection	9/1230	98/7206	0.0413157301223
ko04930	Type II diabetes mellitus	15/1230	54/7206	0.0446363401089
ko04810	Regulation of actin cytoskeleton	33/1230	264/7206	0.0453156892328
ko05320	Autoimmune thyroid disease	1/1230	29/7206	0.0482284370747