ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 51/418 191/7206 2.60548356468e-21 ko04380 Osteoclast differentiation 35/418 134/7206 1.36218094122e-14 ko04621 NOD-like receptor signaling pathway 38/418 157/7206 1.40967396428e-14 ko04064 NF-kappa B signaling pathway 27/418 96/7206 2.33769726604e-12 ko05145 Toxoplasmosis 31/418 126/7206 2.65796889327e-12 ko05164 Influenza A 36/418 167/7206 3.03044917142e-12 ko04650 Natural killer cell mediated cytotoxicity 27/418 97/7206 3.0686313534e-12 ko05321 Inflammatory bowel disease (IBD) 20/418 56/7206 1.34445668366e-11 ko05140 Leishmaniasis 23/418 75/7206 1.44394366654e-11 ko05340 Primary immunodeficiency 15/418 30/7206 1.53991995404e-11 ko04659 Th17 cell differentiation 27/418 106/7206 3.00720592826e-11 ko04217 Necroptosis 35/418 178/7206 9.63991828763e-11 ko05330 Allograft rejection 13/418 24/7206 9.7511282639e-11 ko05150 Staphylococcus aureus infection 15/418 36/7206 4.00078918595e-10 ko05152 Tuberculosis 35/418 187/7206 4.00858030301e-10 ko05162 Measles 27/418 120/7206 6.3564036658e-10 ko05168 Herpes simplex infection 34/418 182/7206 7.61192724475e-10 ko04660 T cell receptor signaling pathway 27/418 124/7206 1.38559063691e-09 ko05320 Autoimmune thyroid disease 13/418 29/7206 2.02803839026e-09 ko04672 Intestinal immune network for IgA production 14/418 37/7206 7.03635596356e-09 ko05332 Graft-versus-host disease 10/418 18/7206 1.11644482791e-08 ko04658 Th1 and Th2 cell differentiation 22/418 96/7206 1.78089617236e-08 ko04630 Jak-STAT signaling pathway 26/418 132/7206 2.61064861224e-08 ko04620 Toll-like receptor signaling pathway 22/418 100/7206 3.94159941665e-08 ko04612 Antigen processing and presentation 19/418 77/7206 4.76289542172e-08 ko04640 Hematopoietic cell lineage 17/418 64/7206 7.59799127732e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 29/418 191/7206 1.44489037905e-06 ko05310 Asthma 8/418 17/7206 1.83417329098e-06 ko05323 Rheumatoid arthritis 18/418 89/7206 2.54137235394e-06 ko05144 Malaria 12/418 45/7206 6.18619135101e-06 ko04940 Type I diabetes mellitus 10/418 32/7206 7.87701284143e-06 ko05133 Pertussis 17/418 87/7206 7.89181717969e-06 ko04662 B cell receptor signaling pathway 17/418 88/7206 9.26907669728e-06 ko04062 Chemokine signaling pathway 28/418 201/7206 1.71436889698e-05 ko04610 Complement and coagulation cascades 15/418 79/7206 3.85135648028e-05 ko04622 RIG-I-like receptor signaling pathway 13/418 62/7206 4.26746497848e-05 ko05142 Chagas disease (American trypanosomiasis) 20/418 130/7206 5.23207066413e-05 ko05161 Hepatitis B 24/418 173/7206 8.28367344875e-05 ko04623 Cytosolic DNA-sensing pathway 10/418 41/7206 8.54275220377e-05 ko05034 Alcoholism 2/418 238/7206 0.000110435069243 ko04145 Phagosome 21/418 162/7206 0.000465979029126 ko04723 Retrograde endocannabinoid signaling 1/418 175/7206 0.000482299668119 ko00120 Primary bile acid biosynthesis 6/418 20/7206 0.00070922537191 ko04210 Apoptosis 22/418 180/7206 0.000914504583379 ko03050 Proteasome 10/418 54/7206 0.000926165310026 ko05132 Salmonella infection 14/418 98/7206 0.0014519043499 ko04514 Cell adhesion molecules (CAMs) 17/418 130/7206 0.00168949778483 ko04611 Platelet activation 20/418 163/7206 0.00172279323652 ko04728 Dopaminergic synapse 2/418 185/7206 0.00209309443744 ko04668 TNF signaling pathway 16/418 120/7206 0.0021728905651 ko04137 Mitophagy - animal 12/418 82/7206 0.00253215566146 ko05206 MicroRNAs in cancer 2/418 177/7206 0.00297786955663 ko04916 Melanogenesis 1/418 142/7206 0.00323729484584 ko03040 Spliceosome 1/418 145/7206 0.00332193717368 ko05160 Hepatitis C 18/418 153/7206 0.00417211349902 ko05224 Breast cancer 2/418 174/7206 0.00443071805963 ko04144 Endocytosis 32/418 342/7206 0.00621800557341 ko04390 Hippo signaling pathway 3/418 188/7206 0.00686044372882 ko03010 Ribosome 1/418 129/7206 0.00688645964202 ko05146 Amoebiasis 13/418 99/7206 0.00708528348883 ko04142 Lysosome 17/418 151/7206 0.00747576997175 ko00590 Arachidonic acid metabolism 8/418 52/7206 0.00950325275173 ko04310 Wnt signaling pathway 3/418 181/7206 0.00956979745749 ko05169 Epstein-Barr virus infection 21/418 206/7206 0.00983328456786 ko05134 Legionellosis 10/418 74/7206 0.00989945197336 ko04724 Glutamatergic synapse 2/418 152/7206 0.0125104923007 ko04664 Fc epsilon RI signaling pathway 10/418 77/7206 0.0129616982924 ko05416 Viral myocarditis 8/418 55/7206 0.0132225348149 ko04530 Tight junction 5/418 228/7206 0.0136605862148 ko05166 HTLV-I infection 27/418 292/7206 0.0146161159347 ko04911 Insulin secretion 1/418 117/7206 0.0147362898607 ko04110 Cell cycle 2/418 145/7206 0.0176810571682 ko04910 Insulin signaling pathway 3/418 172/7206 0.0190235223362 ko04012 ErbB signaling pathway 1/418 109/7206 0.0211002463441 ko04713 Circadian entrainment 2/418 136/7206 0.0244451723049 ko04114 Oocyte meiosis 2/418 139/7206 0.0252510382112 ko04152 AMPK signaling pathway 3/418 161/7206 0.0255329624941 ko04550 Signaling pathways regulating pluripotency of stem cells 3/418 165/7206 0.0263061329424 ko00980 Metabolism of xenobiotics by cytochrome P450 6/418 40/7206 0.0263772289889 ko04666 Fc gamma R-mediated phagocytosis 13/418 122/7206 0.0295867737084 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/418 5/7206 0.0298601693123 ko05418 Fluid shear stress and atherosclerosis 17/418 173/7206 0.0306133214335 ko04360 Axon guidance 6/418 233/7206 0.0313079952335 ko04925 Aldosterone synthesis and secretion 1/418 105/7206 0.0316074826625 ko04922 Glucagon signaling pathway 2/418 128/7206 0.0341527807222 ko04540 Gap junction 2/418 128/7206 0.0341527807222 ko05143 African trypanosomiasis 5/418 32/7206 0.0353507105028 ko05010 Alzheimer's disease 5/418 202/7206 0.0449798632148 ko04912 GnRH signaling pathway 2/418 122/7206 0.0481046488514 ko01522 Endocrine resistance 2/418 124/7206 0.0490083821694