ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 29/336 157/7206 1.12665539742e-10 ko05164 Influenza A 28/336 167/7206 2.42456121396e-09 ko05168 Herpes simplex infection 29/336 182/7206 4.20298135306e-09 ko05162 Measles 22/336 120/7206 2.50057998277e-08 ko05340 Primary immunodeficiency 11/336 30/7206 4.73840383072e-08 ko04064 NF-kappa B signaling pathway 19/336 96/7206 6.40855242148e-08 ko05145 Toxoplasmosis 21/336 126/7206 2.86773069106e-07 ko04630 Jak-STAT signaling pathway 21/336 132/7206 6.41271142042e-07 ko05321 Inflammatory bowel disease (IBD) 13/336 56/7206 1.19665440643e-06 ko05140 Leishmaniasis 15/336 75/7206 1.39397673194e-06 ko04612 Antigen processing and presentation 15/336 77/7206 1.98092254528e-06 ko04060 Cytokine-cytokine receptor interaction 25/336 191/7206 2.3867481108e-06 ko04380 Osteoclast differentiation 20/336 134/7206 3.32484573651e-06 ko04217 Necroptosis 23/336 178/7206 7.60354531232e-06 ko04658 Th1 and Th2 cell differentiation 16/336 96/7206 7.67149231567e-06 ko05332 Graft-versus-host disease 7/336 18/7206 9.17929317504e-06 ko05133 Pertussis 15/336 87/7206 9.65924140715e-06 ko00120 Primary bile acid biosynthesis 7/336 20/7206 2.06184892099e-05 ko04659 Th17 cell differentiation 16/336 106/7206 2.79049561867e-05 ko05150 Staphylococcus aureus infection 9/336 36/7206 2.88011096212e-05 ko04210 Apoptosis 22/336 180/7206 2.92132303897e-05 ko04620 Toll-like receptor signaling pathway 15/336 100/7206 5.35196783591e-05 ko05330 Allograft rejection 7/336 24/7206 7.82994024245e-05 ko05323 Rheumatoid arthritis 13/336 89/7206 0.00022087084806 ko05034 Alcoholism 1/336 238/7206 0.000233505959693 ko05320 Autoimmune thyroid disease 7/336 29/7206 0.0002885922152 ko04668 TNF signaling pathway 15/336 120/7206 0.000428232249167 ko04622 RIG-I-like receptor signaling pathway 10/336 62/7206 0.000523515129017 ko05152 Tuberculosis 20/336 187/7206 0.000537240947484 ko04940 Type I diabetes mellitus 7/336 32/7206 0.000551587299557 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/336 191/7206 0.000649439949905 ko05160 Hepatitis C 17/336 153/7206 0.000728725482159 ko05144 Malaria 8/336 45/7206 0.000975056756359 ko05142 Chagas disease (American trypanosomiasis) 15/336 130/7206 0.00100293579925 ko04080 Neuroactive ligand-receptor interaction 7/336 423/7206 0.00118024566811 ko05161 Hepatitis B 18/336 173/7206 0.00134956286123 ko04137 Mitophagy - animal 11/336 82/7206 0.00137800840939 ko04672 Intestinal immune network for IgA production 7/336 37/7206 0.00138049878218 ko04650 Natural killer cell mediated cytotoxicity 12/336 97/7206 0.0017336244566 ko05134 Legionellosis 10/336 74/7206 0.00213107705847 ko04917 Prolactin signaling pathway 11/336 87/7206 0.00223977910555 ko04728 Dopaminergic synapse 1/336 185/7206 0.00229302269045 ko04390 Hippo signaling pathway 1/336 188/7206 0.00233279396773 ko04662 B cell receptor signaling pathway 11/336 88/7206 0.00245584786248 ko04623 Cytosolic DNA-sensing pathway 7/336 41/7206 0.00256890888567 ko04723 Retrograde endocannabinoid signaling 1/336 175/7206 0.00334351246541 ko04611 Platelet activation 16/336 163/7206 0.00412789158 ko04660 T cell receptor signaling pathway 13/336 124/7206 0.00751576472199 ko03013 RNA transport 1/336 166/7206 0.0075456840124 ko04146 Peroxisome 10/336 89/7206 0.00814891524419 ko04640 Hematopoietic cell lineage 8/336 64/7206 0.00929747785963 ko00920 Sulfur metabolism 3/336 10/7206 0.00943822074116 ko00592 alpha-Linolenic acid metabolism 4/336 19/7206 0.0103145331651 ko04020 Calcium signaling pathway 4/336 265/7206 0.0105269730289 ko00140 Steroid hormone biosynthesis 6/336 41/7206 0.0111050612646 ko03050 Proteasome 7/336 54/7206 0.0120736429489 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/336 4/7206 0.0122177218569 ko00643 Styrene degradation 2/336 4/7206 0.0122177218569 ko05131 Shigellosis 9/336 82/7206 0.013648890837 ko04710 Circadian rhythm 6/336 43/7206 0.0139318316466 ko03040 Spliceosome 1/336 145/7206 0.0150605282413 ko04110 Cell cycle 1/336 145/7206 0.0150605282413 ko04062 Chemokine signaling pathway 17/336 201/7206 0.0160845083318 ko05224 Breast cancer 2/336 174/7206 0.0175936251475 ko04310 Wnt signaling pathway 2/336 181/7206 0.0181959024386 ko04657 IL-17 signaling pathway 9/336 87/7206 0.0195246145327 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/336 5/7206 0.0197383850016 ko00500 Starch and sucrose metabolism 5/336 35/7206 0.0219654076086 ko04145 Phagosome 14/336 162/7206 0.0223626319206 ko00220 Arginine biosynthesis 4/336 24/7206 0.0235556043517 ko05132 Salmonella infection 10/336 98/7206 0.0245317732821 ko04360 Axon guidance 4/336 233/7206 0.0259387379856 ko00362 Benzoate degradation 2/336 6/7206 0.0287031804839 ko04932 Non-alcoholic fatty liver disease (NAFLD) 15/336 182/7206 0.0302561711282 ko03010 Ribosome 1/336 129/7206 0.0317069408083 ko00590 Arachidonic acid metabolism 6/336 52/7206 0.0328713978839 ko05020 Prion diseases 5/336 40/7206 0.0369003312563 ko03320 PPAR signaling pathway 7/336 69/7206 0.0408242988474 ko05416 Viral myocarditis 6/336 55/7206 0.0417227649235 ko05310 Asthma 3/336 17/7206 0.042027685943 ko00565 Ether lipid metabolism 5/336 42/7206 0.0442695994769 ko00401 Novobiocin biosynthesis 1/336 1/7206 0.0466278101584