ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	182/1074	423/7206	1.67167385883e-47
ko05033	Nicotine addiction	49/1074	56/7206	9.67908591856e-34
ko04724	Glutamatergic synapse	86/1074	152/7206	2.28242345897e-33
ko05032	Morphine addiction	69/1074	110/7206	8.07595614259e-31
ko04727	GABAergic synapse	68/1074	110/7206	8.06773205689e-30
ko04713	Circadian entrainment	68/1074	136/7206	2.10885376002e-22
ko04728	Dopaminergic synapse	80/1074	185/7206	4.6823769424e-21
ko04723	Retrograde endocannabinoid signaling	77/1074	175/7206	7.33113410947e-21
ko04725	Cholinergic synapse	70/1074	160/7206	6.87719796244e-19
ko04721	Synaptic vesicle cycle	46/1074	80/7206	1.03744118175e-18
ko04744	Phototransduction	27/1074	36/7206	8.69034644137e-16
ko04726	Serotonergic synapse	58/1074	137/7206	4.64153217039e-15
ko04742	Taste transduction	35/1074	61/7206	1.69760191096e-14
ko04024	cAMP signaling pathway	91/1074	279/7206	2.78704169141e-14
ko04911	Insulin secretion	50/1074	117/7206	2.40817788667e-13
ko04020	Calcium signaling pathway	84/1074	265/7206	1.78635320322e-12
ko04921	Oxytocin signaling pathway	68/1074	209/7206	7.41360832393e-11
ko04261	Adrenergic signaling in cardiomyocytes	67/1074	205/7206	9.15197686328e-11
ko03040	Spliceosome	1/1074	145/7206	2.19803127453e-09
ko05031	Amphetamine addiction	36/1074	91/7206	7.08986796059e-09
ko04740	Olfactory transduction	33/1074	80/7206	8.75303984082e-09
ko05203	Viral carcinogenesis	13/1074	277/7206	6.18936900455e-08
ko04720	Long-term potentiation	36/1074	99/7206	9.32000759721e-08
ko04970	Salivary secretion	35/1074	95/7206	9.64339947596e-08
ko05030	Cocaine addiction	29/1074	73/7206	1.86475222845e-07
ko04925	Aldosterone synthesis and secretion	35/1074	105/7206	2.29575110046e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1074	74/7206	3.4891038561e-06
ko05322	Systemic lupus erythematosus	5/1074	151/7206	4.56001009159e-06
ko04971	Gastric acid secretion	32/1074	98/7206	9.27812281888e-06
ko04972	Pancreatic secretion	35/1074	111/7206	9.51413447875e-06
ko04072	Phospholipase D signaling pathway	53/1074	197/7206	9.66248472834e-06
ko04060	Cytokine-cytokine receptor interaction	9/1074	191/7206	1.13091215208e-05
ko03013	RNA transport	7/1074	166/7206	1.30703695596e-05
ko04010	MAPK signaling pathway	76/1074	321/7206	1.93550707009e-05
ko04022	cGMP-PKG signaling pathway	55/1074	216/7206	3.80788978485e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1074	79/7206	4.59493708754e-05
ko04514	Cell adhesion molecules (CAMs)	37/1074	130/7206	5.47873822571e-05
ko05164	Influenza A	8/1074	167/7206	5.87186459554e-05
ko05205	Proteoglycans in cancer	19/1074	271/7206	8.0185331564e-05
ko05168	Herpes simplex infection	10/1074	182/7206	8.34673474923e-05
ko04610	Complement and coagulation cascades	1/1074	79/7206	8.36657901337e-05
ko04120	Ubiquitin mediated proteolysis	6/1074	138/7206	0.00014221203237
ko04966	Collecting duct acid secretion	12/1074	26/7206	0.000143433745843
ko04260	Cardiac muscle contraction	29/1074	98/7206	0.000161863350201
ko04070	Phosphatidylinositol signaling system	32/1074	112/7206	0.000230275025963
ko04730	Long-term depression	24/1074	78/7206	0.000319347574864
ko04360	Axon guidance	55/1074	233/7206	0.000346534924854
ko04110	Cell cycle	8/1074	145/7206	0.000564147710931
ko03008	Ribosome biogenesis in eukaryotes	2/1074	79/7206	0.000638075641295
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1074	59/7206	0.000686742283865
ko04141	Protein processing in endoplasmic reticulum	12/1074	184/7206	0.000703483419087
ko04745	Phototransduction - fly	14/1074	38/7206	0.000709470083823
ko05140	Leishmaniasis	2/1074	75/7206	0.00090739525886
ko05162	Measles	6/1074	120/7206	0.00105984268481
ko05414	Dilated cardiomyopathy	30/1074	112/7206	0.00111291685178
ko04621	NOD-like receptor signaling pathway	10/1074	157/7206	0.00137468686024
ko05161	Hepatitis B	12/1074	173/7206	0.00163907179396
ko04915	Estrogen signaling pathway	33/1074	131/7206	0.00177944293976
ko05110	Vibrio cholerae infection	19/1074	63/7206	0.00194546084404
ko04964	Proximal tubule bicarbonate reclamation	11/1074	29/7206	0.0019967322759
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1074	182/7206	0.00205685539766
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1074	14/7206	0.00210081064091
ko04540	Gap junction	32/1074	128/7206	0.0024171636962
ko05169	Epstein-Barr virus infection	16/1074	206/7206	0.00271774622705
ko04612	Antigen processing and presentation	3/1074	77/7206	0.00337265063722
ko00480	Glutathione metabolism	1/1074	55/7206	0.00339210551905
ko04976	Bile secretion	22/1074	80/7206	0.00379854230759
ko04146	Peroxisome	4/1074	89/7206	0.00384084508053
ko04640	Hematopoietic cell lineage	2/1074	64/7206	0.00418703814756
ko05016	Huntington's disease	18/1074	215/7206	0.00468438077352
ko03018	RNA degradation	4/1074	84/7206	0.00518349853668
ko04064	NF-kappa B signaling pathway	5/1074	96/7206	0.005479421929
ko04711	Circadian rhythm - fly	6/1074	13/7206	0.00724205865807
ko04710	Circadian rhythm	13/1074	43/7206	0.0088111680859
ko04924	Renin secretion	22/1074	86/7206	0.00885212532296
ko04750	Inflammatory mediator regulation of TRP channels	29/1074	122/7206	0.00964945220705
ko00240	Pyrimidine metabolism	7/1074	110/7206	0.00965946187837
ko04140	Autophagy - animal	13/1074	164/7206	0.010252500945
ko05144	Malaria	1/1074	45/7206	0.0105675550503
ko00071	Fatty acid degradation	1/1074	45/7206	0.0105675550503
ko03420	Nucleotide excision repair	1/1074	46/7206	0.0108425959522
ko05321	Inflammatory bowel disease (IBD)	2/1074	56/7206	0.0129452720362
ko04630	Jak-STAT signaling pathway	10/1074	132/7206	0.0135087241272
ko04658	Th1 and Th2 cell differentiation	6/1074	96/7206	0.013551664058
ko04218	Cellular senescence	15/1074	177/7206	0.0135789665663
ko05133	Pertussis	5/1074	87/7206	0.0142901205876
ko04014	Ras signaling pathway	56/1074	279/7206	0.0162252876162
ko03022	Basal transcription factors	1/1074	44/7206	0.0167315710454
ko04137	Mitophagy - animal	5/1074	82/7206	0.0192675999204
ko04622	RIG-I-like receptor signaling pathway	3/1074	62/7206	0.0196693094172
ko00310	Lysine degradation	4/1074	73/7206	0.0198146453184
ko04115	p53 signaling pathway	4/1074	74/7206	0.0201347757386
ko04918	Thyroid hormone synthesis	21/1074	86/7206	0.0208481421041
ko05145	Toxoplasmosis	10/1074	126/7206	0.0230815121468
ko05166	HTLV-I infection	30/1074	292/7206	0.023217040956
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1074	40/7206	0.0235957377669
ko04217	Necroptosis	16/1074	178/7206	0.0246852531945
ko03320	PPAR signaling pathway	4/1074	69/7206	0.0274038576438
ko00330	Arginine and proline metabolism	3/1074	61/7206	0.0282220802941
ko00512	Mucin type O-glycan biosynthesis	9/1074	29/7206	0.0304499475826
ko04371	Apelin signaling pathway	37/1074	177/7206	0.031771742082
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1074	100/7206	0.0324376848507
ko04930	Type II diabetes mellitus	14/1074	54/7206	0.032596236542
ko04657	IL-17 signaling pathway	6/1074	87/7206	0.0332646887993
ko00562	Inositol phosphate metabolism	21/1074	89/7206	0.0342792858172
ko00982	Drug metabolism - cytochrome P450	1/1074	37/7206	0.0347957071053
ko00630	Glyoxylate and dicarboxylate metabolism	1/1074	38/7206	0.0359050849169
ko04350	TGF-beta signaling pathway	8/1074	103/7206	0.0368611009378
ko00260	Glycine, serine and threonine metabolism	2/1074	48/7206	0.0390993703941
ko05219	Bladder cancer	2/1074	48/7206	0.0390993703941
ko05418	Fluid shear stress and atherosclerosis	16/1074	173/7206	0.0391813214923
ko05012	Parkinson's disease	14/1074	155/7206	0.0394760674856
ko04210	Apoptosis	17/1074	180/7206	0.0431458578032
ko04620	Toll-like receptor signaling pathway	8/1074	100/7206	0.0482185411294