ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 43/604 191/7206 1.04816312066e-09 ko00120 Primary bile acid biosynthesis 11/604 20/7206 1.09408485735e-07 ko04610 Complement and coagulation cascades 21/604 79/7206 1.24651865049e-06 ko05034 Alcoholism 3/604 238/7206 2.23537084059e-06 ko04621 NOD-like receptor signaling pathway 32/604 157/7206 2.53625535304e-06 ko04380 Osteoclast differentiation 28/604 134/7206 4.38584039652e-06 ko04650 Natural killer cell mediated cytotoxicity 22/604 97/7206 1.19087011386e-05 ko05340 Primary immunodeficiency 11/604 30/7206 1.63090639072e-05 ko05150 Staphylococcus aureus infection 12/604 36/7206 2.06231807803e-05 ko03013 RNA transport 2/604 166/7206 9.68682852989e-05 ko04658 Th1 and Th2 cell differentiation 20/604 96/7206 0.000106318144192 ko04064 NF-kappa B signaling pathway 20/604 96/7206 0.000106318144192 ko04146 Peroxisome 19/604 89/7206 0.000111668892653 ko05162 Measles 23/604 120/7206 0.000153126983036 ko05321 Inflammatory bowel disease (IBD) 14/604 56/7206 0.000153570503925 ko05164 Influenza A 29/604 167/7206 0.000166929601925 ko00350 Tyrosine metabolism 10/604 33/7206 0.000249048111494 ko00360 Phenylalanine metabolism 7/604 17/7206 0.000258831737192 ko05145 Toxoplasmosis 23/604 126/7206 0.000287724639952 ko03010 Ribosome 1/604 129/7206 0.000295346243135 ko04137 Mitophagy - animal 17/604 82/7206 0.000366700826787 ko05140 Leishmaniasis 16/604 75/7206 0.000386195947434 ko04659 Th17 cell differentiation 20/604 106/7206 0.000518152333232 ko00592 alpha-Linolenic acid metabolism 7/604 19/7206 0.000577961552566 ko03040 Spliceosome 2/604 145/7206 0.000659909167673 ko04110 Cell cycle 2/604 145/7206 0.000659909167673 ko04620 Toll-like receptor signaling pathway 19/604 100/7206 0.000692241497996 ko05144 Malaria 11/604 45/7206 0.000948823505269 ko00071 Fatty acid degradation 11/604 45/7206 0.000948823505269 ko04660 T cell receptor signaling pathway 21/604 124/7206 0.00158825618929 ko04390 Hippo signaling pathway 5/604 188/7206 0.00194358214492 ko05320 Autoimmune thyroid disease 8/604 29/7206 0.00204448859868 ko04630 Jak-STAT signaling pathway 22/604 132/7206 0.00207817555674 ko04710 Circadian rhythm 10/604 43/7206 0.00240031095944 ko05133 Pertussis 16/604 87/7206 0.00255089341963 ko04728 Dopaminergic synapse 5/604 185/7206 0.00273884205161 ko05330 Allograft rejection 7/604 24/7206 0.00274251839316 ko00590 Arachidonic acid metabolism 11/604 52/7206 0.00329814038159 ko05168 Herpes simplex infection 27/604 182/7206 0.00391845695264 ko03015 mRNA surveillance pathway 1/604 93/7206 0.00429301519983 ko04622 RIG-I-like receptor signaling pathway 12/604 62/7206 0.00473580305018 ko04723 Retrograde endocannabinoid signaling 5/604 175/7206 0.00517236791326 ko00140 Steroid hormone biosynthesis 9/604 41/7206 0.00588877357568 ko04623 Cytosolic DNA-sensing pathway 9/604 41/7206 0.00588877357568 ko04111 Cell cycle - yeast 1/604 90/7206 0.0063441435522 ko03320 PPAR signaling pathway 13/604 69/7206 0.00657689732815 ko00950 Isoquinoline alkaloid biosynthesis 4/604 10/7206 0.00681178440612 ko05167 Kaposi's sarcoma-associated herpesvirus infection 27/604 191/7206 0.0074199820907 ko00362 Benzoate degradation 3/604 6/7206 0.00966637251506 ko04640 Hematopoietic cell lineage 12/604 64/7206 0.00976880328346 ko04662 B cell receptor signaling pathway 15/604 88/7206 0.00990296180196 ko04672 Intestinal immune network for IgA production 8/604 37/7206 0.0101394389297 ko00982 Drug metabolism - cytochrome P450 8/604 37/7206 0.0101394389297 ko04612 Antigen processing and presentation 13/604 77/7206 0.0120830055211 ko04721 Synaptic vesicle cycle 1/604 80/7206 0.0134674176849 ko05332 Graft-versus-host disease 5/604 18/7206 0.013892366476 ko04611 Platelet activation 23/604 163/7206 0.0139043075212 ko04068 FoxO signaling pathway 23/604 167/7206 0.0157325380699 ko05323 Rheumatoid arthritis 14/604 89/7206 0.0191069706614 ko04666 Fc gamma R-mediated phagocytosis 18/604 122/7206 0.0191511812987 ko00051 Fructose and mannose metabolism 8/604 42/7206 0.0214371891739 ko04550 Signaling pathways regulating pluripotency of stem cells 6/604 165/7206 0.0223013907538 ko04727 GABAergic synapse 3/604 110/7206 0.0240165376582 ko01212 Fatty acid metabolism 10/604 60/7206 0.0312551898728 ko04916 Melanogenesis 5/604 142/7206 0.0314493824894 ko05152 Tuberculosis 24/604 187/7206 0.0318818275744 ko00380 Tryptophan metabolism 9/604 50/7206 0.0338616785985 ko04012 ErbB signaling pathway 3/604 109/7206 0.0341381960347 ko04072 Phospholipase D signaling pathway 25/604 197/7206 0.0357672109182 ko05224 Breast cancer 7/604 174/7206 0.0364811088028 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/604 4/7206 0.0375469403201 ko00643 Styrene degradation 2/604 4/7206 0.0375469403201 ko04360 Axon guidance 11/604 233/7206 0.0403476273096 ko00920 Sulfur metabolism 3/604 10/7206 0.0450281552113 ko00220 Arginine biosynthesis 5/604 24/7206 0.0454909891656 ko04350 TGF-beta signaling pathway 3/604 103/7206 0.0463675278422 ko05310 Asthma 4/604 17/7206 0.0482957445308