ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	80/741	145/7206	4.46691262782e-42
ko04110	Cell cycle	64/741	145/7206	1.80764823873e-26
ko03030	DNA replication	30/741	38/7206	2.95578048828e-23
ko04111	Cell cycle - yeast	46/741	90/7206	1.2484111453e-22
ko04080	Neuroactive ligand-receptor interaction	2/741	423/7206	5.39006472336e-18
ko03013	RNA transport	54/741	166/7206	2.1450910972e-15
ko03410	Base excision repair	24/741	38/7206	3.28963711402e-15
ko03008	Ribosome biogenesis in eukaryotes	35/741	79/7206	4.94501107982e-15
ko04113	Meiosis - yeast	32/741	70/7206	2.50713940803e-14
ko03460	Fanconi anemia pathway	26/741	51/7206	2.76874842223e-13
ko03430	Mismatch repair	16/741	22/7206	5.54041449269e-12
ko03015	mRNA surveillance pathway	33/741	93/7206	4.96150006925e-11
ko04020	Calcium signaling pathway	2/741	265/7206	1.73694258437e-10
ko04144	Endocytosis	6/741	342/7206	4.06426279214e-10
ko03440	Homologous recombination	19/741	41/7206	3.72760469197e-09
ko03420	Nucleotide excision repair	20/741	46/7206	5.73110457488e-09
ko00240	Pyrimidine metabolism	33/741	110/7206	7.03048382454e-09
ko05217	Basal cell carcinoma	24/741	68/7206	2.50391278494e-08
ko04932	Non-alcoholic fatty liver disease (NAFLD)	1/741	182/7206	8.17122058241e-08
ko04062	Chemokine signaling pathway	3/741	201/7206	1.35937799963e-06
ko04022	cGMP-PKG signaling pathway	4/741	216/7206	1.88598139691e-06
ko04724	Glutamatergic synapse	1/741	152/7206	2.16816706564e-06
ko04024	cAMP signaling pathway	8/741	279/7206	2.80256486281e-06
ko04921	Oxytocin signaling pathway	4/741	209/7206	4.07845364314e-06
ko04725	Cholinergic synapse	2/741	160/7206	8.53404061474e-06
ko04072	Phospholipase D signaling pathway	4/741	197/7206	1.22706082286e-05
ko04723	Retrograde endocannabinoid signaling	3/741	175/7206	1.26208883512e-05
ko04915	Estrogen signaling pathway	1/741	131/7206	1.57578247031e-05
ko03010	Ribosome	1/741	129/7206	2.43915444849e-05
ko05166	HTLV-I infection	52/741	292/7206	6.88703733934e-05
ko04621	NOD-like receptor signaling pathway	3/741	157/7206	8.35640887392e-05
ko04726	Serotonergic synapse	2/741	137/7206	8.69551867608e-05
ko04070	Phosphatidylinositol signaling system	1/741	112/7206	0.000116180459628
ko00230	Purine metabolism	37/741	194/7206	0.000170322201721
ko04727	GABAergic synapse	1/741	110/7206	0.00018093324623
ko04014	Ras signaling pathway	12/741	279/7206	0.000380613460375
ko04060	Cytokine-cytokine receptor interaction	6/741	191/7206	0.000380663869209
ko04270	Vascular smooth muscle contraction	4/741	154/7206	0.000418714743498
ko00670	One carbon pool by folate	8/741	20/7206	0.000491360274096
ko04713	Circadian entrainment	3/741	136/7206	0.00050544812123
ko04911	Insulin secretion	2/741	117/7206	0.000571605649404
ko04260	Cardiac muscle contraction	1/741	98/7206	0.000583420932545
ko04971	Gastric acid secretion	1/741	98/7206	0.000583420932545
ko04970	Salivary secretion	1/741	95/7206	0.00089419222656
ko04371	Apelin signaling pathway	6/741	177/7206	0.000982044798401
ko04261	Adrenergic signaling in cardiomyocytes	8/741	205/7206	0.00100305648426
ko05032	Morphine addiction	2/741	110/7206	0.00123107155282
ko00562	Inositol phosphate metabolism	1/741	89/7206	0.00124152907847
ko04722	Neurotrophin signaling pathway	5/741	160/7206	0.00134402220913
ko04660	T cell receptor signaling pathway	3/741	124/7206	0.00147482075976
ko04218	Cellular senescence	32/741	177/7206	0.00150479195603
ko04550	Signaling pathways regulating pluripotency of stem cells	30/741	165/7206	0.00167612279815
ko04925	Aldosterone synthesis and secretion	2/741	105/7206	0.00173920423097
ko04530	Tight junction	10/741	228/7206	0.0017459658335
ko04340	Hedgehog signaling pathway	14/741	58/7206	0.00178795980275
ko04010	MAPK signaling pathway	17/741	321/7206	0.0017954489479
ko03020	RNA polymerase	9/741	29/7206	0.00184141935494
ko04912	GnRH signaling pathway	3/741	122/7206	0.00219611688812
ko04380	Osteoclast differentiation	4/741	134/7206	0.00232870472207
ko04670	Leukocyte transendothelial migration	5/741	151/7206	0.00253603203946
ko04810	Regulation of actin cytoskeleton	13/741	264/7206	0.00254995302976
ko04138	Autophagy - yeast	1/741	81/7206	0.00270042323103
ko03018	RNA degradation	18/741	84/7206	0.00297384068002
ko04630	Jak-STAT signaling pathway	4/741	132/7206	0.00333867278877
ko05211	Renal cell carcinoma	2/741	96/7206	0.00358185328298
ko04610	Complement and coagulation cascades	1/741	79/7206	0.00417321864952
ko04972	Pancreatic secretion	3/741	111/7206	0.0041847019661
ko05414	Dilated cardiomyopathy	3/741	112/7206	0.00422035430333
ko05222	Small cell lung cancer	18/741	89/7206	0.00430414219072
ko04728	Dopaminergic synapse	8/741	185/7206	0.00450006184321
ko04114	Oocyte meiosis	25/741	139/7206	0.00456122423084
ko04015	Rap1 signaling pathway	15/741	278/7206	0.00459726312607
ko04330	Notch signaling pathway	14/741	62/7206	0.0046423427912
ko04510	Focal adhesion	12/741	240/7206	0.00465204840006
ko04922	Glucagon signaling pathway	4/741	128/7206	0.00466229092765
ko05120	Epithelial cell signaling in Helicobacter pylori infection	2/741	92/7206	0.00515355798978
ko05030	Cocaine addiction	1/741	73/7206	0.00584755384757
ko04659	Th17 cell differentiation	3/741	106/7206	0.00591145372063
ko00010	Glycolysis / Gluconeogenesis	1/741	74/7206	0.00594434332973
ko04012	ErbB signaling pathway	3/741	109/7206	0.00606842781059
ko04666	Fc gamma R-mediated phagocytosis	4/741	122/7206	0.00632671929851
ko04931	Insulin resistance	5/741	137/7206	0.00648805508384
ko05160	Hepatitis C	6/741	153/7206	0.00654047448421
ko04390	Hippo signaling pathway	31/741	188/7206	0.00712538007689
ko04217	Necroptosis	8/741	178/7206	0.00811911166848
ko04071	Sphingolipid signaling pathway	7/741	162/7206	0.00842689601389
ko04611	Platelet activation	7/741	163/7206	0.00849535661488
ko05231	Choline metabolism in cancer	5/741	134/7206	0.00898706188539
ko04933	AGE-RAGE signaling pathway in diabetic complications	5/741	135/7206	0.00914329009693
ko05152	Tuberculosis	9/741	187/7206	0.00995860879001
ko04924	Renin secretion	2/741	86/7206	0.0109189793364
ko04720	Long-term potentiation	3/741	99/7206	0.0116897364627
ko00564	Glycerophospholipid metabolism	3/741	99/7206	0.0116897364627
ko05410	Hypertrophic cardiomyopathy (HCM)	3/741	100/7206	0.0118008121526
ko04620	Toll-like receptor signaling pathway	3/741	100/7206	0.0118008121526
ko04540	Gap junction	5/741	128/7206	0.0120836542191
ko05142	Chagas disease (American trypanosomiasis)	5/741	130/7206	0.0122821375957
ko04976	Bile secretion	2/741	80/7206	0.0151322027014
ko04740	Olfactory transduction	2/741	80/7206	0.0151322027014
ko04066	HIF-1 signaling pathway	5/741	123/7206	0.0164366415042
ko05110	Vibrio cholerae infection	1/741	63/7206	0.0191630968727
ko00561	Glycerolipid metabolism	1/741	63/7206	0.0191630968727
ko04370	VEGF signaling pathway	2/741	77/7206	0.0217747229372
ko04668	TNF signaling pathway	5/741	120/7206	0.0222641922623
ko04914	Progesterone-mediated oocyte maturation	18/741	104/7206	0.0226807333918
ko05031	Amphetamine addiction	3/741	91/7206	0.0228314569469
ko04950	Maturity onset diabetes of the young	7/741	29/7206	0.0245614413353
ko04310	Wnt signaling pathway	28/741	181/7206	0.0252094813701
ko05168	Herpes simplex infection	28/741	182/7206	0.0259912240096
ko04961	Endocrine and other factor-regulated calcium reabsorption	1/741	59/7206	0.0279535821899
ko04514	Cell adhesion molecules (CAMs)	6/741	130/7206	0.0282812248991
ko00514	Other types of O-glycan biosynthesis	7/741	30/7206	0.0292883910941
ko05224	Breast cancer	27/741	174/7206	0.0305203375817
ko05133	Pertussis	3/741	87/7206	0.0317385500522
ko05145	Toxoplasmosis	6/741	126/7206	0.0375877175125
ko05167	Kaposi's sarcoma-associated herpesvirus infection	11/741	191/7206	0.0391054456972
ko04151	PI3K-Akt signaling pathway	28/741	390/7206	0.0392738733235
ko05016	Huntington's disease	13/741	215/7206	0.0393704408904
ko00280	Valine, leucine and isoleucine degradation	1/741	54/7206	0.0397970520269
ko04142	Lysosome	8/741	151/7206	0.0414171594993
ko04974	Protein digestion and absorption	4/741	96/7206	0.0425083681351
ko04064	NF-kappa B signaling pathway	4/741	96/7206	0.0425083681351
ko05100	Bacterial invasion of epithelial cells	4/741	99/7206	0.0433126300505
ko05146	Amoebiasis	4/741	99/7206	0.0433126300505
ko04350	TGF-beta signaling pathway	17/741	103/7206	0.0478127331629