ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	208/1246	423/7206	3.64009211412e-55
ko04724	Glutamatergic synapse	92/1246	152/7206	1.46222116342e-33
ko05033	Nicotine addiction	50/1246	56/7206	3.78021322222e-32
ko05032	Morphine addiction	73/1246	110/7206	1.40513419594e-30
ko04713	Circadian entrainment	79/1246	136/7206	3.16973150877e-27
ko04727	GABAergic synapse	68/1246	110/7206	8.22772118214e-26
ko04728	Dopaminergic synapse	87/1246	185/7206	2.43311705213e-21
ko04725	Cholinergic synapse	79/1246	160/7206	4.00988814543e-21
ko04721	Synaptic vesicle cycle	51/1246	80/7206	1.65175482701e-20
ko04723	Retrograde endocannabinoid signaling	81/1246	175/7206	2.12191984643e-19
ko04020	Calcium signaling pathway	104/1246	265/7206	6.37012964311e-18
ko04024	cAMP signaling pathway	107/1246	279/7206	1.28059796173e-17
ko04911	Insulin secretion	57/1246	117/7206	3.14311013194e-15
ko04726	Serotonergic synapse	63/1246	137/7206	3.5789353951e-15
ko04742	Taste transduction	37/1246	61/7206	3.23586270444e-14
ko04921	Oxytocin signaling pathway	81/1246	209/7206	6.57529079248e-14
ko04744	Phototransduction	26/1246	36/7206	5.23236307479e-13
ko04261	Adrenergic signaling in cardiomyocytes	76/1246	205/7206	6.51171290457e-12
ko05031	Amphetamine addiction	44/1246	91/7206	6.61361634641e-12
ko04720	Long-term potentiation	46/1246	99/7206	1.28210110019e-11
ko04970	Salivary secretion	44/1246	95/7206	4.11114152554e-11
ko03040	Spliceosome	1/1246	145/7206	4.30140398221e-11
ko04360	Axon guidance	77/1246	233/7206	3.01710488753e-09
ko04925	Aldosterone synthesis and secretion	43/1246	105/7206	9.60616274828e-09
ko04740	Olfactory transduction	35/1246	80/7206	2.58117744441e-08
ko05030	Cocaine addiction	32/1246	73/7206	9.67239815119e-08
ko04971	Gastric acid secretion	39/1246	98/7206	1.04491373328e-07
ko05203	Viral carcinogenesis	19/1246	277/7206	3.74393980517e-07
ko03013	RNA transport	7/1246	166/7206	3.78163323232e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1246	74/7206	5.26825578026e-07
ko05168	Herpes simplex infection	9/1246	182/7206	7.41815148578e-07
ko05322	Systemic lupus erythematosus	6/1246	151/7206	1.00124532014e-06
ko04022	cGMP-PKG signaling pathway	66/1246	216/7206	1.43297810644e-06
ko04060	Cytokine-cytokine receptor interaction	11/1246	191/7206	2.4587685905e-06
ko04070	Phosphatidylinositol signaling system	40/1246	112/7206	3.10927669533e-06
ko04010	MAPK signaling pathway	88/1246	321/7206	3.49891529514e-06
ko05164	Influenza A	9/1246	167/7206	6.15616105707e-06
ko04141	Protein processing in endoplasmic reticulum	11/1246	184/7206	6.80219374682e-06
ko04014	Ras signaling pathway	78/1246	279/7206	7.33320140678e-06
ko04540	Gap junction	43/1246	128/7206	8.13867832272e-06
ko04972	Pancreatic secretion	38/1246	111/7206	1.21642975243e-05
ko04745	Phototransduction - fly	18/1246	38/7206	1.72368556127e-05
ko04072	Phospholipase D signaling pathway	58/1246	197/7206	2.09447622572e-05
ko04730	Long-term depression	29/1246	78/7206	2.61827613972e-05
ko04514	Cell adhesion molecules (CAMs)	42/1246	130/7206	2.9791034528e-05
ko04621	NOD-like receptor signaling pathway	10/1246	157/7206	6.83080230755e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1246	79/7206	7.04439650873e-05
ko05414	Dilated cardiomyopathy	36/1246	112/7206	0.00011919276713
ko04966	Collecting duct acid secretion	13/1246	26/7206	0.000129815683881
ko04750	Inflammatory mediator regulation of TRP channels	38/1246	122/7206	0.000148325591474
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1246	59/7206	0.000202159154229
ko04924	Renin secretion	29/1246	86/7206	0.000241861478131
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1246	79/7206	0.000247886216592
ko05110	Vibrio cholerae infection	23/1246	63/7206	0.000283175182552
ko04110	Cell cycle	10/1246	145/7206	0.000342075781065
ko04610	Complement and coagulation cascades	3/1246	79/7206	0.000457899371664
ko04612	Antigen processing and presentation	3/1246	77/7206	0.000677202007179
ko04371	Apelin signaling pathway	48/1246	177/7206	0.000851817094549
ko04976	Bile secretion	26/1246	80/7206	0.000864066324967
ko05162	Measles	8/1246	120/7206	0.000918132977424
ko00240	Pyrimidine metabolism	7/1246	110/7206	0.00129940835302
ko05169	Epstein-Barr virus infection	19/1246	206/7206	0.00137778969418
ko04626	Plant-pathogen interaction	9/1246	18/7206	0.00146301859551
ko04915	Estrogen signaling pathway	37/1246	131/7206	0.00153402549834
ko04146	Peroxisome	5/1246	89/7206	0.00171047159594
ko00330	Arginine and proline metabolism	2/1246	61/7206	0.0017525873097
ko04015	Rap1 signaling pathway	68/1246	278/7206	0.00203018889345
ko04120	Ubiquitin mediated proteolysis	11/1246	138/7206	0.00204942724353
ko04064	NF-kappa B signaling pathway	6/1246	96/7206	0.00248654306896
ko04260	Cardiac muscle contraction	29/1246	98/7206	0.00271385984154
ko03420	Nucleotide excision repair	1/1246	46/7206	0.00279045798635
ko05205	Proteoglycans in cancer	29/1246	271/7206	0.00306951558237
ko05140	Leishmaniasis	4/1246	75/7206	0.00325131900997
ko04270	Vascular smooth muscle contraction	41/1246	154/7206	0.00340798089284
ko00480	Glutathione metabolism	2/1246	55/7206	0.00369574007444
ko03022	Basal transcription factors	1/1246	44/7206	0.0042436549467
ko05144	Malaria	1/1246	45/7206	0.00445504452806
ko00071	Fatty acid degradation	1/1246	45/7206	0.00445504452806
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1246	14/7206	0.00504244419213
ko00590	Arachidonic acid metabolism	2/1246	52/7206	0.00544370710736
ko04923	Regulation of lipolysis in adipocytes	23/1246	77/7206	0.00586676751671
ko04622	RIG-I-like receptor signaling pathway	3/1246	62/7206	0.00621996173654
ko00140	Steroid hormone biosynthesis	1/1246	41/7206	0.00634005026844
ko04657	IL-17 signaling pathway	6/1246	87/7206	0.00655272044077
ko05133	Pertussis	6/1246	87/7206	0.00655272044077
ko04210	Apoptosis	18/1246	180/7206	0.00691740028345
ko04912	GnRH signaling pathway	33/1246	122/7206	0.00737151647638
ko04217	Necroptosis	18/1246	178/7206	0.00883182007562
ko03320	PPAR signaling pathway	4/1246	69/7206	0.00946663266487
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1246	40/7206	0.0099514528805
ko04930	Type II diabetes mellitus	17/1246	54/7206	0.0102012971337
ko00562	Inositol phosphate metabolism	25/1246	89/7206	0.0104782413524
ko04964	Proximal tubule bicarbonate reclamation	11/1246	29/7206	0.01059162148
ko05231	Choline metabolism in cancer	35/1246	134/7206	0.0106139271181
ko00260	Glycine, serine and threonine metabolism	2/1246	48/7206	0.0116829685047
ko05131	Shigellosis	6/1246	82/7206	0.0123486734262
ko03018	RNA degradation	6/1246	84/7206	0.0126404751004
ko05321	Inflammatory bowel disease (IBD)	3/1246	56/7206	0.01268216094
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1246	182/7206	0.012684932404
ko04922	Glucagon signaling pathway	33/1246	128/7206	0.0131774442863
ko04916	Melanogenesis	36/1246	142/7206	0.013425975468
ko05161	Hepatitis B	18/1246	173/7206	0.014244529247
ko00982	Drug metabolism - cytochrome P450	1/1246	37/7206	0.0145390582328
ko03410	Base excision repair	1/1246	38/7206	0.0153159934356
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1246	100/7206	0.015614645559
ko05016	Huntington's disease	24/1246	215/7206	0.0168630381355
ko04214	Apoptosis - fly	5/1246	72/7206	0.0177983954171
ko00280	Valine, leucine and isoleucine degradation	3/1246	54/7206	0.0180606490182
ko00310	Lysine degradation	5/1246	73/7206	0.018247535033
ko04658	Th1 and Th2 cell differentiation	8/1246	96/7206	0.0198911676665
ko04630	Jak-STAT signaling pathway	13/1246	132/7206	0.0199887271301
ko00500	Starch and sucrose metabolism	1/1246	35/7206	0.0221502810469
ko04620	Toll-like receptor signaling pathway	9/1246	100/7206	0.0236337806824
ko04918	Thyroid hormone synthesis	23/1246	86/7206	0.0299658398082
ko04114	Oocyte meiosis	34/1246	139/7206	0.0307214455805
ko05132	Salmonella infection	9/1246	98/7206	0.0310205247764
ko00380	Tryptophan metabolism	3/1246	50/7206	0.036791206844
ko00983	Drug metabolism - other enzymes	2/1246	42/7206	0.0374113123707
ko04710	Circadian rhythm	13/1246	43/7206	0.0397317597757
ko05145	Toxoplasmosis	13/1246	126/7206	0.0423087252813
ko04115	p53 signaling pathway	6/1246	74/7206	0.0427103296597
ko04213	Longevity regulating pathway - multiple species	22/1246	86/7206	0.0450429342539
ko04640	Hematopoietic cell lineage	5/1246	64/7206	0.0453585401095
ko05166	HTLV-I infection	38/1246	292/7206	0.0483157679732
ko05340	Primary immunodeficiency	1/1246	30/7206	0.0490171612345