ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	180/1056	423/7206	3.00891015601e-47
ko04724	Glutamatergic synapse	83/1056	152/7206	2.94418578353e-31
ko05033	Nicotine addiction	47/1056	56/7206	5.169291614e-31
ko05032	Morphine addiction	65/1056	110/7206	2.33506221473e-27
ko04727	GABAergic synapse	64/1056	110/7206	2.04046383099e-26
ko04713	Circadian entrainment	71/1056	136/7206	2.88429937571e-25
ko04728	Dopaminergic synapse	84/1056	185/7206	2.54493289714e-24
ko04725	Cholinergic synapse	75/1056	160/7206	7.29857457278e-23
ko04723	Retrograde endocannabinoid signaling	77/1056	175/7206	2.52450813079e-21
ko04721	Synaptic vesicle cycle	48/1056	80/7206	6.9045219395e-21
ko04024	cAMP signaling pathway	97/1056	279/7206	9.51421254003e-18
ko04911	Insulin secretion	53/1056	117/7206	1.10129597645e-15
ko04726	Serotonergic synapse	58/1056	137/7206	2.12702830603e-15
ko04921	Oxytocin signaling pathway	75/1056	209/7206	1.03776538591e-14
ko04020	Calcium signaling pathway	87/1056	265/7206	2.72053896895e-14
ko04744	Phototransduction	25/1056	36/7206	1.29556190808e-13
ko04261	Adrenergic signaling in cardiomyocytes	71/1056	205/7206	5.03657641286e-13
ko04742	Taste transduction	33/1056	61/7206	5.76497143298e-13
ko04720	Long-term potentiation	43/1056	99/7206	3.38819627593e-12
ko05031	Amphetamine addiction	40/1056	91/7206	1.23015954698e-11
ko04970	Salivary secretion	39/1056	95/7206	2.74264321368e-10
ko03040	Spliceosome	1/1056	145/7206	3.51694901781e-09
ko04971	Gastric acid secretion	37/1056	98/7206	1.22323833418e-08
ko04925	Aldosterone synthesis and secretion	38/1056	105/7206	2.98768865393e-08
ko05168	Herpes simplex infection	5/1056	182/7206	1.07318832472e-07
ko05203	Viral carcinogenesis	13/1056	277/7206	1.30331936623e-07
ko04010	MAPK signaling pathway	82/1056	321/7206	1.67759950068e-07
ko04360	Axon guidance	64/1056	233/7206	2.38748012159e-07
ko04740	Olfactory transduction	30/1056	80/7206	3.50323394886e-07
ko04060	Cytokine-cytokine receptor interaction	7/1056	191/7206	1.15430819107e-06
ko05030	Cocaine addiction	27/1056	73/7206	1.84424889468e-06
ko04972	Pancreatic secretion	36/1056	111/7206	1.92489793836e-06
ko04070	Phosphatidylinositol signaling system	36/1056	112/7206	2.27853492164e-06
ko04730	Long-term depression	28/1056	78/7206	2.3796620826e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1056	79/7206	3.17952032506e-06
ko04022	cGMP-PKG signaling pathway	57/1056	216/7206	5.12577016696e-06
ko05322	Systemic lupus erythematosus	5/1056	151/7206	6.79889332221e-06
ko04260	Cardiac muscle contraction	31/1056	98/7206	1.71350636567e-05
ko04621	NOD-like receptor signaling pathway	6/1056	157/7206	1.7208120598e-05
ko03013	RNA transport	7/1056	166/7206	1.90067091947e-05
ko04966	Collecting duct acid secretion	13/1056	26/7206	2.16032265716e-05
ko04141	Protein processing in endoplasmic reticulum	9/1056	184/7206	3.10380760951e-05
ko04072	Phospholipase D signaling pathway	51/1056	197/7206	3.4269100211e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1056	74/7206	3.50627976356e-05
ko04745	Phototransduction - fly	16/1056	38/7206	3.71278994368e-05
ko04120	Ubiquitin mediated proteolysis	5/1056	138/7206	4.36403679794e-05
ko05414	Dilated cardiomyopathy	33/1056	112/7206	6.32255963818e-05
ko04540	Gap junction	36/1056	128/7206	6.86775198921e-05
ko05164	Influenza A	8/1056	167/7206	8.40966026193e-05
ko04612	Antigen processing and presentation	1/1056	77/7206	0.000125897645791
ko04514	Cell adhesion molecules (CAMs)	35/1056	130/7206	0.000230623369949
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1056	59/7206	0.000246653331344
ko04915	Estrogen signaling pathway	35/1056	131/7206	0.000255199239971
ko05169	Epstein-Barr virus infection	13/1056	206/7206	0.000279484781705
ko04110	Cell cycle	7/1056	145/7206	0.000304946799637
ko04014	Ras signaling pathway	63/1056	279/7206	0.000363379288823
ko04976	Bile secretion	24/1056	80/7206	0.000364062981654
ko05110	Vibrio cholerae infection	20/1056	63/7206	0.000484188767132
ko04924	Renin secretion	25/1056	86/7206	0.000554552670424
ko03008	Ribosome biogenesis in eukaryotes	2/1056	79/7206	0.000626349487176
ko04750	Inflammatory mediator regulation of TRP channels	32/1056	122/7206	0.000689297965652
ko04964	Proximal tubule bicarbonate reclamation	11/1056	29/7206	0.00173542853083
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1056	14/7206	0.00189829581065
ko04064	NF-kappa B signaling pathway	4/1056	96/7206	0.00192617715045
ko05205	Proteoglycans in cancer	23/1056	271/7206	0.00277098897966
ko00480	Glutathione metabolism	1/1056	55/7206	0.0032814901352
ko04146	Peroxisome	4/1056	89/7206	0.00374000793923
ko05162	Measles	7/1056	120/7206	0.00385963060133
ko00240	Pyrimidine metabolism	6/1056	110/7206	0.00393724281091
ko04912	GnRH signaling pathway	30/1056	122/7206	0.00405188682186
ko04640	Hematopoietic cell lineage	2/1056	64/7206	0.00423461536024
ko00590	Arachidonic acid metabolism	1/1056	52/7206	0.00486814440672
ko05140	Leishmaniasis	3/1056	75/7206	0.00487863140495
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1056	182/7206	0.00553116942501
ko00562	Inositol phosphate metabolism	23/1056	89/7206	0.00585221336817
ko04330	Notch signaling pathway	2/1056	62/7206	0.00615483831919
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1056	100/7206	0.00617841163963
ko04973	Carbohydrate digestion and absorption	13/1056	42/7206	0.00673328746441
ko04371	Apelin signaling pathway	39/1056	177/7206	0.00698064027848
ko00310	Lysine degradation	3/1056	73/7206	0.00701281790795
ko00260	Glycine, serine and threonine metabolism	1/1056	48/7206	0.00715296858356
ko04350	TGF-beta signaling pathway	6/1056	103/7206	0.0073523268212
ko04062	Chemokine signaling pathway	43/1056	201/7206	0.00836879980512
ko04626	Plant-pathogen interaction	7/1056	18/7206	0.0103246647703
ko05144	Malaria	1/1056	45/7206	0.0106660937109
ko00071	Fatty acid degradation	1/1056	45/7206	0.0106660937109
ko03420	Nucleotide excision repair	1/1056	46/7206	0.0107133278747
ko05166	HTLV-I infection	28/1056	292/7206	0.0110971252471
ko05161	Hepatitis B	14/1056	173/7206	0.0119245454855
ko05321	Inflammatory bowel disease (IBD)	2/1056	56/7206	0.0129238463892
ko04140	Autophagy - animal	13/1056	164/7206	0.0134101681288
ko05231	Choline metabolism in cancer	30/1056	134/7206	0.0136105338973
ko04657	IL-17 signaling pathway	5/1056	87/7206	0.0141677775875
ko05214	Glioma	20/1056	79/7206	0.0149896961771
ko03022	Basal transcription factors	1/1056	44/7206	0.0162977911291
ko04217	Necroptosis	15/1056	178/7206	0.0176171946386
ko04658	Th1 and Th2 cell differentiation	6/1056	96/7206	0.0188927676773
ko03018	RNA degradation	5/1056	84/7206	0.0194045699059
ko04012	ErbB signaling pathway	25/1056	109/7206	0.0195013953175
ko04115	p53 signaling pathway	4/1056	74/7206	0.0199513499044
ko01524	Platinum drug resistance	4/1056	76/7206	0.0207321961885
ko04923	Regulation of lipolysis in adipocytes	19/1056	77/7206	0.0215627346116
ko05418	Fluid shear stress and atherosclerosis	15/1056	173/7206	0.0220697015125
ko04722	Neurotrophin signaling pathway	34/1056	160/7206	0.0230754714834
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1056	40/7206	0.0235240290285
ko00140	Steroid hormone biosynthesis	1/1056	41/7206	0.0240153879306
ko04015	Rap1 signaling pathway	54/1056	278/7206	0.0245389571555
ko04214	Apoptosis - fly	4/1056	72/7206	0.0278863071509
ko00330	Arginine and proline metabolism	3/1056	61/7206	0.0279515048615
ko04622	RIG-I-like receptor signaling pathway	3/1056	62/7206	0.0284158222235
ko05145	Toxoplasmosis	10/1056	126/7206	0.0302030591546
ko04918	Thyroid hormone synthesis	20/1056	86/7206	0.0306874788541
ko04930	Type II diabetes mellitus	14/1056	54/7206	0.0307412303251
ko04916	Melanogenesis	30/1056	142/7206	0.0311731478358
ko05222	Small cell lung cancer	6/1056	89/7206	0.0336278710583
ko00982	Drug metabolism - cytochrome P450	1/1056	37/7206	0.034795557292
ko04630	Jak-STAT signaling pathway	11/1056	132/7206	0.0349044786751
ko04270	Vascular smooth muscle contraction	32/1056	154/7206	0.0373679629136
ko03320	PPAR signaling pathway	4/1056	69/7206	0.0383422223978
ko05016	Huntington's disease	21/1056	215/7206	0.0395397182282
ko04960	Aldosterone-regulated sodium reabsorption	11/1056	41/7206	0.0420769639162
ko04071	Sphingolipid signaling pathway	33/1056	162/7206	0.0428164687603
ko05133	Pertussis	6/1056	87/7206	0.0455581766087
ko05034	Alcoholism	46/1056	238/7206	0.0496079287162