ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 125/738 423/7206 1.56964217795e-30 ko04724 Glutamatergic synapse 59/738 152/7206 4.08361245887e-21 ko05033 Nicotine addiction 33/738 56/7206 3.60771184753e-19 ko04713 Circadian entrainment 48/738 136/7206 1.91523757907e-15 ko04727 GABAergic synapse 40/738 110/7206 1.45303972983e-13 ko05032 Morphine addiction 39/738 110/7206 7.56261858834e-13 ko04721 Synaptic vesicle cycle 32/738 80/7206 2.06004227888e-12 ko04725 Cholinergic synapse 48/738 160/7206 2.10105107871e-12 ko04728 Dopaminergic synapse 52/738 185/7206 4.09415541371e-12 ko04723 Retrograde endocannabinoid signaling 49/738 175/7206 2.03849113915e-11 ko04020 Calcium signaling pathway 64/738 265/7206 2.82911036971e-11 ko04024 cAMP signaling pathway 66/738 279/7206 2.90071411823e-11 ko04911 Insulin secretion 38/738 117/7206 3.20344413901e-11 ko05031 Amphetamine addiction 31/738 91/7206 5.64899402979e-10 ko04720 Long-term potentiation 32/738 99/7206 1.35728350213e-09 ko04921 Oxytocin signaling pathway 51/738 209/7206 1.86804961853e-09 ko04726 Serotonergic synapse 38/738 137/7206 5.20460764504e-09 ko04970 Salivary secretion 30/738 95/7206 8.28569307577e-09 ko04925 Aldosterone synthesis and secretion 29/738 105/7206 3.82956338667e-07 ko04070 Phosphatidylinositol signaling system 29/738 112/7206 1.657466975e-06 ko04022 cGMP-PKG signaling pathway 45/738 216/7206 3.13849377071e-06 ko04261 Adrenergic signaling in cardiomyocytes 43/738 205/7206 3.43472416108e-06 ko04971 Gastric acid secretion 26/738 98/7206 3.49904499173e-06 ko03040 Spliceosome 1/738 145/7206 4.90528684231e-06 ko04730 Long-term depression 22/738 78/7206 6.70914560346e-06 ko05030 Cocaine addiction 21/738 73/7206 7.72153346051e-06 ko04745 Phototransduction - fly 14/738 38/7206 1.14380924903e-05 ko03010 Ribosome 1/738 129/7206 2.40930077279e-05 ko04742 Taste transduction 17/738 61/7206 8.76302404101e-05 ko04972 Pancreatic secretion 25/738 111/7206 0.000113602692252 ko05014 Amyotrophic lateral sclerosis (ALS) 19/738 74/7206 0.000115782015885 ko05322 Systemic lupus erythematosus 3/738 151/7206 0.000117564445135 ko05203 Viral carcinogenesis 11/738 277/7206 0.000158216006609 ko04626 Plant-pathogen interaction 8/738 18/7206 0.000200022691787 ko03013 RNA transport 4/738 166/7206 0.000220244877216 ko04750 Inflammatory mediator regulation of TRP channels 26/738 122/7206 0.000232180510628 ko04710 Circadian rhythm 13/738 43/7206 0.000242834267275 ko04514 Cell adhesion molecules (CAMs) 27/738 130/7206 0.000335833525482 ko04540 Gap junction 26/738 128/7206 0.000567449393396 ko05168 Herpes simplex infection 6/738 182/7206 0.000713124401726 ko04924 Renin secretion 19/738 86/7206 0.000993335246855 ko05169 Epstein-Barr virus infection 8/738 206/7206 0.00100517701468 ko04010 MAPK signaling pathway 51/738 321/7206 0.00127712336577 ko05110 Vibrio cholerae infection 15/738 63/7206 0.00138385351692 ko04014 Ras signaling pathway 45/738 279/7206 0.00171416806266 ko04964 Proximal tubule bicarbonate reclamation 9/738 29/7206 0.00178942292519 ko04360 Axon guidance 39/738 233/7206 0.00191915962834 ko05162 Measles 3/738 120/7206 0.00209214478977 ko04960 Aldosterone-regulated sodium reabsorption 11/738 41/7206 0.00214452484234 ko05164 Influenza A 6/738 167/7206 0.00263135158156 ko04922 Glucagon signaling pathway 24/738 128/7206 0.00294784417948 ko04966 Collecting duct acid secretion 8/738 26/7206 0.003399115901 ko04110 Cell cycle 5/738 145/7206 0.00342328767519 ko04612 Antigen processing and presentation 1/738 77/7206 0.00397265622879 ko04072 Phospholipase D signaling pathway 33/738 197/7206 0.00399607225038 ko00680 Methane metabolism 9/738 34/7206 0.00588006759822 ko04141 Protein processing in endoplasmic reticulum 8/738 184/7206 0.00620550381007 ko04260 Cardiac muscle contraction 19/738 98/7206 0.00621713792391 ko04918 Thyroid hormone synthesis 17/738 86/7206 0.00660718431529 ko04711 Circadian rhythm - fly 5/738 13/7206 0.0070972282938 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/738 59/7206 0.00742909864693 ko04740 Olfactory transduction 16/738 80/7206 0.00807987884395 ko04630 Jak-STAT signaling pathway 5/738 132/7206 0.00887267209302 ko04114 Oocyte meiosis 24/738 139/7206 0.0101672993032 ko04621 NOD-like receptor signaling pathway 7/738 157/7206 0.0112681873971 ko04916 Melanogenesis 24/738 142/7206 0.011670088062 ko00562 Inositol phosphate metabolism 16/738 89/7206 0.0214937431009 ko05130 Pathogenic Escherichia coli infection 2/738 77/7206 0.0217116778556 ko05166 HTLV-I infection 19/738 292/7206 0.0299456970112 ko04270 Vascular smooth muscle contraction 24/738 154/7206 0.03160877761 ko05010 Alzheimer's disease 30/738 202/7206 0.0337233443841 ko04932 Non-alcoholic fatty liver disease (NAFLD) 10/738 182/7206 0.0341930419756 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/738 79/7206 0.0378374665878 ko04810 Regulation of actin cytoskeleton 17/738 264/7206 0.0381129081626 ko04060 Cytokine-cytokine receptor interaction 11/738 191/7206 0.0389688290743 ko04510 Focal adhesion 15/738 240/7206 0.0390023222203 ko05016 Huntington's disease 13/738 215/7206 0.0392712310123 ko04015 Rap1 signaling pathway 39/738 278/7206 0.0428070830862 ko04217 Necroptosis 10/738 178/7206 0.0439035454476 ko05220 Chronic myeloid leukemia 3/738 85/7206 0.0449505511943 ko04120 Ubiquitin mediated proteolysis 7/738 138/7206 0.0458130283933 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/738 14/7206 0.047411884283