ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	108/968	145/7206	1.21425567942e-64
ko03013	RNA transport	80/968	166/7206	5.91380300014e-28
ko04080	Neuroactive ligand-receptor interaction	1/968	423/7206	4.71504108739e-26
ko04110	Cell cycle	71/968	145/7206	1.96313556227e-25
ko03008	Ribosome biogenesis in eukaryotes	49/968	79/7206	6.38015292478e-24
ko03030	DNA replication	31/968	38/7206	3.02489694035e-21
ko03440	Homologous recombination	32/968	41/7206	8.36626821228e-21
ko03460	Fanconi anemia pathway	36/968	51/7206	9.74914566605e-21
ko04111	Cell cycle - yeast	49/968	90/7206	1.90599147402e-20
ko03420	Nucleotide excision repair	30/968	46/7206	5.3852342456e-16
ko03022	Basal transcription factors	29/968	44/7206	1.09322837978e-15
ko03050	Proteasome	32/968	54/7206	3.21228438641e-15
ko04113	Meiosis - yeast	35/968	70/7206	1.76142926572e-13
ko04144	Endocytosis	8/968	342/7206	4.46056074841e-13
ko00240	Pyrimidine metabolism	45/968	110/7206	5.90727499443e-13
ko03430	Mismatch repair	18/968	22/7206	7.57460780685e-13
ko03018	RNA degradation	38/968	84/7206	8.97830168476e-13
ko03410	Base excision repair	24/968	38/7206	1.36168537344e-12
ko05010	Alzheimer's disease	2/968	202/7206	1.60224866767e-10
ko03015	mRNA surveillance pathway	37/968	93/7206	1.83337007081e-10
ko04024	cAMP signaling pathway	7/968	279/7206	2.49299255395e-10
ko03020	RNA polymerase	18/968	29/7206	1.40729865904e-09
ko05169	Epstein-Barr virus infection	60/968	206/7206	2.1733194239e-09
ko04723	Retrograde endocannabinoid signaling	3/968	175/7206	5.90342597183e-08
ko04060	Cytokine-cytokine receptor interaction	4/968	191/7206	6.36248197932e-08
ko04022	cGMP-PKG signaling pathway	6/968	216/7206	7.88336287429e-08
ko04724	Glutamatergic synapse	2/968	152/7206	1.12039692978e-07
ko04932	Non-alcoholic fatty liver disease (NAFLD)	4/968	182/7206	2.05296493175e-07
ko04514	Cell adhesion molecules (CAMs)	1/968	130/7206	3.11229174527e-07
ko04270	Vascular smooth muscle contraction	3/968	154/7206	9.43051440118e-07
ko04510	Focal adhesion	10/968	240/7206	1.79734942943e-06
ko04261	Adrenergic signaling in cardiomyocytes	7/968	205/7206	1.89972674696e-06
ko04530	Tight junction	9/968	228/7206	2.42221223956e-06
ko04014	Ras signaling pathway	14/968	279/7206	4.00288903943e-06
ko05012	Parkinson's disease	4/968	155/7206	4.14450032508e-06
ko04921	Oxytocin signaling pathway	8/968	209/7206	4.22349606527e-06
ko04621	NOD-like receptor signaling pathway	4/968	157/7206	4.26119564014e-06
ko04010	MAPK signaling pathway	18/968	321/7206	5.08243830223e-06
ko04810	Regulation of actin cytoskeleton	13/968	264/7206	5.48265055082e-06
ko04713	Circadian entrainment	3/968	136/7206	9.76862363139e-06
ko04062	Chemokine signaling pathway	8/968	201/7206	1.23582271738e-05
ko04911	Insulin secretion	2/968	117/7206	1.39055228761e-05
ko00230	Purine metabolism	48/968	194/7206	1.54677460183e-05
ko04725	Cholinergic synapse	5/968	160/7206	1.66901786378e-05
ko04971	Gastric acid secretion	1/968	98/7206	1.77456815411e-05
ko05146	Amoebiasis	1/968	99/7206	1.81488135033e-05
ko04120	Ubiquitin mediated proteolysis	37/968	138/7206	2.25396096219e-05
ko04727	GABAergic synapse	2/968	110/7206	3.03340298735e-05
ko04070	Phosphatidylinositol signaling system	2/968	112/7206	3.17744113387e-05
ko04611	Platelet activation	6/968	163/7206	3.80096677823e-05
ko05152	Tuberculosis	8/968	187/7206	4.59967598856e-05
ko04151	PI3K-Akt signaling pathway	27/968	390/7206	4.61432293327e-05
ko04728	Dopaminergic synapse	8/968	185/7206	6.60864943789e-05
ko04659	Th17 cell differentiation	2/968	106/7206	6.98011718103e-05
ko04915	Estrogen signaling pathway	4/968	131/7206	8.08164159863e-05
ko04630	Jak-STAT signaling pathway	4/968	132/7206	8.21523039403e-05
ko04015	Rap1 signaling pathway	17/968	278/7206	0.000101196184851
ko05142	Chagas disease (American trypanosomiasis)	4/968	130/7206	0.000123009781764
ko04371	Apelin signaling pathway	8/968	177/7206	0.000123572344567
ko00564	Glycerophospholipid metabolism	2/968	99/7206	0.000146948946022
ko04670	Leukocyte transendothelial migration	6/968	151/7206	0.000152223349892
ko05145	Toxoplasmosis	4/968	126/7206	0.00017074037077
ko04072	Phospholipase D signaling pathway	10/968	197/7206	0.000177555612314
ko04726	Serotonergic synapse	5/968	137/7206	0.000195269784711
ko05032	Morphine addiction	3/968	110/7206	0.000195808272003
ko04972	Pancreatic secretion	3/968	111/7206	0.000198972494265
ko04976	Bile secretion	1/968	80/7206	0.000205111853978
ko04740	Olfactory transduction	1/968	80/7206	0.000205111853978
ko04380	Osteoclast differentiation	5/968	134/7206	0.00027749238738
ko05120	Epithelial cell signaling in Helicobacter pylori infection	2/968	92/7206	0.000314335565537
ko04668	TNF signaling pathway	4/968	120/7206	0.000352462784443
ko04925	Aldosterone synthesis and secretion	3/968	105/7206	0.000419603704366
ko05160	Hepatitis C	7/968	153/7206	0.000441752102331
ko00562	Inositol phosphate metabolism	2/968	89/7206	0.000461981651538
ko05140	Leishmaniasis	1/968	75/7206	0.000470691413359
ko04922	Glucagon signaling pathway	5/968	128/7206	0.000557199250085
ko04620	Toll-like receptor signaling pathway	3/968	100/7206	0.000594909504045
ko05200	Pathways in cancer	42/968	492/7206	0.000602209955136
ko04924	Renin secretion	2/968	86/7206	0.000677968203334
ko04933	AGE-RAGE signaling pathway in diabetic complications	6/968	135/7206	0.000819081406117
ko04360	Axon guidance	15/968	233/7206	0.000825625427898
ko04931	Insulin resistance	6/968	137/7206	0.000849526036241
ko04650	Natural killer cell mediated cytotoxicity	3/968	97/7206	0.000857261812547
ko04912	GnRH signaling pathway	5/968	122/7206	0.00110965355472
ko04750	Inflammatory mediator regulation of TRP channels	5/968	122/7206	0.00110965355472
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	2/968	79/7206	0.00145430061791
ko04512	ECM-receptor interaction	2/968	79/7206	0.00145430061791
ko05031	Amphetamine addiction	3/968	91/7206	0.00176973267182
ko03450	Non-homologous end-joining	7/968	15/7206	0.00185965282966
ko03060	Protein export	9/968	23/7206	0.00191683739652
ko05166	HTLV-I infection	58/968	292/7206	0.0020440734265
ko04923	Regulation of lipolysis in adipocytes	2/968	77/7206	0.0021219290263
ko04114	Oocyte meiosis	32/968	139/7206	0.00227802029728
ko04662	B cell receptor signaling pathway	3/968	88/7206	0.00253482936862
ko05168	Herpes simplex infection	39/968	182/7206	0.00271934293989
ko05231	Choline metabolism in cancer	7/968	134/7206	0.00299951758143
ko04066	HIF-1 signaling pathway	6/968	123/7206	0.00302935906558
ko05030	Cocaine addiction	2/968	73/7206	0.00308469736851
ko05203	Viral carcinogenesis	54/968	277/7206	0.00390176585859
ko04218	Cellular senescence	37/968	177/7206	0.00504159910811
ko04660	T cell receptor signaling pathway	7/968	124/7206	0.00748108895493
ko04138	Autophagy - yeast	3/968	81/7206	0.00767345476588
ko04930	Type II diabetes mellitus	1/968	54/7206	0.00774770859781
ko00280	Valine, leucine and isoleucine degradation	1/968	54/7206	0.00774770859781
ko04068	FoxO signaling pathway	11/968	167/7206	0.00778057145555
ko04712	Circadian rhythm - plant	4/968	7/7206	0.00808470081368
ko04910	Insulin signaling pathway	12/968	172/7206	0.00908360516493
ko05167	Kaposi's sarcoma-associated herpesvirus infection	14/968	191/7206	0.0096593255937
ko04666	Fc gamma R-mediated phagocytosis	7/968	122/7206	0.0102291972436
ko05132	Salmonella infection	5/968	98/7206	0.0108008714147
ko05133	Pertussis	4/968	87/7206	0.0108084646997
ko04142	Lysosome	10/968	151/7206	0.0108732304741
ko04720	Long-term potentiation	5/968	99/7206	0.0108756410875
ko04730	Long-term depression	3/968	78/7206	0.0109115669797
ko04146	Peroxisome	4/968	89/7206	0.0111764047932
ko00670	One carbon pool by folate	7/968	20/7206	0.0122159302611
ko01200	Carbon metabolism	8/968	128/7206	0.012664624487
ko04540	Gap junction	8/968	128/7206	0.012664624487
ko04722	Neurotrophin signaling pathway	11/968	160/7206	0.0131687082972
ko04914	Progesterone-mediated oocyte maturation	23/968	104/7206	0.0131967101403
ko04622	RIG-I-like receptor signaling pathway	2/968	62/7206	0.0136638939018
ko05205	Proteoglycans in cancer	23/968	271/7206	0.0139190879803
ko05211	Renal cell carcinoma	5/968	96/7206	0.0149430750722
ko00010	Glycolysis / Gluconeogenesis	3/968	74/7206	0.0149897100641
ko00620	Pyruvate metabolism	1/968	46/7206	0.0165615218439
ko05204	Chemical carcinogenesis	1/968	48/7206	0.0170485490306
ko04071	Sphingolipid signaling pathway	12/968	162/7206	0.019642280572
ko04145	Phagosome	12/968	162/7206	0.019642280572
ko05230	Central carbon metabolism in cancer	4/968	81/7206	0.0208167792909
ko04330	Notch signaling pathway	15/968	62/7206	0.0223424624543
ko04130	SNARE interactions in vesicular transport	1/968	44/7206	0.0245854220419
ko04216	Ferroptosis	1/968	44/7206	0.0245854220419
ko04370	VEGF signaling pathway	4/968	77/7206	0.028601235238
ko05164	Influenza A	13/968	167/7206	0.0287634553226
ko04012	ErbB signaling pathway	7/968	109/7206	0.0323970964368
ko04658	Th1 and Th2 cell differentiation	6/968	96/7206	0.034635950925
ko00980	Metabolism of xenobiotics by cytochrome P450	1/968	40/7206	0.0360323290309
ko00830	Retinol metabolism	1/968	42/7206	0.037246910541
ko00565	Ether lipid metabolism	1/968	42/7206	0.037246910541
ko04213	Longevity regulating pathway - multiple species	5/968	86/7206	0.0373473123665
ko04918	Thyroid hormone synthesis	5/968	86/7206	0.0373473123665
ko04657	IL-17 signaling pathway	5/968	87/7206	0.037883540803
ko05322	Systemic lupus erythematosus	29/968	151/7206	0.0402302676317
ko04913	Ovarian steroidogenesis	3/968	63/7206	0.0404111210711
ko00561	Glycerolipid metabolism	3/968	63/7206	0.0404111210711
ko00600	Sphingolipid metabolism	3/968	63/7206	0.0404111210711
ko00970	Aminoacyl-tRNA biosynthesis	11/968	44/7206	0.0412915756909
ko04916	Melanogenesis	11/968	142/7206	0.0460746903833
ko04152	AMPK signaling pathway	13/968	161/7206	0.0461672085272