ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 37/488 152/7206 3.2303506267e-12 ko04020 Calcium signaling pathway 49/488 265/7206 5.09647323493e-11 ko04080 Neuroactive ligand-receptor interaction 62/488 423/7206 3.2193774952e-09 ko05032 Morphine addiction 26/488 110/7206 1.15490438668e-08 ko04713 Circadian entrainment 29/488 136/7206 2.00373326747e-08 ko04725 Cholinergic synapse 31/488 160/7206 6.88603216526e-08 ko04728 Dopaminergic synapse 33/488 185/7206 2.03256557478e-07 ko04070 Phosphatidylinositol signaling system 24/488 112/7206 3.09610809589e-07 ko04925 Aldosterone synthesis and secretion 23/488 105/7206 3.60550514484e-07 ko04921 Oxytocin signaling pathway 35/488 209/7206 4.25383596281e-07 ko04720 Long-term potentiation 22/488 99/7206 4.98402936055e-07 ko04727 GABAergic synapse 23/488 110/7206 8.67347548345e-07 ko04726 Serotonergic synapse 25/488 137/7206 4.10324076523e-06 ko04024 cAMP signaling pathway 39/488 279/7206 1.35720785205e-05 ko05033 Nicotine addiction 14/488 56/7206 1.4604504037e-05 ko04723 Retrograde endocannabinoid signaling 28/488 175/7206 1.91988836547e-05 ko04060 Cytokine-cytokine receptor interaction 1/488 191/7206 3.03280881119e-05 ko04911 Insulin secretion 21/488 117/7206 3.13705091613e-05 ko04922 Glucagon signaling pathway 22/488 128/7206 4.0937714347e-05 ko04721 Synaptic vesicle cycle 16/488 80/7206 7.19151852161e-05 ko04710 Circadian rhythm 11/488 43/7206 9.67475623247e-05 ko05031 Amphetamine addiction 17/488 91/7206 0.000105775836851 ko04745 Phototransduction - fly 10/488 38/7206 0.000155474685253 ko04970 Salivary secretion 17/488 95/7206 0.000183350810516 ko04730 Long-term depression 15/488 78/7206 0.000191095877505 ko00680 Methane metabolism 9/488 34/7206 0.000316460979678 ko00010 Glycolysis / Gluconeogenesis 14/488 74/7206 0.000370968591271 ko05322 Systemic lupus erythematosus 1/488 151/7206 0.000462045908886 ko04742 Taste transduction 12/488 61/7206 0.00066676762207 ko03040 Spliceosome 1/488 145/7206 0.000678816738972 ko04750 Inflammatory mediator regulation of TRP channels 19/488 122/7206 0.000682661490653 ko04971 Gastric acid secretion 16/488 98/7206 0.000814119739968 ko04740 Olfactory transduction 14/488 80/7206 0.000843417149308 ko04072 Phospholipase D signaling pathway 26/488 197/7206 0.000844380998073 ko04626 Plant-pathogen interaction 6/488 18/7206 0.000860310801682 ko04261 Adrenergic signaling in cardiomyocytes 27/488 205/7206 0.000944269261841 ko04371 Apelin signaling pathway 24/488 177/7206 0.00114824312233 ko04022 cGMP-PKG signaling pathway 27/488 216/7206 0.00211412978687 ko05203 Viral carcinogenesis 7/488 277/7206 0.00212032769219 ko03010 Ribosome 1/488 129/7206 0.00216023622498 ko05168 Herpes simplex infection 3/488 182/7206 0.00243439863926 ko00562 Inositol phosphate metabolism 14/488 89/7206 0.0024368430486 ko04930 Type II diabetes mellitus 10/488 54/7206 0.00295988726598 ko04912 GnRH signaling pathway 17/488 122/7206 0.00514637909629 ko00051 Fructose and mannose metabolism 8/488 42/7206 0.00636551121984 ko04966 Collecting duct acid secretion 6/488 26/7206 0.00671394879903 ko04014 Ras signaling pathway 31/488 279/7206 0.0069347402226 ko04114 Oocyte meiosis 18/488 139/7206 0.00909580462178 ko04972 Pancreatic secretion 15/488 111/7206 0.0111675485046 ko05230 Central carbon metabolism in cancer 12/488 81/7206 0.0112017165679 ko00512 Mucin type O-glycan biosynthesis 6/488 29/7206 0.0116603951478 ko05224 Breast cancer 4/488 174/7206 0.0135464332722 ko01230 Biosynthesis of amino acids 12/488 85/7206 0.0139919467974 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 4/488 15/7206 0.015567643264 ko05162 Measles 2/488 120/7206 0.0167922729686 ko00510 N-Glycan biosynthesis 8/488 50/7206 0.0180424302124 ko04110 Cell cycle 3/488 145/7206 0.0181736031669 ko04550 Signaling pathways regulating pluripotency of stem cells 4/488 165/7206 0.0183523179176 ko04923 Regulation of lipolysis in adipocytes 11/488 77/7206 0.0183699367454 ko00513 Various types of N-glycan biosynthesis 7/488 42/7206 0.0213238350525 ko04974 Protein digestion and absorption 1/488 96/7206 0.0214293835237 ko00564 Glycerophospholipid metabolism 13/488 99/7206 0.0232373492179 ko05169 Epstein-Barr virus infection 6/488 206/7206 0.0232719578698 ko00515 Mannose type O-glycan biosynthesis 5/488 25/7206 0.023953346003 ko04150 mTOR signaling pathway 5/488 184/7206 0.0244970392124 ko00471 D-Glutamine and D-glutamate metabolism 2/488 4/7206 0.0250564510337 ko04510 Focal adhesion 8/488 240/7206 0.0262422623807 ko04657 IL-17 signaling pathway 1/488 87/7206 0.029697467226 ko04010 MAPK signaling pathway 32/488 321/7206 0.0298157142446 ko04540 Gap junction 15/488 128/7206 0.032116839903 ko05160 Hepatitis C 4/488 153/7206 0.033900803847 ko04512 ECM-receptor interaction 1/488 79/7206 0.0426618744982 ko04810 Regulation of actin cytoskeleton 10/488 264/7206 0.0460072439569 ko04350 TGF-beta signaling pathway 2/488 103/7206 0.0468178367489 ko04670 Leukocyte transendothelial migration 4/488 151/7206 0.0469506513783 ko00514 Other types of O-glycan biosynthesis 5/488 30/7206 0.0487601589647