ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	148/731	423/7206	5.50723402865e-47
ko04724	Glutamatergic synapse	58/731	152/7206	1.50257687266e-20
ko05033	Nicotine addiction	34/731	56/7206	1.94949570295e-20
ko04721	Synaptic vesicle cycle	36/731	80/7206	7.01387322516e-16
ko05032	Morphine addiction	42/731	110/7206	3.38717569754e-15
ko04727	GABAergic synapse	39/731	110/7206	5.56322496002e-13
ko04713	Circadian entrainment	44/731	136/7206	7.11105695794e-13
ko04723	Retrograde endocannabinoid signaling	50/731	175/7206	3.84994309459e-12
ko04726	Serotonergic synapse	43/731	137/7206	4.1600191469e-12
ko04728	Dopaminergic synapse	51/731	185/7206	1.03157287193e-11
ko04725	Cholinergic synapse	46/731	160/7206	2.27737482957e-11
ko04024	cAMP signaling pathway	64/731	279/7206	1.84178367387e-10
ko04911	Insulin secretion	34/731	117/7206	7.23965498418e-09
ko04742	Taste transduction	23/731	61/7206	8.8244831156e-09
ko05031	Amphetamine addiction	29/731	91/7206	9.3898788378e-09
ko04921	Oxytocin signaling pathway	48/731	209/7206	3.5236671232e-08
ko04020	Calcium signaling pathway	56/731	265/7206	6.27640071524e-08
ko05030	Cocaine addiction	23/731	73/7206	4.08210166587e-07
ko04970	Salivary secretion	26/731	95/7206	1.54476393129e-06
ko04966	Collecting duct acid secretion	12/731	26/7206	2.73933290566e-06
ko05322	Systemic lupus erythematosus	1/731	151/7206	3.40734816194e-06
ko04720	Long-term potentiation	26/731	99/7206	3.59706385556e-06
ko03040	Spliceosome	1/731	145/7206	4.79569093946e-06
ko05166	HTLV-I infection	10/731	292/7206	1.73504352838e-05
ko04730	Long-term depression	21/731	78/7206	2.04999216991e-05
ko04060	Cytokine-cytokine receptor interaction	4/731	191/7206	2.52553539494e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	20/731	74/7206	3.02481445737e-05
ko05110	Vibrio cholerae infection	18/731	63/7206	3.33549123627e-05
ko05168	Herpes simplex infection	4/731	182/7206	5.10155649151e-05
ko05162	Measles	1/731	120/7206	8.51329006004e-05
ko04925	Aldosterone synthesis and secretion	24/731	105/7206	0.000111619197373
ko05164	Influenza A	4/731	167/7206	0.0002177180273
ko04261	Adrenergic signaling in cardiomyocytes	38/731	205/7206	0.000222803986951
ko04971	Gastric acid secretion	22/731	98/7206	0.000278724148081
ko04972	Pancreatic secretion	24/731	111/7206	0.000334314256369
ko05203	Viral carcinogenesis	12/731	277/7206	0.000502206513735
ko04514	Cell adhesion molecules (CAMs)	26/731	130/7206	0.000610194579246
ko05205	Proteoglycans in cancer	12/731	271/7206	0.000665502777952
ko04022	cGMP-PKG signaling pathway	38/731	216/7206	0.000782616234319
ko04110	Cell cycle	4/731	145/7206	0.00119743842746
ko05200	Pathways in cancer	30/731	492/7206	0.00145459648817
ko00680	Methane metabolism	10/731	34/7206	0.00147912941275
ko04141	Protein processing in endoplasmic reticulum	7/731	184/7206	0.00187717671546
ko04260	Cardiac muscle contraction	20/731	98/7206	0.00200595915788
ko04510	Focal adhesion	11/731	240/7206	0.00218598730081
ko04070	Phosphatidylinositol signaling system	22/731	112/7206	0.002253225849
ko04120	Ubiquitin mediated proteolysis	4/731	138/7206	0.00240706558194
ko03013	RNA transport	6/731	166/7206	0.00255459617607
ko04540	Gap junction	24/731	128/7206	0.00273044553693
ko04710	Circadian rhythm	11/731	43/7206	0.00299633818145
ko05169	Epstein-Barr virus infection	9/731	206/7206	0.00323080134133
ko04630	Jak-STAT signaling pathway	4/731	132/7206	0.00328159634255
ko04745	Phototransduction - fly	10/731	38/7206	0.00367207184025
ko04072	Phospholipase D signaling pathway	33/731	197/7206	0.00374060067697
ko05224	Breast cancer	7/731	174/7206	0.00474009184303
ko04621	NOD-like receptor signaling pathway	6/731	157/7206	0.00475589215289
ko05120	Epithelial cell signaling in Helicobacter pylori infection	18/731	92/7206	0.00511166254526
ko05231	Choline metabolism in cancer	24/731	134/7206	0.00544078967889
ko04010	MAPK signaling pathway	48/731	321/7206	0.00582311203
ko04924	Renin secretion	17/731	86/7206	0.00617333678243
ko04750	Inflammatory mediator regulation of TRP channels	22/731	122/7206	0.00621235483935
ko04810	Regulation of actin cytoskeleton	14/731	264/7206	0.00658729650311
ko04626	Plant-pathogen interaction	6/731	18/7206	0.00680609480715
ko04550	Signaling pathways regulating pluripotency of stem cells	7/731	165/7206	0.0085162292102
ko04151	PI3K-Akt signaling pathway	25/731	390/7206	0.00964545938864
ko05202	Transcriptional misregulation in cancer	9/731	188/7206	0.00997193959764
ko05206	MicroRNAs in cancer	8/731	177/7206	0.0109518166343
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	15/731	79/7206	0.0140722997484
ko04961	Endocrine and other factor-regulated calcium reabsorption	12/731	59/7206	0.0156358637391
ko04330	Notch signaling pathway	1/731	62/7206	0.0185491816227
ko00010	Glycolysis / Gluconeogenesis	14/731	74/7206	0.0187390624596
ko05323	Rheumatoid arthritis	16/731	89/7206	0.0204192856314
ko04612	Antigen processing and presentation	2/731	77/7206	0.0216381417946
ko04610	Complement and coagulation cascades	2/731	79/7206	0.022254714775
ko03008	Ribosome biogenesis in eukaryotes	2/731	79/7206	0.022254714775
ko04964	Proximal tubule bicarbonate reclamation	7/731	29/7206	0.0229616034826
ko03015	mRNA surveillance pathway	3/731	93/7206	0.023083410823
ko00190	Oxidative phosphorylation	21/731	127/7206	0.0246188079771
ko04530	Tight junction	13/731	228/7206	0.0249646752175
ko04390	Hippo signaling pathway	10/731	188/7206	0.0266281778929
ko01230	Biosynthesis of amino acids	15/731	85/7206	0.0288361376449
ko04214	Apoptosis - fly	2/731	72/7206	0.0306605130909
ko04960	Aldosterone-regulated sodium reabsorption	9/731	41/7206	0.0317300768856
ko05133	Pertussis	3/731	87/7206	0.0317464033609
ko04111	Cell cycle - yeast	3/731	90/7206	0.0326201407751
ko04145	Phagosome	25/731	162/7206	0.0338640085586
ko00030	Pentose phosphate pathway	7/731	32/7206	0.0379960050942
ko00280	Valine, leucine and isoleucine degradation	1/731	54/7206	0.0395424184244
ko00520	Amino sugar and nucleotide sugar metabolism	1/731	55/7206	0.0401333723733
ko05217	Basal cell carcinoma	2/731	68/7206	0.0433408696434
ko04218	Cellular senescence	10/731	177/7206	0.0434135663189
ko04217	Necroptosis	10/731	178/7206	0.0435115310831
ko05220	Chronic myeloid leukemia	3/731	85/7206	0.0444877232176
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/731	14/7206	0.0460078929148