ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 46/362 145/7206 1.98402080726e-25 ko04110 Cell cycle 40/362 145/7206 1.04728252162e-19 ko03440 Homologous recombination 22/362 41/7206 1.44417152843e-18 ko04111 Cell cycle - yeast 30/362 90/7206 1.41752104284e-17 ko03460 Fanconi anemia pathway 21/362 51/7206 8.54028744269e-15 ko03022 Basal transcription factors 18/362 44/7206 8.50464733899e-13 ko04113 Meiosis - yeast 21/362 70/7206 1.19080111398e-11 ko03420 Nucleotide excision repair 16/362 46/7206 2.95250659632e-10 ko03013 RNA transport 30/362 166/7206 5.85106728515e-10 ko03030 DNA replication 13/362 38/7206 1.80737596995e-08 ko03430 Mismatch repair 10/362 22/7206 3.40686309691e-08 ko03410 Base excision repair 11/362 38/7206 1.56074306873e-06 ko04144 Endocytosis 2/362 342/7206 5.46364463138e-06 ko04151 PI3K-Akt signaling pathway 4/362 390/7206 2.19695423005e-05 ko04020 Calcium signaling pathway 1/362 265/7206 2.21236816134e-05 ko05322 Systemic lupus erythematosus 20/362 151/7206 6.05992950382e-05 ko03018 RNA degradation 14/362 84/7206 6.47710666253e-05 ko03008 Ribosome biogenesis in eukaryotes 13/362 79/7206 0.000134836531931 ko05166 HTLV-I infection 30/362 292/7206 0.000165261911823 ko04114 Oocyte meiosis 18/362 139/7206 0.000188685374635 ko04914 Progesterone-mediated oocyte maturation 15/362 104/7206 0.000195139917261 ko03015 mRNA surveillance pathway 14/362 93/7206 0.000200549917998 ko05203 Viral carcinogenesis 28/362 277/7206 0.000357878223175 ko04261 Adrenergic signaling in cardiomyocytes 1/362 205/7206 0.000498895339953 ko04120 Ubiquitin mediated proteolysis 17/362 138/7206 0.000513767519219 ko04024 cAMP signaling pathway 3/362 279/7206 0.000642116628514 ko05205 Proteoglycans in cancer 3/362 271/7206 0.000913051711304 ko04010 MAPK signaling pathway 5/362 321/7206 0.00153973244373 ko04728 Dopaminergic synapse 1/362 185/7206 0.00164312414259 ko04723 Retrograde endocannabinoid signaling 1/362 175/7206 0.00232383514773 ko04371 Apelin signaling pathway 1/362 177/7206 0.00239389503687 ko04921 Oxytocin signaling pathway 2/362 209/7206 0.00317076737565 ko00240 Pyrimidine metabolism 13/362 110/7206 0.00331686804959 ko05012 Parkinson's disease 1/362 155/7206 0.0048204575839 ko04621 NOD-like receptor signaling pathway 1/362 157/7206 0.00484293331652 ko04725 Cholinergic synapse 1/362 160/7206 0.0049843920737 ko04724 Glutamatergic synapse 1/362 152/7206 0.00723537522803 ko04270 Vascular smooth muscle contraction 1/362 154/7206 0.00747091927462 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/362 182/7206 0.00885630305101 ko04141 Protein processing in endoplasmic reticulum 2/362 184/7206 0.00903240293283 ko04022 cGMP-PKG signaling pathway 3/362 216/7206 0.0101409859879 ko04510 Focal adhesion 4/362 240/7206 0.0101412991085 ko05418 Fluid shear stress and atherosclerosis 2/362 173/7206 0.0124659918385 ko04810 Regulation of actin cytoskeleton 5/362 264/7206 0.0138434018358 ko04915 Estrogen signaling pathway 1/362 131/7206 0.0147213708648 ko04380 Osteoclast differentiation 1/362 134/7206 0.0148733589863 ko04933 AGE-RAGE signaling pathway in diabetic complications 1/362 135/7206 0.0150033164417 ko04713 Circadian entrainment 1/362 136/7206 0.0151732088144 ko04931 Insulin resistance 1/362 137/7206 0.0153832667247 ko04726 Serotonergic synapse 1/362 137/7206 0.0153832667247 ko04071 Sphingolipid signaling pathway 2/362 162/7206 0.017474180594 ko04072 Phospholipase D signaling pathway 3/362 197/7206 0.019018532037 ko05145 Toxoplasmosis 1/362 126/7206 0.021495056198 ko01200 Carbon metabolism 1/362 128/7206 0.0219154470055 ko04540 Gap junction 1/362 128/7206 0.0219154470055 ko05142 Chagas disease (American trypanosomiasis) 1/362 130/7206 0.0225571212349 ko04514 Cell adhesion molecules (CAMs) 1/362 130/7206 0.0225571212349 ko04015 Rap1 signaling pathway 6/362 278/7206 0.0238803243342 ko04014 Ras signaling pathway 6/362 279/7206 0.024007592927 ko05167 Kaposi's sarcoma-associated herpesvirus infection 3/362 191/7206 0.0267834051726 ko00310 Lysine degradation 8/362 73/7206 0.029208037773 ko04911 Insulin secretion 1/362 117/7206 0.0308223745088 ko04115 p53 signaling pathway 8/362 74/7206 0.0313744084489 ko04750 Inflammatory mediator regulation of TRP channels 1/362 122/7206 0.0324838908801 ko04330 Notch signaling pathway 7/362 62/7206 0.0348261950475 ko04142 Lysosome 2/362 151/7206 0.0353978642225 ko04530 Tight junction 5/362 228/7206 0.0444204743924 ko04727 GABAergic synapse 1/362 110/7206 0.0446237202119 ko05032 Morphine addiction 1/362 110/7206 0.0446237202119 ko04972 Pancreatic secretion 1/362 111/7206 0.04498479715 ko04360 Axon guidance 5/362 233/7206 0.0453033532765 ko04062 Chemokine signaling pathway 4/362 201/7206 0.0474142418174 ko05034 Alcoholism 19/362 238/7206 0.0474391326571