ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 75/492 423/7206 3.25813854322e-15 ko04724 Glutamatergic synapse 36/492 152/7206 1.9279639566e-11 ko05032 Morphine addiction 29/492 110/7206 1.18612681346e-10 ko04713 Circadian entrainment 32/492 136/7206 3.16319684329e-10 ko04024 cAMP signaling pathway 48/492 279/7206 1.40437982461e-09 ko04911 Insulin secretion 28/492 117/7206 2.77613707143e-09 ko04728 Dopaminergic synapse 35/492 185/7206 2.24556379914e-08 ko04727 GABAergic synapse 25/492 110/7206 6.03092267318e-08 ko04725 Cholinergic synapse 31/492 160/7206 8.30259922254e-08 ko05033 Nicotine addiction 17/492 56/7206 9.35960137252e-08 ko04971 Gastric acid secretion 23/492 98/7206 1.0947236572e-07 ko04726 Serotonergic synapse 28/492 137/7206 1.09968165337e-07 ko04020 Calcium signaling pathway 41/492 265/7206 5.95591178111e-07 ko04723 Retrograde endocannabinoid signaling 31/492 175/7206 6.72676665273e-07 ko04070 Phosphatidylinositol signaling system 22/492 112/7206 5.12826172615e-06 ko05031 Amphetamine addiction 19/492 91/7206 8.98200022348e-06 ko04721 Synaptic vesicle cycle 17/492 80/7206 2.0842007819e-05 ko04720 Long-term potentiation 19/492 99/7206 3.17559855045e-05 ko04966 Collecting duct acid secretion 9/492 26/7206 3.27779403858e-05 ko04921 Oxytocin signaling pathway 31/492 209/7206 3.48712923964e-05 ko04972 Pancreatic secretion 19/492 111/7206 0.000160068853379 ko04745 Phototransduction - fly 10/492 38/7206 0.000166342582316 ko04970 Salivary secretion 17/492 95/7206 0.000202254799654 ko05322 Systemic lupus erythematosus 1/492 151/7206 0.000464230684585 ko04022 cGMP-PKG signaling pathway 29/492 216/7206 0.000477621833632 ko04964 Proximal tubule bicarbonate reclamation 8/492 29/7206 0.000531888540879 ko04925 Aldosterone synthesis and secretion 17/492 105/7206 0.000684257788611 ko04730 Long-term depression 14/492 78/7206 0.000703478731166 ko00562 Inositol phosphate metabolism 15/492 89/7206 0.000910880452727 ko04261 Adrenergic signaling in cardiomyocytes 27/492 205/7206 0.00099456830638 ko05030 Cocaine addiction 13/492 73/7206 0.00116713494753 ko05120 Epithelial cell signaling in Helicobacter pylori infection 15/492 92/7206 0.00129405883261 ko04072 Phospholipase D signaling pathway 25/492 197/7206 0.00232128140941 ko05110 Vibrio cholerae infection 11/492 63/7206 0.00322125263635 ko05224 Breast cancer 3/492 174/7206 0.00340917903368 ko05014 Amyotrophic lateral sclerosis (ALS) 12/492 74/7206 0.00402330707117 ko03040 Spliceosome 2/492 145/7206 0.00412872038666 ko04626 Plant-pathogen interaction 5/492 18/7206 0.00591358187404 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/492 59/7206 0.00607304162914 ko00680 Methane metabolism 7/492 34/7206 0.00708148104888 ko04540 Gap junction 17/492 128/7206 0.00712275207137 ko04918 Thyroid hormone synthesis 13/492 86/7206 0.0074300854495 ko04360 Axon guidance 27/492 233/7206 0.00754432959796 ko00230 Purine metabolism 23/492 194/7206 0.00868234589058 ko04744 Phototransduction 7/492 36/7206 0.00976591745366 ko04750 Inflammatory mediator regulation of TRP channels 16/492 122/7206 0.0101773317002 ko04371 Apelin signaling pathway 21/492 177/7206 0.0143649264441 ko05166 HTLV-I infection 10/492 292/7206 0.0171035133928 ko04978 Mineral absorption 7/492 40/7206 0.0172437354296 ko04110 Cell cycle 3/492 145/7206 0.0183340574038 ko03013 RNA transport 4/492 166/7206 0.0184417504493 ko00030 Pentose phosphate pathway 6/492 32/7206 0.0194381253407 ko04960 Aldosterone-regulated sodium reabsorption 7/492 41/7206 0.0196115608557 ko00051 Fructose and mannose metabolism 7/492 42/7206 0.0221975444168 ko04270 Vascular smooth muscle contraction 18/492 154/7206 0.0225451073795 ko05169 Epstein-Barr virus infection 6/492 206/7206 0.0235579032267 ko04120 Ubiquitin mediated proteolysis 3/492 138/7206 0.0251570767759 ko00190 Oxidative phosphorylation 15/492 127/7206 0.0321309006726 ko00010 Glycolysis / Gluconeogenesis 10/492 74/7206 0.0331354628702 ko04922 Glucagon signaling pathway 15/492 128/7206 0.0334375937756 ko04742 Taste transduction 9/492 61/7206 0.0347517108915 ko04014 Ras signaling pathway 28/492 279/7206 0.0385454763572 ko04145 Phagosome 18/492 162/7206 0.0387086390184 ko04062 Chemokine signaling pathway 21/492 201/7206 0.0462130813773 ko04912 GnRH signaling pathway 14/492 122/7206 0.0463246082373 ko04924 Renin secretion 11/492 86/7206 0.0475531590707