ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	207/1188	423/7206	3.25083526176e-58
ko04724	Glutamatergic synapse	93/1188	152/7206	3.22139200986e-36
ko05033	Nicotine addiction	50/1188	56/7206	3.51279535988e-33
ko05032	Morphine addiction	73/1188	110/7206	5.53662062553e-32
ko04713	Circadian entrainment	80/1188	136/7206	1.47177771613e-29
ko04727	GABAergic synapse	70/1188	110/7206	5.42005142725e-29
ko04728	Dopaminergic synapse	89/1188	185/7206	3.50141212455e-24
ko04725	Cholinergic synapse	79/1188	160/7206	1.77656555567e-22
ko04721	Synaptic vesicle cycle	52/1188	80/7206	1.90983748597e-22
ko04024	cAMP signaling pathway	112/1188	279/7206	5.55677287796e-22
ko04723	Retrograde endocannabinoid signaling	81/1188	175/7206	9.62251065811e-21
ko04020	Calcium signaling pathway	104/1188	265/7206	1.63285951576e-19
ko04911	Insulin secretion	61/1188	117/7206	4.01848146592e-19
ko04921	Oxytocin signaling pathway	83/1188	209/7206	3.49628524527e-16
ko04744	Phototransduction	28/1188	36/7206	7.15574497279e-16
ko04726	Serotonergic synapse	62/1188	137/7206	1.48367067561e-15
ko04742	Taste transduction	36/1188	61/7206	5.25708176594e-14
ko04720	Long-term potentiation	48/1188	99/7206	9.90060069316e-14
ko05031	Amphetamine addiction	45/1188	91/7206	2.40780726171e-13
ko04261	Adrenergic signaling in cardiomyocytes	75/1188	205/7206	2.02531054159e-12
ko04970	Salivary secretion	44/1188	95/7206	7.84874332171e-12
ko04740	Olfactory transduction	38/1188	80/7206	8.34794495008e-11
ko03040	Spliceosome	1/1188	145/7206	1.93775095735e-10
ko04925	Aldosterone synthesis and secretion	43/1188	105/7206	1.71700634827e-09
ko04971	Gastric acid secretion	40/1188	98/7206	7.14273526482e-09
ko05030	Cocaine addiction	32/1188	73/7206	3.01639747239e-08
ko04060	Cytokine-cytokine receptor interaction	7/1188	191/7206	3.06257211315e-08
ko04022	cGMP-PKG signaling pathway	67/1188	216/7206	7.02877514934e-08
ko04360	Axon guidance	71/1188	233/7206	7.2200785294e-08
ko05203	Viral carcinogenesis	16/1188	277/7206	8.28382621177e-08
ko04070	Phosphatidylinositol signaling system	41/1188	112/7206	2.11684760553e-07
ko04141	Protein processing in endoplasmic reticulum	8/1188	184/7206	5.05784792913e-07
ko05322	Systemic lupus erythematosus	5/1188	151/7206	5.93050275804e-07
ko03013	RNA transport	7/1188	166/7206	1.27206663899e-06
ko05168	Herpes simplex infection	9/1188	182/7206	2.34329945323e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1188	74/7206	3.78921887665e-06
ko04972	Pancreatic secretion	38/1188	111/7206	3.82995137211e-06
ko04540	Gap junction	42/1188	128/7206	5.22823037345e-06
ko04010	MAPK signaling pathway	84/1188	321/7206	6.79692152478e-06
ko04514	Cell adhesion molecules (CAMs)	42/1188	130/7206	6.84377795867e-06
ko04730	Long-term depression	29/1188	78/7206	8.56219406705e-06
ko04745	Phototransduction - fly	18/1188	38/7206	8.69130836071e-06
ko04072	Phospholipase D signaling pathway	57/1188	197/7206	9.12186499699e-06
ko04924	Renin secretion	31/1188	86/7206	1.11401123072e-05
ko04966	Collecting duct acid secretion	14/1188	26/7206	1.37724930037e-05
ko04621	NOD-like receptor signaling pathway	8/1188	157/7206	1.74551118706e-05
ko05164	Influenza A	9/1188	167/7206	1.87580864847e-05
ko04110	Cell cycle	7/1188	145/7206	2.26404686154e-05
ko04612	Antigen processing and presentation	1/1188	77/7206	3.24689115994e-05
ko05110	Vibrio cholerae infection	24/1188	63/7206	4.06456946976e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1188	79/7206	4.15596020251e-05
ko05414	Dilated cardiomyopathy	36/1188	112/7206	4.73057485919e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1188	122/7206	5.9212293077e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1188	59/7206	0.000114785647309
ko05162	Measles	6/1188	120/7206	0.000169970940774
ko04260	Cardiac muscle contraction	31/1188	98/7206	0.000171898199044
ko04610	Complement and coagulation cascades	2/1188	79/7206	0.000173994763607
ko03008	Ribosome biogenesis in eukaryotes	2/1188	79/7206	0.000173994763607
ko04014	Ras signaling pathway	70/1188	279/7206	0.000192868995755
ko05169	Epstein-Barr virus infection	16/1188	206/7206	0.000272164660702
ko04371	Apelin signaling pathway	48/1188	177/7206	0.000291666706428
ko04915	Estrogen signaling pathway	38/1188	131/7206	0.000301842392275
ko04976	Bile secretion	26/1188	80/7206	0.000374141382714
ko05205	Proteoglycans in cancer	25/1188	271/7206	0.00059349907324
ko04120	Ubiquitin mediated proteolysis	9/1188	138/7206	0.000695343206306
ko04912	GnRH signaling pathway	35/1188	122/7206	0.000753343679582
ko04626	Plant-pathogen interaction	9/1188	18/7206	0.00102592168694
ko04064	NF-kappa B signaling pathway	5/1188	96/7206	0.00127244866897
ko05140	Leishmaniasis	3/1188	75/7206	0.0014891137209
ko00590	Arachidonic acid metabolism	1/1188	52/7206	0.00203099041016
ko00240	Pyrimidine metabolism	7/1188	110/7206	0.00259466029323
ko04710	Circadian rhythm	15/1188	43/7206	0.00298101806715
ko04923	Regulation of lipolysis in adipocytes	23/1188	77/7206	0.00298762153622
ko04146	Peroxisome	5/1188	89/7206	0.00359023252777
ko04922	Glucagon signaling pathway	34/1188	128/7206	0.00360943067192
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1188	14/7206	0.00381934945205
ko04015	Rap1 signaling pathway	64/1188	278/7206	0.00383170736621
ko05144	Malaria	1/1188	45/7206	0.00439707019429
ko00071	Fatty acid degradation	1/1188	45/7206	0.00439707019429
ko03420	Nucleotide excision repair	1/1188	46/7206	0.00441011895954
ko04350	TGF-beta signaling pathway	7/1188	103/7206	0.00480890008131
ko04657	IL-17 signaling pathway	5/1188	87/7206	0.00511218824905
ko00480	Glutathione metabolism	2/1188	55/7206	0.00564523883622
ko05321	Inflammatory bowel disease (IBD)	2/1188	56/7206	0.00574811572708
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1188	100/7206	0.00648342053785
ko03022	Basal transcription factors	1/1188	44/7206	0.00673048322619
ko00310	Lysine degradation	4/1188	73/7206	0.00679943685883
ko04918	Thyroid hormone synthesis	24/1188	86/7206	0.00770769554371
ko05166	HTLV-I infection	32/1188	292/7206	0.00782145877776
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1188	182/7206	0.00814705227394
ko04630	Jak-STAT signaling pathway	11/1188	132/7206	0.00884412127015
ko05161	Hepatitis B	16/1188	173/7206	0.00910136476981
ko05231	Choline metabolism in cancer	34/1188	134/7206	0.00916187164946
ko04622	RIG-I-like receptor signaling pathway	3/1188	62/7206	0.00918818895924
ko04214	Apoptosis - fly	4/1188	72/7206	0.0097011216007
ko04217	Necroptosis	17/1188	178/7206	0.0102394536092
ko04658	Th1 and Th2 cell differentiation	7/1188	96/7206	0.0120965798228
ko00562	Inositol phosphate metabolism	24/1188	89/7206	0.0134694104687
ko00330	Arginine and proline metabolism	3/1188	61/7206	0.0136880836674
ko00630	Glyoxylate and dicarboxylate metabolism	1/1188	38/7206	0.0147866813615
ko03410	Base excision repair	1/1188	38/7206	0.0147866813615
ko04114	Oocyte meiosis	34/1188	139/7206	0.0148188096571
ko05145	Toxoplasmosis	11/1188	126/7206	0.0151713850843
ko04062	Chemokine signaling pathway	46/1188	201/7206	0.0158495503237
ko05418	Fluid shear stress and atherosclerosis	17/1188	173/7206	0.016573611743
ko03018	RNA degradation	6/1188	84/7206	0.017352619915
ko00260	Glycine, serine and threonine metabolism	2/1188	48/7206	0.017622682713
ko01524	Platinum drug resistance	5/1188	76/7206	0.0185018142322
ko04210	Apoptosis	18/1188	180/7206	0.0187277380566
ko04973	Carbohydrate digestion and absorption	13/1188	42/7206	0.0193466989565
ko04964	Proximal tubule bicarbonate reclamation	10/1188	29/7206	0.0194390746101
ko05214	Glioma	21/1188	79/7206	0.0212153285552
ko04916	Melanogenesis	34/1188	142/7206	0.0216337103614
ko05131	Shigellosis	6/1188	82/7206	0.0236771696789
ko04115	p53 signaling pathway	5/1188	74/7206	0.0258024360128
ko00280	Valine, leucine and isoleucine degradation	3/1188	54/7206	0.0263230013993
ko05133	Pertussis	7/1188	87/7206	0.0292197501966
ko05016	Huntington's disease	24/1188	215/7206	0.0317168370517
ko04550	Signaling pathways regulating pluripotency of stem cells	17/1188	165/7206	0.0330504931519
ko00860	Porphyrin and chlorophyll metabolism	1/1188	34/7206	0.0337090544297
ko03320	PPAR signaling pathway	5/1188	69/7206	0.0340921429947
ko04960	Aldosterone-regulated sodium reabsorption	12/1188	41/7206	0.0343581359202
ko04330	Notch signaling pathway	4/1188	62/7206	0.036957531224
ko05215	Prostate cancer	10/1188	111/7206	0.0378933023687
ko00230	Purine metabolism	43/1188	194/7206	0.0387646650989
ko04930	Type II diabetes mellitus	15/1188	54/7206	0.0400303192185
ko05034	Alcoholism	51/1188	238/7206	0.0408797407176
ko04620	Toll-like receptor signaling pathway	9/1188	100/7206	0.0414718817576
ko04510	Focal adhesion	28/1188	240/7206	0.0416007075394
ko00512	Mucin type O-glycan biosynthesis	9/1188	29/7206	0.0438448352375
ko05217	Basal cell carcinoma	5/1188	68/7206	0.046908233984
ko04270	Vascular smooth muscle contraction	35/1188	154/7206	0.0471933404177
ko04659	Th17 cell differentiation	10/1188	106/7206	0.0479125698543
ko04711	Circadian rhythm - fly	5/1188	13/7206	0.0489405636892