ko pathway ratio_in_study ratio_in_pop p_value ko04146 Peroxisome 22/505 89/7206 1.22294805025e-07 ko00350 Tyrosine metabolism 13/505 33/7206 1.31661552583e-07 ko00380 Tryptophan metabolism 16/505 50/7206 1.41297961812e-07 ko04976 Bile secretion 20/505 80/7206 3.77977209357e-07 ko05166 HTLV-I infection 3/505 292/7206 1.69740719758e-06 ko04974 Protein digestion and absorption 21/505 96/7206 2.08235561674e-06 ko00983 Drug metabolism - other enzymes 13/505 42/7206 3.25968076946e-06 ko00360 Phenylalanine metabolism 8/505 17/7206 7.60693058766e-06 ko02010 ABC transporters 12/505 39/7206 8.37721768081e-06 ko04144 Endocytosis 6/505 342/7206 1.05111298019e-05 ko04975 Fat digestion and absorption 11/505 35/7206 1.5962553211e-05 ko00950 Isoquinoline alkaloid biosynthesis 6/505 10/7206 1.89482429532e-05 ko00830 Retinol metabolism 12/505 42/7206 1.9506539055e-05 ko01200 Carbon metabolism 23/505 128/7206 2.26030729451e-05 ko00643 Styrene degradation 4/505 4/7206 2.38549359544e-05 ko00982 Drug metabolism - cytochrome P450 11/505 37/7206 2.87607124309e-05 ko04390 Hippo signaling pathway 1/505 188/7206 3.0709664421e-05 ko00120 Primary bile acid biosynthesis 8/505 20/7206 3.26433065425e-05 ko00590 Arachidonic acid metabolism 13/505 52/7206 4.23448468542e-05 ko05200 Pathways in cancer 14/505 492/7206 4.89968068998e-05 ko00591 Linoleic acid metabolism 8/505 22/7206 7.30935707879e-05 ko00140 Steroid hormone biosynthesis 11/505 41/7206 8.21917858008e-05 ko05204 Chemical carcinogenesis 12/505 48/7206 8.34028224236e-05 ko00260 Glycine, serine and threonine metabolism 12/505 48/7206 8.34028224236e-05 ko04710 Circadian rhythm 11/505 43/7206 0.000131615967243 ko00592 alpha-Linolenic acid metabolism 7/505 19/7206 0.000190972822038 ko00071 Fatty acid degradation 11/505 45/7206 0.00020432131433 ko00362 Benzoate degradation 4/505 6/7206 0.000319149591576 ko01230 Biosynthesis of amino acids 15/505 85/7206 0.000726019810503 ko03320 PPAR signaling pathway 13/505 69/7206 0.000858498730822 ko04614 Renin-angiotensin system 6/505 18/7206 0.00103111622412 ko04610 Complement and coagulation cascades 14/505 79/7206 0.00103658946777 ko00620 Pyruvate metabolism 10/505 46/7206 0.0010702269707 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/505 4/7206 0.0012975754605 ko00290 Valine, leucine and isoleucine biosynthesis 3/505 4/7206 0.0012975754605 ko03010 Ribosome 1/505 129/7206 0.00144673029603 ko00980 Metabolism of xenobiotics by cytochrome P450 9/505 40/7206 0.00146016481446 ko05169 Epstein-Barr virus infection 4/505 206/7206 0.00197668597706 ko04972 Pancreatic secretion 17/505 111/7206 0.00202048918262 ko04151 PI3K-Akt signaling pathway 13/505 390/7206 0.00208778913695 ko05224 Breast cancer 3/505 174/7206 0.00239103538225 ko05162 Measles 1/505 120/7206 0.00317532954733 ko04977 Vitamin digestion and absorption 6/505 22/7206 0.00325827279375 ko05167 Kaposi's sarcoma-associated herpesvirus infection 4/505 191/7206 0.00369991417799 ko05203 Viral carcinogenesis 8/505 277/7206 0.00372946569236 ko04360 Axon guidance 6/505 233/7206 0.00389216551305 ko04550 Signaling pathways regulating pluripotency of stem cells 3/505 165/7206 0.00482552122028 ko03013 RNA transport 3/505 166/7206 0.00489536040211 ko05202 Transcriptional misregulation in cancer 4/505 188/7206 0.00527601444989 ko04978 Mineral absorption 8/505 40/7206 0.0057424991767 ko04750 Inflammatory mediator regulation of TRP channels 17/505 122/7206 0.00610878480467 ko04310 Wnt signaling pathway 4/505 181/7206 0.00718790660568 ko00640 Propanoate metabolism 7/505 34/7206 0.00814299519816 ko00680 Methane metabolism 7/505 34/7206 0.00814299519816 ko01212 Fatty acid metabolism 10/505 60/7206 0.00819646157117 ko05322 Systemic lupus erythematosus 3/505 151/7206 0.00928936619634 ko00710 Carbon fixation in photosynthetic organisms 6/505 27/7206 0.00958961935856 ko04726 Serotonergic synapse 18/505 137/7206 0.0098193176373 ko04350 TGF-beta signaling pathway 1/505 103/7206 0.00986551692305 ko04744 Phototransduction 7/505 36/7206 0.0111947904996 ko00561 Glycerolipid metabolism 10/505 63/7206 0.0115170039115 ko04666 Fc gamma R-mediated phagocytosis 2/505 122/7206 0.0117807419954 ko04660 T cell receptor signaling pathway 2/505 124/7206 0.0118585698424 ko04922 Glucagon signaling pathway 17/505 128/7206 0.0126406766269 ko00100 Steroid biosynthesis 5/505 21/7206 0.0131800317086 ko05164 Influenza A 4/505 167/7206 0.0133789381251 ko04020 Calcium signaling pathway 29/505 265/7206 0.0140560580801 ko04658 Th1 and Th2 cell differentiation 1/505 96/7206 0.0140994091304 ko00230 Purine metabolism 23/505 194/7206 0.01414556534 ko00250 Alanine, aspartate and glutamate metabolism 7/505 38/7206 0.0149995910721 ko00270 Cysteine and methionine metabolism 8/505 47/7206 0.0152821984436 ko00053 Ascorbate and aldarate metabolism 5/505 22/7206 0.0160981960955 ko00010 Glycolysis / Gluconeogenesis 11/505 74/7206 0.0178398102806 ko04150 mTOR signaling pathway 5/505 184/7206 0.0181387705852 ko00564 Glycerophospholipid metabolism 13/505 99/7206 0.0263073642052 ko00965 Betalain biosynthesis 2/505 4/7206 0.0267466634759 ko00340 Histidine metabolism 5/505 25/7206 0.0273266609099 ko01040 Biosynthesis of unsaturated fatty acids 5/505 25/7206 0.0273266609099 ko00920 Sulfur metabolism 3/505 10/7206 0.0283265731067 ko00040 Pentose and glucuronate interconversions 5/505 26/7206 0.0319482300182 ko00410 beta-Alanine metabolism 6/505 35/7206 0.0327799658986 ko00500 Starch and sucrose metabolism 6/505 35/7206 0.0327799658986 ko00330 Arginine and proline metabolism 9/505 61/7206 0.0367911921405 ko04742 Taste transduction 9/505 61/7206 0.0367911921405 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/505 11/7206 0.0369659720469 ko04141 Protein processing in endoplasmic reticulum 6/505 184/7206 0.0402227784204 ko04664 Fc epsilon RI signaling pathway 1/505 77/7206 0.0424362838716 ko00232 Caffeine metabolism 2/505 5/7206 0.0425277835922 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/505 5/7206 0.0425277835922 ko05100 Bacterial invasion of epithelial cells 2/505 99/7206 0.0465306593348 ko04620 Toll-like receptor signaling pathway 2/505 100/7206 0.0466912696203 ko00630 Glyoxylate and dicarboxylate metabolism 6/505 38/7206 0.046779270728 ko04520 Adherens junction 2/505 103/7206 0.0481652982977 ko04964 Proximal tubule bicarbonate reclamation 5/505 29/7206 0.0486032370684