ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 25/234 152/7206 1.26668739655e-11 ko04070 Phosphatidylinositol signaling system 19/234 112/7206 2.41526018203e-09 ko04723 Retrograde endocannabinoid signaling 23/234 175/7206 8.30974583613e-09 ko04727 GABAergic synapse 18/234 110/7206 1.17187190883e-08 ko04020 Calcium signaling pathway 28/234 265/7206 2.59419656009e-08 ko05231 Choline metabolism in cancer 19/234 134/7206 5.09677350252e-08 ko05032 Morphine addiction 17/234 110/7206 7.28217001417e-08 ko04720 Long-term potentiation 16/234 99/7206 9.38935473544e-08 ko04713 Circadian entrainment 18/234 136/7206 3.37343650531e-07 ko04072 Phospholipase D signaling pathway 22/234 197/7206 3.42075312157e-07 ko05033 Nicotine addiction 11/234 56/7206 1.37140278268e-06 ko04080 Neuroactive ligand-receptor interaction 33/234 423/7206 2.50429801529e-06 ko04911 Insulin secretion 15/234 117/7206 4.96935730496e-06 ko04728 Dopaminergic synapse 19/234 185/7206 7.8053560057e-06 ko04726 Serotonergic synapse 16/234 137/7206 8.17374702165e-06 ko04012 ErbB signaling pathway 14/234 109/7206 1.01281268317e-05 ko04024 cAMP signaling pathway 24/234 279/7206 1.09201688521e-05 ko04725 Cholinergic synapse 17/234 160/7206 1.52243261745e-05 ko00562 Inositol phosphate metabolism 12/234 89/7206 2.68642616602e-05 ko04925 Aldosterone synthesis and secretion 13/234 105/7206 3.14565322883e-05 ko04666 Fc gamma R-mediated phagocytosis 14/234 122/7206 3.71115788446e-05 ko04261 Adrenergic signaling in cardiomyocytes 18/234 205/7206 0.000110697218874 ko04742 Taste transduction 9/234 61/7206 0.000136769288766 ko04730 Long-term depression 10/234 78/7206 0.000194709951979 ko04022 cGMP-PKG signaling pathway 18/234 216/7206 0.000214651412166 ko05214 Glioma 10/234 79/7206 0.000216687992539 ko04062 Chemokine signaling pathway 17/234 201/7206 0.000269935219821 ko04915 Estrogen signaling pathway 13/234 131/7206 0.000309713232593 ko04320 Dorso-ventral axis formation 6/234 31/7206 0.000409272878913 ko04914 Progesterone-mediated oocyte maturation 11/234 104/7206 0.000520602808979 ko04912 GnRH signaling pathway 12/234 122/7206 0.000570400683947 ko01521 EGFR tyrosine kinase inhibitor resistance 11/234 106/7206 0.000612932703253 ko05031 Amphetamine addiction 10/234 91/7206 0.000687864864847 ko04972 Pancreatic secretion 11/234 111/7206 0.000905015528533 ko04010 MAPK signaling pathway 22/234 321/7206 0.000941127788152 ko04970 Salivary secretion 10/234 95/7206 0.000965762015168 ko04921 Oxytocin signaling pathway 16/234 209/7206 0.00120964863221 ko05223 Non-small cell lung cancer 8/234 66/7206 0.00123911413926 ko04015 Rap1 signaling pathway 19/234 278/7206 0.00259584156201 ko04540 Gap junction 11/234 128/7206 0.00287169323668 ko05213 Endometrial cancer 7/234 62/7206 0.00374030459248 ko04270 Vascular smooth muscle contraction 12/234 154/7206 0.00422157456492 ko04740 Olfactory transduction 8/234 80/7206 0.00424055640995 ko04750 Inflammatory mediator regulation of TRP channels 10/234 122/7206 0.00615319569796 ko04071 Sphingolipid signaling pathway 12/234 162/7206 0.00631457170212 ko04924 Renin secretion 8/234 86/7206 0.00657602831832 ko04919 Thyroid hormone signaling pathway 11/234 143/7206 0.00666572292971 ko04011 MAPK signaling pathway - yeast 6/234 53/7206 0.00704576301191 ko04745 Phototransduction - fly 5/234 38/7206 0.00723910250327 ko04371 Apelin signaling pathway 13/234 177/7206 0.00758172786712 ko04930 Type II diabetes mellitus 6/234 54/7206 0.00771683219649 ko05030 Cocaine addiction 7/234 73/7206 0.00917902643068 ko05142 Chagas disease (American trypanosomiasis) 10/234 130/7206 0.00950297589247 ko04973 Carbohydrate digestion and absorption 5/234 42/7206 0.0110495195639 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 4/234 28/7206 0.0120213985867 ko04923 Regulation of lipolysis in adipocytes 7/234 77/7206 0.0121522128324 ko00512 Mucin type O-glycan biosynthesis 4/234 29/7206 0.0135975888423 ko04014 Ras signaling pathway 17/234 279/7206 0.0139336186605 ko04971 Gastric acid secretion 8/234 98/7206 0.0140161877689 ko00564 Glycerophospholipid metabolism 8/234 99/7206 0.014835513267 ko05146 Amoebiasis 8/234 99/7206 0.014835513267 ko05230 Central carbon metabolism in cancer 7/234 81/7206 0.0157653524214 ko05143 African trypanosomiasis 4/234 32/7206 0.0190908362054 ko04722 Neurotrophin signaling pathway 11/234 160/7206 0.019612089423 ko05218 Melanoma 7/234 85/7206 0.0200834454482 ko05210 Colorectal cancer 7/234 86/7206 0.0212803051939 ko04916 Melanogenesis 10/234 142/7206 0.0257227847915 ko04744 Phototransduction 4/234 36/7206 0.0282907224418 ko04139 Mitophagy - yeast 4/234 37/7206 0.0309376474829 ko04141 Protein processing in endoplasmic reticulum 1/234 184/7206 0.0320275692195 ko05211 Renal cell carcinoma 7/234 96/7206 0.0360631381076 ko05203 Viral carcinogenesis 3/234 277/7206 0.0361842084951 ko04370 VEGF signaling pathway 6/234 77/7206 0.0384383026891 ko04960 Aldosterone-regulated sodium reabsorption 4/234 41/7206 0.042942542713 ko04611 Platelet activation 10/234 163/7206 0.0434846965216 ko00515 Mannose type O-glycan biosynthesis 3/234 25/7206 0.0459428727368