ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 33/484 191/7206 3.63077906114e-07 ko04610 Complement and coagulation cascades 18/484 79/7206 3.33841016764e-06 ko00120 Primary bile acid biosynthesis 8/484 20/7206 2.39562144235e-05 ko05150 Staphylococcus aureus infection 10/484 36/7206 8.8204975559e-05 ko04710 Circadian rhythm 11/484 43/7206 8.98124330863e-05 ko03013 RNA transport 1/484 166/7206 0.000217287309036 ko00350 Tyrosine metabolism 9/484 33/7206 0.000232395398334 ko04380 Osteoclast differentiation 21/484 134/7206 0.00029393757279 ko04621 NOD-like receptor signaling pathway 23/484 157/7206 0.000501106611173 ko04630 Jak-STAT signaling pathway 20/484 132/7206 0.000564261485093 ko03320 PPAR signaling pathway 13/484 69/7206 0.000575147810257 ko02010 ABC transporters 9/484 39/7206 0.000889662741005 ko05321 Inflammatory bowel disease (IBD) 11/484 56/7206 0.00104978033017 ko03040 Spliceosome 1/484 145/7206 0.00107304295008 ko04110 Cell cycle 1/484 145/7206 0.00107304295008 ko00592 alpha-Linolenic acid metabolism 6/484 19/7206 0.00113616055336 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/484 4/7206 0.00114467737356 ko00140 Steroid hormone biosynthesis 9/484 41/7206 0.00130436439758 ko05034 Alcoholism 5/484 238/7206 0.00213245439773 ko03010 Ribosome 1/484 129/7206 0.00214706147299 ko04146 Peroxisome 14/484 89/7206 0.00225760090672 ko00950 Isoquinoline alkaloid biosynthesis 4/484 10/7206 0.00304680806587 ko05340 Primary immunodeficiency 7/484 30/7206 0.00309646166679 ko00360 Phenylalanine metabolism 5/484 17/7206 0.00421157184717 ko05224 Breast cancer 3/484 174/7206 0.00500886101577 ko04064 NF-kappa B signaling pathway 14/484 96/7206 0.00580591857057 ko00590 Arachidonic acid metabolism 9/484 52/7206 0.00710041915075 ko04390 Hippo signaling pathway 4/484 188/7206 0.00718986949605 ko00500 Starch and sucrose metabolism 7/484 35/7206 0.00764588318657 ko04270 Vascular smooth muscle contraction 19/484 154/7206 0.0086009525028 ko04611 Platelet activation 20/484 163/7206 0.0100305392361 ko00982 Drug metabolism - cytochrome P450 7/484 37/7206 0.0104252626861 ko04022 cGMP-PKG signaling pathway 24/484 216/7206 0.0126755952499 ko04658 Th1 and Th2 cell differentiation 13/484 96/7206 0.0126826693589 ko04650 Natural killer cell mediated cytotoxicity 13/484 97/7206 0.0135943515019 ko05168 Herpes simplex infection 21/484 182/7206 0.0150645394487 ko05162 Measles 15/484 120/7206 0.0162436380982 ko03015 mRNA surveillance pathway 1/484 93/7206 0.0204630263523 ko00983 Drug metabolism - other enzymes 7/484 42/7206 0.0204747519672 ko00051 Fructose and mannose metabolism 7/484 42/7206 0.0204747519672 ko00052 Galactose metabolism 6/484 33/7206 0.0208601129268 ko00643 Styrene degradation 2/484 4/7206 0.0246659483082 ko05164 Influenza A 19/484 167/7206 0.0265016480811 ko05145 Toxoplasmosis 15/484 126/7206 0.0288120604543 ko00071 Fatty acid degradation 7/484 45/7206 0.0289957011054 ko04659 Th17 cell differentiation 13/484 106/7206 0.0298747884466 ko04072 Phospholipase D signaling pathway 21/484 197/7206 0.030220559138 ko04111 Cell cycle - yeast 1/484 90/7206 0.030571067261 ko04922 Glucagon signaling pathway 15/484 128/7206 0.0308996707895 ko05160 Hepatitis C 17/484 153/7206 0.0338007300232 ko04622 RIG-I-like receptor signaling pathway 9/484 62/7206 0.0348361384284 ko04672 Intestinal immune network for IgA production 6/484 37/7206 0.0349626707875 ko04640 Hematopoietic cell lineage 9/484 64/7206 0.0375943581503 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/484 5/7206 0.0392973415036 ko04668 TNF signaling pathway 14/484 120/7206 0.0403463662632 ko00564 Glycerophospholipid metabolism 12/484 99/7206 0.0407167489831 ko04068 FoxO signaling pathway 18/484 167/7206 0.0411164706199 ko04620 Toll-like receptor signaling pathway 12/484 100/7206 0.0425318403874 ko04721 Synaptic vesicle cycle 1/484 80/7206 0.0426989261959 ko04914 Progesterone-mediated oocyte maturation 2/484 104/7206 0.0468950563178