ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	181/1059	423/7206	9.30674781775e-48
ko04724	Glutamatergic synapse	85/1059	152/7206	6.10676374316e-33
ko05033	Nicotine addiction	45/1059	56/7206	4.28963663232e-28
ko04713	Circadian entrainment	72/1059	136/7206	5.02309390139e-26
ko05032	Morphine addiction	63/1059	110/7206	2.01767528471e-25
ko04727	GABAergic synapse	59/1059	110/7206	6.84252886796e-22
ko04728	Dopaminergic synapse	79/1059	185/7206	8.77972735038e-21
ko04725	Cholinergic synapse	70/1059	160/7206	3.08733608905e-19
ko04723	Retrograde endocannabinoid signaling	73/1059	175/7206	1.40573251742e-18
ko04024	cAMP signaling pathway	96/1059	279/7206	3.4478067656e-17
ko04911	Insulin secretion	54/1059	117/7206	2.42218788513e-16
ko04721	Synaptic vesicle cycle	43/1059	80/7206	2.53423716064e-16
ko04020	Calcium signaling pathway	90/1059	265/7206	1.13845210066e-15
ko04921	Oxytocin signaling pathway	76/1059	209/7206	2.65426297606e-15
ko04726	Serotonergic synapse	57/1059	137/7206	1.0742473015e-14
ko04720	Long-term potentiation	43/1059	99/7206	3.73679987939e-12
ko04742	Taste transduction	32/1059	61/7206	4.28809081218e-12
ko05031	Amphetamine addiction	40/1059	91/7206	1.34804564293e-11
ko04261	Adrenergic signaling in cardiomyocytes	67/1059	205/7206	3.89825625284e-11
ko04970	Salivary secretion	39/1059	95/7206	2.98968593247e-10
ko04925	Aldosterone synthesis and secretion	39/1059	105/7206	9.17417785697e-09
ko03040	Spliceosome	2/1059	145/7206	4.12107401161e-08
ko04971	Gastric acid secretion	36/1059	98/7206	4.7715116754e-08
ko04744	Phototransduction	19/1059	36/7206	9.16112837446e-08
ko04740	Olfactory transduction	31/1059	80/7206	9.97145270638e-08
ko04022	cGMP-PKG signaling pathway	60/1059	216/7206	4.21116411649e-07
ko05322	Systemic lupus erythematosus	4/1059	151/7206	1.14521076678e-06
ko04010	MAPK signaling pathway	79/1059	321/7206	1.57327632856e-06
ko04730	Long-term depression	28/1059	78/7206	2.51998064346e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1059	74/7206	2.64862929189e-06
ko04360	Axon guidance	61/1059	233/7206	3.08212371879e-06
ko05168	Herpes simplex infection	7/1059	182/7206	3.39512841048e-06
ko05203	Viral carcinogenesis	16/1059	277/7206	3.52899916277e-06
ko04972	Pancreatic secretion	35/1059	111/7206	5.05523211526e-06
ko05030	Cocaine addiction	26/1059	73/7206	6.76829383533e-06
ko04514	Cell adhesion molecules (CAMs)	39/1059	130/7206	7.21925785772e-06
ko04745	Phototransduction - fly	17/1059	38/7206	8.26091023025e-06
ko03013	RNA transport	7/1059	166/7206	1.89807496495e-05
ko04070	Phosphatidylinositol signaling system	34/1059	112/7206	1.92984030811e-05
ko04072	Phospholipase D signaling pathway	51/1059	197/7206	3.50827150632e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1059	79/7206	3.70275175197e-05
ko04540	Gap junction	37/1059	128/7206	3.78767352273e-05
ko04060	Cytokine-cytokine receptor interaction	10/1059	191/7206	4.44600589416e-05
ko04621	NOD-like receptor signaling pathway	7/1059	157/7206	5.35502968159e-05
ko04260	Cardiac muscle contraction	29/1059	98/7206	0.000134874920533
ko04750	Inflammatory mediator regulation of TRP channels	34/1059	122/7206	0.000142227073191
ko04110	Cell cycle	7/1059	145/7206	0.000208252931024
ko05164	Influenza A	9/1059	167/7206	0.000222394886221
ko04976	Bile secretion	24/1059	80/7206	0.000376723979774
ko04964	Proximal tubule bicarbonate reclamation	12/1059	29/7206	0.000437963491958
ko04924	Renin secretion	25/1059	86/7206	0.000568189817639
ko04120	Ubiquitin mediated proteolysis	7/1059	138/7206	0.000573926953483
ko03008	Ribosome biogenesis in eukaryotes	2/1059	79/7206	0.00062621775197
ko04915	Estrogen signaling pathway	34/1059	131/7206	0.000660396005119
ko04141	Protein processing in endoplasmic reticulum	12/1059	184/7206	0.000697351099796
ko04146	Peroxisome	3/1059	89/7206	0.00079132889509
ko04612	Antigen processing and presentation	2/1059	77/7206	0.000940259456848
ko05169	Epstein-Barr virus infection	15/1059	206/7206	0.00132671394921
ko04930	Type II diabetes mellitus	17/1059	54/7206	0.00151104197928
ko05414	Dilated cardiomyopathy	29/1059	112/7206	0.00173290793926
ko04014	Ras signaling pathway	60/1059	279/7206	0.00181275984811
ko04064	NF-kappa B signaling pathway	4/1059	96/7206	0.00194181231643
ko04626	Plant-pathogen interaction	8/1059	18/7206	0.00234707902959
ko04966	Collecting duct acid secretion	10/1059	26/7206	0.0025340365759
ko04270	Vascular smooth muscle contraction	36/1059	154/7206	0.00375622506761
ko05162	Measles	7/1059	120/7206	0.00386959143476
ko04912	GnRH signaling pathway	30/1059	122/7206	0.00409864697557
ko05231	Choline metabolism in cancer	32/1059	134/7206	0.00430340409568
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1059	59/7206	0.00472775848432
ko04371	Apelin signaling pathway	40/1059	177/7206	0.00486890801211
ko04960	Aldosterone-regulated sodium reabsorption	13/1059	41/7206	0.00590840712091
ko04973	Carbohydrate digestion and absorption	13/1059	42/7206	0.00684345999937
ko04710	Circadian rhythm	13/1059	43/7206	0.00803493436781
ko04630	Jak-STAT signaling pathway	9/1059	132/7206	0.00860062465571
ko04610	Complement and coagulation cascades	4/1059	79/7206	0.0102895474416
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1059	14/7206	0.0103616185142
ko05144	Malaria	1/1059	45/7206	0.0106381851229
ko00071	Fatty acid degradation	1/1059	45/7206	0.0106381851229
ko03420	Nucleotide excision repair	1/1059	46/7206	0.0107227298356
ko05110	Vibrio cholerae infection	17/1059	63/7206	0.0108855580837
ko05166	HTLV-I infection	28/1059	292/7206	0.0111160389101
ko04916	Melanogenesis	32/1059	142/7206	0.0114374982085
ko05161	Hepatitis B	14/1059	173/7206	0.0119570144135
ko04015	Rap1 signaling pathway	56/1059	278/7206	0.0119675974613
ko05321	Inflammatory bowel disease (IBD)	2/1059	56/7206	0.0129104360992
ko04217	Necroptosis	15/1059	178/7206	0.0136531061713
ko05205	Proteoglycans in cancer	26/1059	271/7206	0.0141482461931
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1059	100/7206	0.0145102679359
ko03022	Basal transcription factors	1/1059	44/7206	0.0163539845062
ko00280	Valine, leucine and isoleucine degradation	2/1059	54/7206	0.0188689444712
ko00310	Lysine degradation	4/1059	73/7206	0.019934497889
ko04115	p53 signaling pathway	4/1059	74/7206	0.0199505228634
ko05140	Leishmaniasis	4/1059	75/7206	0.0202571005101
ko04923	Regulation of lipolysis in adipocytes	19/1059	77/7206	0.0217537145393
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1059	40/7206	0.023517329036
ko05214	Glioma	19/1059	79/7206	0.0244604112469
ko00590	Arachidonic acid metabolism	2/1059	52/7206	0.0278606227601
ko00330	Arginine and proline metabolism	3/1059	61/7206	0.0279638975506
ko04330	Notch signaling pathway	3/1059	62/7206	0.0285066328564
ko04622	RIG-I-like receptor signaling pathway	3/1059	62/7206	0.0285066328564
ko00240	Pyrimidine metabolism	8/1059	110/7206	0.0286805150985
ko04918	Thyroid hormone synthesis	20/1059	86/7206	0.0310668969915
ko04922	Glucagon signaling pathway	28/1059	128/7206	0.0310770215798
ko04711	Circadian rhythm - fly	5/1059	13/7206	0.0314063835349
ko05222	Small cell lung cancer	6/1059	89/7206	0.0336816578547
ko00982	Drug metabolism - cytochrome P450	1/1059	37/7206	0.0347730247143
ko03410	Base excision repair	1/1059	38/7206	0.0354268127844
ko04142	Lysosome	13/1059	151/7206	0.035627638216
ko05230	Central carbon metabolism in cancer	19/1059	81/7206	0.0381563941362
ko03320	PPAR signaling pathway	4/1059	69/7206	0.0384287808934
ko00260	Glycine, serine and threonine metabolism	2/1059	48/7206	0.0387373334134
ko00230	Purine metabolism	39/1059	194/7206	0.0390809989865
ko04012	ErbB signaling pathway	24/1059	109/7206	0.0395583848586
ko04210	Apoptosis	17/1059	180/7206	0.042762089791
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1059	182/7206	0.0431224284562
ko04657	IL-17 signaling pathway	6/1059	87/7206	0.0457324590525
ko05202	Transcriptional misregulation in cancer	18/1059	188/7206	0.0468092204382
ko00562	Inositol phosphate metabolism	20/1059	89/7206	0.0485194119658
ko05130	Pathogenic Escherichia coli infection	5/1059	77/7206	0.049878151838