ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 29/359 134/7206 9.58576401951e-12 ko04668 TNF signaling pathway 24/359 120/7206 3.42471095329e-09 ko04060 Cytokine-cytokine receptor interaction 31/359 191/7206 3.78704342458e-09 ko04933 AGE-RAGE signaling pathway in diabetic complications 22/359 135/7206 7.00515603306e-07 ko05161 Hepatitis B 25/359 173/7206 1.25561980153e-06 ko05164 Influenza A 24/359 167/7206 2.27714862442e-06 ko04621 NOD-like receptor signaling pathway 23/359 157/7206 2.6586554667e-06 ko04064 NF-kappa B signaling pathway 16/359 96/7206 1.76609338716e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/359 191/7206 2.37825796863e-05 ko04610 Complement and coagulation cascades 14/359 79/7206 2.91074757712e-05 ko04620 Toll-like receptor signaling pathway 16/359 100/7206 2.99003704867e-05 ko05145 Toxoplasmosis 18/359 126/7206 4.6459432847e-05 ko04510 Focal adhesion 27/359 240/7206 5.85820698259e-05 ko04662 B cell receptor signaling pathway 14/359 88/7206 0.000100005433452 ko04512 ECM-receptor interaction 13/359 79/7206 0.000124012158931 ko05160 Hepatitis C 19/359 153/7206 0.000197215903662 ko05321 Inflammatory bowel disease (IBD) 10/359 56/7206 0.000379086013139 ko04660 T cell receptor signaling pathway 16/359 124/7206 0.000404465443287 ko05323 Rheumatoid arthritis 13/359 89/7206 0.000420682811149 ko05142 Chagas disease (American trypanosomiasis) 16/359 130/7206 0.000688518252103 ko05162 Measles 15/359 120/7206 0.000854471714937 ko04622 RIG-I-like receptor signaling pathway 10/359 62/7206 0.000877229253374 ko04974 Protein digestion and absorption 13/359 96/7206 0.00088114439465 ko04658 Th1 and Th2 cell differentiation 13/359 96/7206 0.00088114439465 ko05140 Leishmaniasis 11/359 75/7206 0.00111460236219 ko05133 Pertussis 12/359 87/7206 0.00117092410516 ko04068 FoxO signaling pathway 18/359 167/7206 0.00175210586505 ko04672 Intestinal immune network for IgA production 7/359 37/7206 0.00202254239932 ko04659 Th17 cell differentiation 13/359 106/7206 0.00221676021121 ko04723 Retrograde endocannabinoid signaling 1/359 175/7206 0.00229401482313 ko04210 Apoptosis 19/359 180/7206 0.00246952917482 ko00120 Primary bile acid biosynthesis 5/359 20/7206 0.00248684123329 ko05168 Herpes simplex infection 19/359 182/7206 0.00259226926474 ko04611 Platelet activation 17/359 163/7206 0.00320902408573 ko05215 Prostate cancer 13/359 111/7206 0.00334364056266 ko04630 Jak-STAT signaling pathway 15/359 132/7206 0.00336447126873 ko05034 Alcoholism 3/359 238/7206 0.00357064190495 ko04623 Cytosolic DNA-sensing pathway 7/359 41/7206 0.00372217741205 ko04657 IL-17 signaling pathway 11/359 87/7206 0.00373920221288 ko05418 Fluid shear stress and atherosclerosis 17/359 173/7206 0.00684244552618 ko05131 Shigellosis 10/359 82/7206 0.00722720971569 ko05012 Parkinson's disease 1/359 155/7206 0.00744000059628 ko04218 Cellular senescence 17/359 177/7206 0.00801325641359 ko05150 Staphylococcus aureus infection 6/359 36/7206 0.00802544266698 ko05132 Salmonella infection 11/359 98/7206 0.00919898442681 ko04066 HIF-1 signaling pathway 13/359 123/7206 0.00976003890513 ko05016 Huntington's disease 3/359 215/7206 0.00987005243075 ko03040 Spliceosome 1/359 145/7206 0.010470067284 ko04917 Prolactin signaling pathway 10/359 87/7206 0.0108574220522 ko00140 Steroid hormone biosynthesis 6/359 41/7206 0.0150448123506 ko05340 Primary immunodeficiency 5/359 30/7206 0.0151969434235 ko05146 Amoebiasis 11/359 99/7206 0.0160306643155 ko03013 RNA transport 2/359 166/7206 0.0175914276947 ko04710 Circadian rhythm 6/359 43/7206 0.0187751784004 ko04217 Necroptosis 16/359 178/7206 0.0212800396507 ko05212 Pancreatic cancer 9/359 83/7206 0.0217031566069 ko05144 Malaria 6/359 45/7206 0.0230924534406 ko04931 Insulin resistance 13/359 137/7206 0.0257550489884 ko05166 HTLV-I infection 23/359 292/7206 0.0270719874281 ko04650 Natural killer cell mediated cytotoxicity 10/359 97/7206 0.0288634725857 ko04810 Regulation of actin cytoskeleton 21/359 264/7206 0.0299659512746 ko05134 Legionellosis 8/359 74/7206 0.0300589196941 ko04151 PI3K-Akt signaling pathway 29/359 390/7206 0.0301903642467 ko05219 Bladder cancer 6/359 48/7206 0.0307426029039 ko01522 Endocrine resistance 12/359 124/7206 0.0330518806394 ko05220 Chronic myeloid leukemia 9/359 85/7206 0.0375931842989 ko05152 Tuberculosis 16/359 187/7206 0.0380445949306 ko04152 AMPK signaling pathway 14/359 161/7206 0.0408378277884 ko05222 Small cell lung cancer 9/359 89/7206 0.0427079601192 ko04972 Pancreatic secretion 1/359 111/7206 0.0446814004521 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/359 92/7206 0.0477711599281 ko04921 Oxytocin signaling pathway 17/359 209/7206 0.0499870463461